Skin Substitutes and Alternatives

Shores, Jaimie T.; Gabriel, Allen; Gupta, Subhas C.

doi:10.1097/01.asw.0000288215.93430.d2

Cited by 55 publications

(89 citation statements)

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“…If a patient is not considered a candidate for wound or defect reconstruction, creative applications of skin substitute technologies may not only significantly benefit a patient, but also be the only option for wound closure. 2 …”

Section: Characteristics and Clinical Use Of Skin Substitutesmentioning

confidence: 99%

“…10 Various tissues have been engineered but the most developed are skin substitutes and a number of these produces have US/FDA approval and are currently available. 2 The need for skin grafting has been the driving force behind the development of these skin substitutes. 11 The skin is the largest single organ of the human body and although composed of only two specialized tissue layers, it remains a reconstructive challenge in many cases when compromised.…”

Section: Modern Skin Engineeringmentioning

confidence: 99%

“…It should reproduce both components of the skin (epidermis and dermis) and provide no antigenicity that could compromise the graft or host or present difficulties with future applications. 2 Because no single product meets all these criteria, each patient case requires careful evaluation before choosing the appropriate treatment. Although many acute and chronic wounds may benefit from a tailored multidisciplinary approach that utilizes one or more of the products mentioned, each patient should be evaluated for other possible therapies before the use of skin substitutes.…”

Section: Characteristics and Clinical Use Of Skin Substitutesmentioning

confidence: 99%

“…In the 1600s, lizard skin was used in western cultures and this progressed to the use of mammalian skins as well as cadaver skin during the twentieth century, including dog and rabbit skin and the still-used pigskin products. [2][3][4] Facial deformities such as defects after the amputation of the nose were the type of problems that received the most attention. A famed practitioner, Sushruta (circa 600 BC), described operations for reconstruction of the nose without any form of anesthesia.…”

Section: Historical Overviewmentioning

confidence: 99%

“…They are commonly divided into three main categories: 2 (1) Split-thickness skin grafts (STSGs) which contain the epidermis and a variable thickness of the upper layers of dermis, leaving the remaining layers of dermis in place to heal by secondary epithelialization from the wound edges and keratinocytes within the adnexa of the deeper dermis. (2) Full-thickness skin grafts (FTSGs) which contain the epidermis and the entire dermis.…”

Section: Types Of Skin Substitutesmentioning

confidence: 99%

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From Basic Wound Healing to Modern Skin Engineering

Andersson¹,

Nettelblad²,

Kratz

2009

Artificial Organs

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Section: Characteristics and Clinical Use Of Skin Substitutesmentioning

confidence: 99%

Section: Modern Skin Engineeringmentioning

confidence: 99%

Section: Characteristics and Clinical Use Of Skin Substitutesmentioning

confidence: 99%

Section: Historical Overviewmentioning

confidence: 99%

Section: Types Of Skin Substitutesmentioning

confidence: 99%

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From Basic Wound Healing to Modern Skin Engineering

Andersson¹,

Nettelblad²,

Kratz

2009

Artificial Organs

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A View on Polymer-Based Composite Materials for Smart Wound Dressings

Baptista-Silva

Alves

Guimarães

et al. 2021

Advances in Material Research and Technology

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Wound management challenges everyday thousands of health professionals, mainly due to the constant monitoring and difficulties in deciding the correct treatment options. When considering chronic wounds, selecting the ideal dressing defies clinical knowledge, when facing the large amount of different materials, its distinctive properties and the uniqueness of each patient needs. This chapter presents

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The Use of Dermal Substitutes in Burn Surgery: Acute Phase

Arno¹,

Jeschke²

2013

Dermal Replacements in General, Burn, and Plastic Surgery

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Dermal substitutes are increasingly becoming an essential part of the burn care strategy. During the acute phase of burn treatment, dermal substitutes improve functional and cosmetic results long-term and thus increase quality of life. In the chronic wound setting, dermal substitutes are used to reconstruct and improve burn scars and other defects. Despite some successes in the use of dermal substitutes there are more needs and requirements to further improve outcomes and hence further research is required not only to strengthen scientific evidence regarding their effects but also to develop new technology and products. Dermal substitutes also emerge as pivotal research strategies to develop adequate scaffolds for stem cells, tissue engineering and regenerative medicine applications to obtain long-lasting and scarless artificial skin. This review discusses status-quo of dermal substitutes and novel strategies in the use of dermal substitutes with a focus on burn care.

show abstract

Skin Substitutes and Alternatives

Cited by 55 publications

References 0 publications

From Basic Wound Healing to Modern Skin Engineering

From Basic Wound Healing to Modern Skin Engineering

A View on Polymer-Based Composite Materials for Smart Wound Dressings

The Use of Dermal Substitutes in Burn Surgery: Acute Phase

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