“…Studies evaluating the correlation between objective temperature measurements and CO showed conflicting results; some observed moderate correlations [33,35,40], whereas most observed no correlation [34–38]. Skin temperature measurement methods differ widely and are likely influenced by several factors: age, ambient temperature, hypothermia, peripheral vascular disease, vasopressors, pain and anxiety have all been proposed as influencing circumstances [44,45]. This may explain the conflicting results and may limit its usefulness for estimating CO in clinical practice.…”