Skin sympathetic nerve activity and the temporal clustering of cardiac arrhythmias

Kusayama, Takashi; Jiang, Wan; Doytchinova, Anisiia; Wong, Johnson; Kabir, Ryan; Mitscher, Gloria A.; Straka, Susan; Shen, Changyu; Everett, Thomas H.; Chen, Peng Sheng

doi:10.1172/jci.insight.125853

Cited by 43 publications

(31 citation statements)

References 40 publications

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“…Sympathetic nerve traffic can be quantified using microneurography [ 29 , 48 – 50 ], in which microelectrodes are inserted into peripheral nerves (median or common peroneal) to record from sympathetic axon bundles [ 29 , 48 – 52 ]. The relatively recent introduction of non-invasive skin sympathetic nerve activity (SKNA) recordings provides a means of overcoming some of the logistical limitations of invasive microneurography [ 30 – 32 , 51 ]. Subcutaneous nerve activity recorded from the chest wall of dogs correlates with nerve activity within stellate ganglion and corresponding sympathetic nervous effects on the heart [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…This SKNA is reportedly a more sensitive index of cardiac sympathetic tone than heart rate variability derived measures [ 53 ]. Validation studies in humans have established the sensitivity of SKNA recordings to autonomic challenges in healthy individuals, to lidocaine deactivation of stellate ganglion, to vagus nerve stimulation, and to pathological changes in cardiac rhythm [ 30 , 32 , 51 ]. As a measure of multiunit sympathetic activity relevant to cardiovascular control, the research potential of this approach is exciting.…”

Section: Discussionmentioning

confidence: 99%

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Absence of reliable physiological signature of illusory body ownership revealed by fine-grained autonomic measurement during the rubber hand illusion

2021

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The neural representation of a ‘biological self’ is linked theoretically to the control of bodily physiology. In an influential model, selfhood relates to internal agency and higher-order interoceptive representation, inferred from the predicted impact of efferent autonomic nervous activity on afferent viscerosensory feedback. Here we tested if an altered representation of physical self (illusory embodiment of an artificial hand) is accompanied by sustained shifts in autonomic activity. Participants (N = 37) underwent procedures for induction of the rubber hand illusion (synchronous stroking of own unseen hand and observed stroking of artificial hand) and a control condition (asychronous stroking). We recorded electrocardiography, electrodermal activity, and a non-invasive measure of multiunit skin sympathetic nerve activity (SKNA) from the chest. We compared these autonomic indices between task conditions, and between individuals who did and did not experience the illusion. Bayes factors quantified the strength of evidence for and against null hypotheses. Observed proprioceptive drift and subjective reports confirmed the efficacy of the synchronous (vs asynchronous) condition in inducing illusory hand ownership. Stringent discriminant analysis classified 24/37 individuals as experiencing the rubber hand illusion. Surprisingly, heart rate, heart rate variability, electrodermal activity, and SKNA measures revealed no autonomic differences between synchronous vs asynchronous conditions, nor between individuals who did or did not experience the rubber hand illusion. Bayes factors indicated substantial evidence for no physiological differences. In contrast to earlier reports, our autonomic data show the absence of a reliable change in physiological state during the rubber hand illusion. More encompassing perturbations of self-experience, for example in full body illusions, may nevertheless be coupled to, or facilitated by, changes in efferent autonomic activity and afferent viscerosensory feedback. Our findings suggest that such changes in bodily physiology are not sustained as an obligatory component of the rubber hand illusion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Absence of reliable physiological signature of illusory body ownership revealed by fine-grained autonomic measurement during the rubber hand illusion

2021

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“…Literatürdeki son çalışmalar, cilt sempatik sinir aktivitesi (CSSA) olarak adlandırılan yüksek frekanslı sinyallerin insanlarda cilt yüzeyinden invazif olmayanşekilde geniş frekans bant genişligine, yüksek örnekleme frekansına ve düşük gürültü seviyesine sahip bir cihaz vasıtasıyla kaydedilebilecegini göstermektedir [3], [4].İnsanlarda, CSSA ile kardiyovasküler hastalıklar arasındaki ilişkiyi araştıran çalışmalar yeni başlamıştır ve bu çalışmalar CSSA ile kardiyak aritmiler arasındaki ilişkiyi araştırmıştır [3], [4]. Ancak, ME'nin güvenilir teşhisi için güncel makine ögrenmesi tekniklerini kullanarak CSSA'daki anomalileri tespit eden bir çalışma henüz bulunmamaktadır.…”

Section: Introductionunclassified

Detection of Myocardial Infarction using Autonomic Nervous System, Gaussian Mixture Model and Artificial Neural Network

Terzi

Arikan

2020

2020 Medical Technologies Congress (TIPTEKNO)

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“…Heart rate itself is often used as a rough proxy for sympathetic cardiac influences; heart rate typically increases with decreasing heart rate variability as changes in sympathovagal balance produce cardiovascular arousal. [24,26,42]. As a measure of multiunit sympathetic activity relevant to systemic cardiovascular control, this approach is exciting for both cardiological investigations and for human behavioural psychophysiology.…”

mentioning

confidence: 99%

“…Muscle sympathetic nerve activity shows different patterns of reactivity compared to skin sympathetic, reflecting the dependence on the baroreflex in gating sympathetic vascular control[23]. The relatively recent introduction of non-invasive skin sympathetic nerve activity (SKNA) recordings provides a means of overcoming some of the logistical limitations of invasive microneurography[24][25][26]42]. Subcutaneous nerve activity was initially detected with implanted bipolar electrodes in dogs and, when recorded from the chest wall, was found to correlated with the stellate ganglion nerve activity and sympathetic nervous effects on heart[43].…”

mentioning

confidence: 99%

Absence of reliable physiological signature of illusory body ownership revealed by fine-grained autonomic measurement during the rubber hand illusion

Critchley

Botan

Ward

2020

Preprint

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The neural representation of a ‘biological self’ is linked theoretically to the control of bodily physiology. In an infleuntial model, selfhood relates to internal agency and higher-order interoceptive representation, inferred from the predicted impact of efferent autonomic nerves on afferent viscerosensory feedback. Here we tested if an altered representation of physical self (illusory embodiment of an artificial hand) is accompanied by sustained shifts in autonomic activity.Participants (N=37) underwent procedures for induction of the rubber hand illusion (synchronous stroking of own unseen hand and observed stroking of artificial hand) and a control condition (asychronous stroking). We recorded electrodermal activity, electrocardiography, and non-invasive measurement of multiunit skin sympathetic nerve activity (SKNA) from the chest. We compared measures between task conditions, and between individuals who did and did not experience the illusion. Bayes factors quantified the strength of evidence for and against null hypotheses.Subjective reports and observed proprioceptive drift confirmed the efficacy of synchronous vs asynchronous condition in inducing illusory hand ownership. Stringent discriminant analysis classified 24 /37 individuals as experiencing the rubber hand illusion. Electrodermal activity, heart rate, heart rate variability, and SKNA measures revealed no autonomic differences between synchronous vs asynchronous conditions, nor between individuals who did or did not experience the rubber hand illusion. Bayes factors confirmed there was substantial evidence for no physiological differences.In contrast to earlier reports, our cardiac and electrodermal autonomic data, including fine grained SKNA measurement, provide substantial evidence for the absence of a reliable change in physiological state during induction or experience of the rubber hand illusion. If illusory body ownership is coupled to, or facilitated by, changes in efferent autonomic activity and afferent viscerosensory feedback, our findings suggest that such changes in bodily physiology are not sustained as an obligatory component of the illusion.

show abstract

Skin sympathetic nerve activity and the temporal clustering of cardiac arrhythmias

Cited by 43 publications

References 40 publications

Absence of reliable physiological signature of illusory body ownership revealed by fine-grained autonomic measurement during the rubber hand illusion

Absence of reliable physiological signature of illusory body ownership revealed by fine-grained autonomic measurement during the rubber hand illusion

Detection of Myocardial Infarction using Autonomic Nervous System, Gaussian Mixture Model and Artificial Neural Network

Absence of reliable physiological signature of illusory body ownership revealed by fine-grained autonomic measurement during the rubber hand illusion

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