Skin tissue regeneration for burn injury

Shpichka, Anastasia; Butnaru, Denis; Безруков, Е. А.; Sukhanov, Roman; Atala, Anthony; Бурдуковский, В. Ф.; Zhang, Yuanyuan; Timashev, Peter

doi:10.1186/s13287-019-1203-3

Cited by 288 publications

(195 citation statements)

References 225 publications

(148 reference statements)

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“…For example, insufficient blood supply (ischemia), infection, residual necrotic material, inadequate inflammatory or immune responses, or radiation injury may hamper the processes of epithelialization [3]. Intrinsic signals are activated in the epidermis and adjacent tissues, and they are modulated by multiple factors, including cytokines or growth factors, cellular receptors, matrix metalloproteinases (MMPs), and extracellular matrix components [14]. Complex interactions and crosstalk between keratinocytes, fibroblasts, inflammatory cells, and epidermal SCs are critical for wound closure [15].…”

Section: Epithelialization In Skin Wound Involves Complex Inflammatormentioning

confidence: 99%

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

et al. 2020

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The skin, which serves as the first barrier of the human body, is particularly susceptible to exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are commonly observed in clinics. Healing of skin wounds is a complex process, consisting of infiltration of inflammatory cells, cellular proliferation, and tissue remodeling phases, which restore the integrity and functions of the skin. Epithelialization is involved in wound healing through re-establishing an intact keratinocyte layer. Epidermal stem cells are indispensable for epithelialization, and they are regulated by multiple proinflammatory cytokines or growth factors. In this review, we summarize recent advances in the effect of these cytokines on migration, proliferation, and differentiation processes of epidermal stem cells. We also introduce promising therapeutic strategies targeting epidermal stem cells or related proinflammatory cytokines for patients with skin wounds.

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Section: Epithelialization In Skin Wound Involves Complex Inflammatormentioning

confidence: 99%

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

et al. 2020

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“…In this context, autologous or allogenic stem cell therapies might emerge as a promising and effective treatment strategy both for wound healing and systemic effects of the burns such as inflammation, hypermetabolism and immune suppression. Various stem cell types from different sources, especially MSCs have been investigated for this purpose [127]. A phase-1 clinical trial (NCT02104713) collaborated by United States Department of Defense aims to investigate the safety of allogenic MSC application to second degree burn wounds.…”

Section: Burn Injurymentioning

confidence: 99%

Therapeutic Applications of Stem Cells and Extracellular Vesicles in Emergency Care: Futuristic Perspectives

Öztürk

Elçin

Koca

et al. 2020

Stem Cell Rev and Rep

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Regenerative medicine (RM) is an interdisciplinary field that aims to repair, replace or regenerate damaged or missing tissue or organs to function as close as possible to its physiological architecture and functions. Stem cells, which are undifferentiated cells retaining self-renewal potential, excessive proliferation and differentiation capacity into offspring or daughter cells that form different lineage cells of an organism, are considered as an important part of the RM approaches. They have been widely investigated in preclinical and clinical studies for therapeutic purposes. Extracellular vesicles (EVs) are the vital mediators that regulate the therapeutic effects of stem cells. Besides, they carry various types of cargo between cells which make them a significant contributor of intercellular communication. Given their role in physiological and pathological conditions in living cells, EVs are considered as a new therapeutic alternative solution for a variety of diseases in which there is a high unmet clinical need. This review aims to summarize and identify therapeutic potential of stem cells and EVs in diseases requiring acute emergency care such as trauma, heart diseases, stroke, acute respiratory distress syndrome and burn injury. Diseases that affect militaries or societies including acute radiation syndrome, sepsis and viral pandemics such as novel coronavirus disease 2019 are also discussed. Additionally, featuring and problematic issues that hamper clinical translation of stem cells and EVs are debated in a comparative manner with a futuristic perspective.

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“…Epidermal SCs are skin stem cells whose origins may be heterogeneous or autogenous. Many studies have explored wound healing therapies that use SCs [16].…”

Section: Cutaneous Wound Healingmentioning

confidence: 99%

Anti-Aging Effects of GDF11 on Skin

Rochette

Mazini

Méloux

et al. 2020

IJMS

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Human skin is composed of three layers: the epidermis, the dermis, and the hypodermis. The epidermis has four major cell layers made up of keratinocytes in varying stages of progressive differentiation. Skin aging is a multi-factorial process that affects every phase of its biology and function. The expression profiles of inflammation-related genes analyzed in resident immune cells demonstrated that these cells have a strong ability to regenerate adult skin stem cells and to produce endogenous substances such as growth differentiation factor 11 (GDF11). GDF11 appears to be the key to progenitor proliferation and/or differentiation. The preservation of youthful phenotypes has been tied to the presence of GDF11 in different human tissues, and, in the skin, this factor inhibits inflammatory responses. The protective role of GDF11 depends on a multi-factorial process implicating various types of skin cells such as keratinocytes, fibroblasts and inflammatory cells. GDF11 should be further studied for the purpose of developing novel therapies for the treatment of skin diseases.

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Skin tissue regeneration for burn injury

Cited by 288 publications

References 225 publications

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

Therapeutic Applications of Stem Cells and Extracellular Vesicles in Emergency Care: Futuristic Perspectives

Anti-Aging Effects of GDF11 on Skin

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