Skin-sparing mastectomy

Cunnick, Giles; Mokbel, Kefah

doi:10.1016/j.amjsurg.2004.02.004

Cited by 115 publications

(62 citation statements)

References 34 publications

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“…Commonly accepted surgical treatment in centrally or subareolar located tumors is still mastectomy. A metaanalysis of mostly retrospective and partly prospective studies has shown that SSM with the NAC preservation was an oncologically safe treatment in selected patients [13]. However, in most of these studies, peripheral location of tumor has been accepted as the primary criterion for NAC preservation.…”

Section: Discussionmentioning

confidence: 99%

Prediction of occult nipple-areola complex involvement in breast cancer patients

Gülben¹,

Yıldırım²,

Berberoğlu³

2009

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The aim of this study was to evaluate predictive factors for the nipple-areola complex (NaC) involvement, and to define a subgroup of patients who may benefit from skin-sparing mastectomy with the NaC preservation in breast cancer patients. Univariate and multivariate analyses were carried out in the retrospective data of 397 eligible patients. The NaC involvement was histopathologically proved in 58 (14.6%) of the patients. In the multivariate logistic regression analysis showed that tumor location (central vs peripheral; p<0.0001; hazard ratio [HR], 7.5; 95% confidence interval [CI], 3.4-14.6), number of positive axillary lymph nodes (≥10 vs <10; p<0.005; HR, 2.9; CI, 1.3-6.1), and lymphatic vascular invasion (yes vs no; p<0.0001; HR, 3.5; CI, 1.7-7.1) were the most important prognostic factors. Whereas patients with 2 or 3 risk factors were accepted as high-risk group for the NaC involvement, those with no or 1 risk factor was defined as low-risk group. These groups had a 50.0% NaC involvement rate and a 8.1% NaC involvement rate, respectively (p<0.0001). In conclusion, this study showed that patients with 2 or 3 predictive factors had a high risk of the NaC involvement. These risk factors should be taken into consideration in patient selection for skin-sparing mastectomy with the NaC preservation.

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Section: Discussionmentioning

confidence: 99%

Prediction of occult nipple-areola complex involvement in breast cancer patients

Gülben¹,

Yıldırım²,

Berberoğlu³

2009

neo

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“…[1][2][3] Immediate breast reconstruction with one operation, one hospital stay, and one sick leave is commonly favored by women who are of working age.…”

Section: Introductionmentioning

confidence: 99%

“…Retaining as much skin as possible significantly improves the aesthetic appearance of the reconstructed breast and reduces the number of procedures on the contralateral breast to achieve symmetry such as breast augmentation or reduction mammoplasty. 3 Standard SSM removes the breast, nipple-areola complex (NAC), previous biopsy scars, and the skin overlying superficial breast tumours. The dissection of the lower skin flap should not continue beyond the inframammary fold so that the final shape of the reconstruction will be similar to the original breast 3 (Fig.…”

Section: Introductionmentioning

confidence: 99%