Skin Thickness Changes in Normal Aging Skin

Branchet, M.‐C.; Boisnic, S; Françès, Camille; Robert, A.M.

doi:10.1159/000213172

Cited by 221 publications

(152 citation statements)

References 12 publications

Supporting

Mentioning

137

Contrasting

Unclassified

Order By: Relevance

“…As previously stated, however, all hormone-de®cient patients were receiving adequate substitution therapy. Epidermal thickness has been shown to decrease with age at a magnitude of approximately 6±7% per decade (17). The epidermal thickness found in the controls in the present study is comparable to that previously reported in healthy individuals of similar age (17).…”

Section: Discussionsupporting

confidence: 89%

“…Epidermal thickness has been shown to decrease with age at a magnitude of approximately 6±7% per decade (17). The epidermal thickness found in the controls in the present study is comparable to that previously reported in healthy individuals of similar age (17). In the present study, the GH-treated patients were comparable in age with the controls.…”

Section: Discussionsupporting

confidence: 88%

“…In our material the dermis in the patients with acromegaly was so thick that it extended throughout the depth of the biopsy sample, rendering exact measurements impossible. In the present study, the age difference between the acromegalic patients and the controls was rather large, and the ®nding of a tendency towards thinner epidermis in the acromegalic patients may therefore simply have been a re¯ection of the age difference (17).…”

Section: Discussionmentioning

confidence: 49%

See 2 more Smart Citations

Skin morphological changes in growth hormone deficiency and acromegaly

Lange

Thulesen

Feldt‐Rasmussen

et al. 2001

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To evaluate the histomorphology of skin and its appendages, especially eccrine sweat glands, in patients with GH disorders, because reduced sweating ability in patients with growth hormone de®ciency (GHD) is associated with increased risk of hyperthermia under stressed conditions. Design and methods: A skin biopsy was obtained from 17 patients with GHD treated with GH, ®ve patients with untreated GHD, 10 patients with active acromegaly and 13 healthy controls. Results: The sweat secretion rate (SSR) was signi®cantly decreased in both the untreated (median 41 mg/30 min, range 9±79 mg/30 min) and the GH-treated (median 98 mg/30 min, range 28± 147 mg/30 min) patients with GHD compared with that in controls (median 119 mg/30 min, range 90±189 mg/30 min; P 0X001 and 0.01 respectively). Epidermal thickness was signi®cantly decreased in both untreated (median 39 mm, range 28±55 mm) and GH-treated patients with GHD (median 53 mm, range 37±100 mm), compared with that in controls (median 66 mm, range 40± 111 mm; P , 0X02X A statistically non-signi®cant tendency towards thinner epidermis (median 59 mm, range 33±83 mm) was recorded in acromegalic patients P 0X08 compared with controls. There was no signi®cant difference in the area of the sebaceous glands in the biopsies between the three groups and the controls. The area of eccrine sweat gland glomeruli was signi®cantly decreased in the untreated patients with GHD (median 16407 mm 2 , range 12758±43976 mm 2 ) compared with that in controls (median 29446 mm 2 , range 13511±128661 mm 2 ; P 0X03Y but there was no signi®cant difference between the GH-treated patients with GHD and controls. Conclusions: We conclude that GH, either directly or via IGF-I, may have both a structural and a functional effect on human skin and its appendages, and that patients with GHD have histomorphological changes in skin compared with controls. Importantly, these changes are not fully reversed despite long-term and adequate GH treatment in patients with childhood onset GHD.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 49%

See 1 more Smart Citation

Skin morphological changes in growth hormone deficiency and acromegaly

Lange

Thulesen

Feldt‐Rasmussen

et al. 2001

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…In skin, for example, the outer epidermal layer is pigmented by melanin which absorbs strongly in the UV while the inner dermal layer is pigmented by blood which absorbs in the visible and near-infrared parts of the spectrum [26]. Furthermore, the thickness of the epidermal layer may vary with anatomical location, gender, and age [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Rapid and accurate estimation of blood saturation, melanin content, and epidermis thickness from spectral diffuse reflectance

Yudovsky

Pilon

2010

Appl. Opt.

View full text Add to dashboard Cite

This paper presents a method to determine chromophore concentrations, blood saturation, and epidermal thickness of human skin from diffuse reflectance spectra. Human skin was approximated as a plane-parallel slab of variable thickness supported by a semi-infinite layer corresponding to the epidermis and dermis, respectively. The absorption coefficient was modeled as a function of melanin content for the epidermis and blood content and oxygen saturation for the dermis. The scattering coefficient and refractive index of each layer were found in the literature. Diffuse reflectance spectra between 490 and 620 nm were generated using Monte Carlo simulations for a wide range of melanosome volume fraction, epidermal thickness, blood volume, and oxygen saturation. Then, an inverse method was developed to retrieve these physiologically meaningful parameters from the simulated diffuse reflectance spectra of skin. A previously developed accurate and efficient semi-empirical model for diffuse reflectance of two layered media was used instead of time-consuming Monte Carlo simulations. All parameters could be estimated with relative root mean squared error less than 5% for (i) melanosome volume fraction ranging from 1 to 8%, (ii) epidermal thickness from 20 to 150 µm, (iii) oxygen saturation from 25 to 100%, (iv) blood volume from 1.2 to 10%, and (v) tissue scattering coefficient typical of human skin in the visible part of the 1 spectrum. Similar approach could be extended to other two-layer absorbing and scattering system.

show abstract

“…From a macroscopic point of view, aged skin differs from young skin with regard to wrinkles, elasticity, thickness (3,4), and surface pattern (5). Microscopic and biochemical analyses of aged skin indicate that the living epidermis comprises a smaller number of layers and that the dermal-epidermal junction is attened (5).…”

Section: Aging Of Human Skinmentioning

confidence: 99%

Aging of Human Skin: Review of a Mechanistic Model and First Experimental Data

et al. 2000

View full text Add to dashboard Cite

SummaryThe physical, chemical, and biochemical factors that accelerate skin aging have been proposed to activate a self-maintained microin ammatory process, one of the expected end results of which is an imbalance in the turnover of macromolecules in the dermis. Surface peroxides are recognized as controllable factors of skin aging, and their accumulation is attributed to environmentally induced impairment of defense enzymes. Topical application of antioxidants decreases the rate at which skin elasticity and skin thickness are modi ed.

show abstract

Skin Thickness Changes in Normal Aging Skin

Cited by 221 publications

References 12 publications

Skin morphological changes in growth hormone deficiency and acromegaly

Skin morphological changes in growth hormone deficiency and acromegaly

Rapid and accurate estimation of blood saturation, melanin content, and epidermis thickness from spectral diffuse reflectance

Aging of Human Skin: Review of a Mechanistic Model and First Experimental Data

Contact Info

Product

Resources

About