Skin Surface Electric Potential Induced by Ion-Flux through Epidermal Cell Layers

Denda, Mitsuhiro; Ashida, Yutaka; Inoué, Kaori; Kumazawa, Noriyuki

doi:10.1006/bbrc.2001.4925

Cited by 45 publications

(56 citation statements)

References 18 publications

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“…Recently, we demonstrated that cation dynamics may play an important role in the homeostasis of skin epidermis which is the outermost part of skin tissue (5). And various environmental and neuroendocrinological factors influence on the ion flux through epidermal keratinocytes (6). No report showed existence of VR1 in the epidermis previously, however, VR1 like response was reported in cultured bronchial epithelial cell (7).…”

mentioning

confidence: 99%

Immunoreactivity of VR1 on Epidermal Keratinocyte of Human Skin

Denda

Fuziwara

Inoué

et al. 2001

Biochemical and Biophysical Research Communications

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155

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mentioning

confidence: 99%

Immunoreactivity of VR1 on Epidermal Keratinocyte of Human Skin

Denda

Fuziwara

Inoué

et al. 2001

Biochemical and Biophysical Research Communications

Self Cite

210

155

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“…32,33 In addition, G protein-coupled receptor of keratinocytes function as voltage sensors. 34 Changes in the membrane potential or in extracellular currents, therefore, may affect the activity of these voltage sensors and, in turn, activate signaling cascades.…”

Section: Discussionmentioning

confidence: 99%

Harnessing the Electric Spark of Life to Cure Skin Wounds

Martin-Granados

McCaig

2014

Advances in Wound Care

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“…The surface of normal epidermis has a negative electric potential against the inside [11] and the potential disappears immediately after barrier disruption [12]. Alteration of the skin surface electric potential might be a crucial signal for skin barrier homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Topical Application of Ionic Polymers Affects Skin Permeability Barrier Homeostasis

Denda

Nakanishi

Kumazawa

2004

Skin Pharmacol Physiol

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We previously demonstrated that the external electric potential affected skin barrier homeostasis. On the other hand, topical application of an ionic polymer formed a diffusion electric double layer on the surface of the skin. Thus, we evaluated effects of topical application of ionic polymers on the damaged skin barrier. Application of a nonionic polymer did not affect barrier recovery. Application of sodium salts of anionic polymers accelerated barrier recovery, while that of cationic polymers delayed it. Topical application of a sodium-exchange resin accelerated barrier recovery, but application of a calcium-exchange resin had no effect even when the resins had the same structure. Application of a chloride-exchange resin delayed barrier recovery. Topical application of ionic polymers influenced skin barrier homeostasis.

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Skin Surface Electric Potential Induced by Ion-Flux through Epidermal Cell Layers

Cited by 45 publications

References 18 publications

Immunoreactivity of VR1 on Epidermal Keratinocyte of Human Skin

Immunoreactivity of VR1 on Epidermal Keratinocyte of Human Skin

Harnessing the Electric Spark of Life to Cure Skin Wounds

Topical Application of Ionic Polymers Affects Skin Permeability Barrier Homeostasis

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