Skin tissue repair materials from bacterial cellulose by a multilayer fermentation method

Fu, Lei; Zhang, Yue; Li, Chao; Wu, Zhihong; Zhuo, Qin; Huang, Xuejun; Qiu, Guixing; Zhou, Ping; Yang, Guang

doi:10.1039/c2jm00134a

Cited by 118 publications

(78 citation statements)

References 39 publications

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“…Therapeutic feasibility is dependent on the skin compatibility of these supports; however, little information is available concerning the skin compatibility and irritation potential of BC-based biomaterials. Cytotoxicity studies have been conducted with human cells [9][10][11]. However, reports regarding in vivo biocompatibility are rather scarce and mainly used mice surgeries [9,11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Cytotoxicity studies have been conducted with human cells [9][10][11]. However, reports regarding in vivo biocompatibility are rather scarce and mainly used mice surgeries [9,11,12]. Clinical tests have been conducted with commercial biocellulose films mainly for wound healing effect [13] which account for their dermal compatibility, but this parameter has not been objectively characterized.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

Almeida

Pereira

Silva

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

189

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a b s t r a c tBacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membranes with and without glycerin (acting as plasticizer) were tested. No significant differences were observed for transepidermal water loss (TEWL) measurements in comparison with negative control, 2 and 24 h after patch removal, which is an indicator of an absence of barrier disruption. Similar results were found for erythema. Clinical scores were zero at both times for all volunteers, with the exception of five volunteers that exhibited weak reactions. BC with glycerin provided a skin moisturizing effect statistically higher than the negative control (p = 0.044), which was not observed for BC alone. The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery. Besides modifying the mechanical properties, the inclusion of glycerin results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness, such as psoriasis and atopic dermatitis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

Almeida

Pereira

Silva

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

189

View full text Add to dashboard Cite

show abstract

“…A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT (2) The strain-rate-sensitivity exponent at each strain was determined based on equation (2) using a linear least-square method. Variation of with the strain rate at strain levels from 10% to 50% was numerically calculated (see in Fig.…”

Section: Strain-rate-sensitivitymentioning

confidence: 99%

“…1). A growing interest to BC hydrogels is mainly thanks to their ideal * Both XG and ZS have equal contributions to the paper and are co-first authors biocompatibility [1] , making it a biomaterial suitable for various applications, such as components for wound dressing [2,3] , drug-delivery systems [4] , etc. Recently, their applications in biomedical science attracted an increasing attention, such as artificial blood vessels [5,6], regeneration of damaged peripheral nerves [7], implant tissues for ear-cartilage replacement [8], etc.…”

Section: Introductionmentioning

confidence: 99%

Effect of microstructure on anomalous strain-rate-dependent behaviour of bacterial cellulose hydrogel

Gao

Shi

Lau

et al. 2016

Materials Science and Engineering: C

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This study is focused on anomalous strain-rate-dependent behaviour of bacterial cellulose (BC) hydrogel that can be strain-rate insensitive, hardening, softening, or strain-rate insensitive in various ranges of strain rate. BC hydrogel consists of randomly distributed nanofibres and a large content of free water; thanks to its ideal biocompatibility, it is suitable for biomedical applications. Motivated by its potential applications in complex loading conditions of body environment, its time-dependent behaviour was studied by means of inaqua uniaxial tension tests at constant temperature of 37°C at various strain rates ranging from 0.0001 s -1 to 0.3 s -1 . Experimental results reflect anomalous strain-rate-dependent behaviour that was not documented before. Micro-morphological observations allowed identification of deformation mechanisms at low and high strain rates in relation to microstructural changes. Unlike strain-rate softening behaviours in other materials, reorientation of nanofibres and kinematics of free-water flow dominate the softening behaviour of BC hydrogel at high strain rates.

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“…Because of its unique properties such as a high mechanical strength, high permeability, high water-holding capacity, Fig. 6 Employment of a microbe as designed cell factory for production of functional metabolites considerable biocompatibility, and non-toxicity, BC can be used as scaffold for various tissue engineering applications such as the development of cartilage [114], skin [115,116], dental implants [117], nerve conduits [118], and blood vessels [119,120], etc. To further explore the applications of BC in biomedical field, one promising strategy is to make BC with similar ordered structure with natural tissue or organ, or guide the cell alignment to form ordered multicellular structures, and finally, make the artificial tissues or organs perform their functions.…”

Section: Microbial Cell Factories: Manufacturing Functional Metabolitesmentioning

confidence: 99%

Fabrication of nanocomposites and hybrid materials using microbial biotemplates

Shi

Ullah

et al. 2017

Adv Compos Hybrid Mater

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Microbes are important part of life that vary in sizes and shapes, diverse surface chemistry and biology, and porous nature of their cell walls. Besides their importance in industrial processes such as fermentation, these serve as biotemplates and provide a biomimetic approach for fabrication of multifarious complex constructs with predefined features, ordered composites and hybrid nanomaterials, microdevices, and micro/nanorobots through various strategies. The template or building blocks for such approaches can be bacterial, algal, and fungal cells or virus particles. Here, we have summarized recent advancements in biofabrication based on live microbes. Using engineering approaches and suitable methods, live microbes can be manipulated as functional Bmicro/nanodevices and -robots^to further perform biological functions such as replication, distribution, motility, formation of colonies, and secretion of metabolites at will. Biofabrication based on microbes provides effective methods to control and manipulate microbes as functional live building blocks to create micro/nanodevices and -robots for biomedical and energy applications.

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Skin tissue repair materials from bacterial cellulose by a multilayer fermentation method

Cited by 118 publications

References 39 publications

Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

Effect of microstructure on anomalous strain-rate-dependent behaviour of bacterial cellulose hydrogel

Fabrication of nanocomposites and hybrid materials using microbial biotemplates

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