Skin testing technique and precision in stinging insect allergy

Corallino, Massimo; Nico, Andrea; Kourtis, Georgios; Caiaffa, Maria Filomena; Macchia, Luigi

doi:10.1111/j.1365-2702.2007.01842.x

Cited by 15 publications

(20 citation statements)

References 15 publications

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“…It should be strongly emphasized that venom skin testing requires highly experienced staff to achieve highly repeatable results [9]. In patients with a negative SPT, it is therefore recommended to confirm this result in IDT.…”

Section: Discussionmentioning

confidence: 99%

Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines

Cichocka‐Jarosz¹,

Diwakar²,

Brzyski³

et al. 2011

aoms

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IntroductionVenom immunotherapy (VIT) practice is the definitive treatment for patients with potentially fatal allergic reactions to Hymenoptera stings. The aim is assesing compliance of VIT practice in Poland with the current European Academy of Allergy and Clinical Immunology (EAACI) guidance.Material and methodsA multicentre study was carried out using a structured questionnaire which was sent by post to all VIT practitioners in Poland. Some questionnaire items were altered, in comparison to original version by adding additional answer options or alowing multiple answer option. The response rate was 100%. The obtained results were compared with the published EAACI guidelines.ResultsTwenty-six Polish centres took part in the survey. SSIgE and skin prick tests (SPT) are together used as the first line of investigation, whereas confirmatory intradermal tests (IDT) are applied in half of centres. Only a few centres measure baseline serum tryptase levels. The ultra-rush protocol is preferred. Antihistamine pre-medication is routinely practiced. A target dose equal to 100 µg is used in most centres. A 6-week interval between booster doses is the most frequent. Five years is considered as an optimal VIT duration. Before the VIT completion, SSIgE is evaluated in fifty percent of centres, whereas sting challenge is considered by half of responders.ConclusionsThere are some differences between current practice in Poland and the EAACI recommendations, indicating areas requiring better compliance. Comparision between Poland and the United Kingdom revealed that health service organization and health care funding may play a major role in the provision of allergy services. This may affect the extent to which international guidance may be applied in individual countries. It is worth considering conducting the same survey in other European countries.

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Section: Discussionmentioning

confidence: 99%

Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines

Cichocka‐Jarosz¹,

Diwakar²,

Brzyski³

et al. 2011

aoms

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show abstract

“…Intradermal tests should be performed even in cases of a positive prick test result in order to correctly identify a cutaneous endpoint for follow-up of VIT. Correct performance of skin tests with hymenoptera venom is of crucial importance, both to ensure an accurate diagnosis and to monitor VIT [92]. In particular, intradermal tests should be carried out with 0.02 mL of the allergenic extract injected into the dermis to generate a wheal of approximately 3 mm in diameter.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

Hymenoptera Venom Allergy: Management of Children and Adults in Clinical Practice

Bilò

Pravettoni

Bignardi

et al. 2019

J Investig Allergol Clin Immunol

115

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Hymenoptera venom allergy is an epidemiologically underestimated condition representing an important cause of morbidity worldwide. Preventing future allergic reactions in patients who have developed a systemic reaction is based on the correct management of emergency followed by a correct diagnosis, prescription of adrenaline autoinjectors and, where indicated, specific venom immunotherapy (VIT). Some epidemiological studies highlight the poor knowledge of this disease and the frequent inadequacy of its management. Moreover, they emphasize the importance of such a life-saving treatment as specific immunotherapy. The availability of high quality Hymenoptera venom extracts for diagnostic and therapeutic use has dramatically improved the prognosis and the quality of life of allergic patients. The subcutaneous VIT represents the most effective form of immunotherapy with allergen presently available, with a carry-over effect lasting up to several years after its interruption. This report on the management of children and adults allergic to Hymenoptera venom was drawn up by a panel of Italian experts. The main objective of this consensus is to review the scientific evidences related to diagnosis, therapy and management of patients allergic to Hymenoptera venom and is aimed to improve the knowledge about this disease and promote good clinical practices. Practical suggestions for a correct diagnosis, prescription of emergency therapy and immunotherapy, as well as strategies for taking care of patients´ management are included.

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“…Cut-off for positivity is the appearance of a wheal of ≥ 3 mm diameter compared to the negative control in the pricked area after 15-20 minutes (35). Regardless of SPT results, it is recommended to also perform intradermal testing (IT); briefly, venom extracts, serially diluted to reach end concentrations ranging from 0.001 to 1 µg/mL, are administered at increasing concentrations with intradermal needle injection (5).…”

Section: F O R P U B B L I C a T mentioning

confidence: 99%

Clinical aspects of hymenoptera venom allergy and venom immunotherapy

Bilò

Tontini

Martini

et al. 2019

Eur Ann Allergy Clin Immunol

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Skin testing technique and precision in stinging insect allergy

Abstract: Diagnosis of allergic diseases and monitoring of immunotherapy largely rely on impeccable skin testing technique.

Cited by 15 publications

References 15 publications

Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines

Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines

Hymenoptera Venom Allergy: Management of Children and Adults in Clinical Practice

Clinical aspects of hymenoptera venom allergy and venom immunotherapy

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