Skin toxicity of surfactants: Structure/toxicity relationships

Lemery, Emmanuelle; Briançon, Stéphanie; Chevalier, Yves; Bordes, Claire; Oddos, Thierry; Gohier, Annie; Bolzinger, Marie‐Alexandrine

doi:10.1016/j.colsurfa.2015.01.019

Cited by 116 publications

(55 citation statements)

References 52 publications

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“…In this study, we measured the CMC and found that SLS was slightly lower than previous reports of 0.2% (Lémery et al, 2015) and 0.23% (Khan and Shah, 2008), and the result obtained with BC was similar to that obtained previously, at 0.02% (Deutschle et al, 2006).…”

Section: Comparison Of Cmc and Ic 50supporting

confidence: 88%

Predicting the results of a 24-hr human patch test for surfactants: utility of margin-setting in a reconstructed human epidermis model

et al. 2019

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To predict the results of a 24-hr closed human patch test, we previously recommended the use of in vitro test with a reconstructed human epidermis (RhE) model adopted in OECD TG 439, and proposed the margin method, which includes evaluation of twice the concentration to avoid a false positive for surfactants. Therefore, in this study, we used LabCyte EPI-MODEL as a RhE model, and confirmed the reproducibility of this method using five surfactants, including benzalkonium chloride (BC), sodium lauryl sulfate (SLS), and lauryl betaine (LB), for which false negative results have previously been reported, and three different surfactants. For all surfactants, prediction of patch test results using a margin of two revealed that human tests could be performed safely, confirming the utility of the margin method. In addition, we examined the relationship with critical micellar concentration (CMC). The IC 50 for cell viability in the RhE model for three types of surfactants (BC, SLS, and LB) was 2.7-to 49.7-times the CMC. Therefore, the range of concentrations in which tests were performed with the present method was within the range of concentrations with high cleansing. Furthermore, we examined the relationship between cell viability and release of the inflammatory mediator interleukin-1α (IL-1α). IL-1α release was associated with cell viability, supporting the results of the human patch test. that the result of a patch test is "non-irritant" if an in vitro test performed with a concentration twice as high as the test concentration has a survival rate exceeding 50%

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Section: Comparison Of Cmc and Ic 50supporting

confidence: 88%

Predicting the results of a 24-hr human patch test for surfactants: utility of margin-setting in a reconstructed human epidermis model

et al. 2019

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“…Some authors tested the cytotoxicity and inflammation potency of several surfactants on reconstructed human epidermis tissues, and concluded that PEG ethers appeared to be more toxic than PEG esters. The results also revealed the mildness of polyoxyethylene sorbitan esters independently of their alkyl chain length [62]. Frequently, the cleansing and leave-on products contain up to 20% and 5% PEG-20 glyceryl triisostearate, respectively [61].…”

Section: In Vivo Antipsoriatic Activitymentioning

confidence: 85%

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

et al. 2020

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Human neutrophil elastase (HNE) is a serine protease that degrades matrix proteins. An excess of HNE may trigger several pathological conditions, such as psoriasis. In this work, we aimed to synthesize, characterize and formulate new HNE inhibitors with a 4-oxo-β-lactam scaffold with less toxicity, as well as therapeutic index in a psoriasis context. HNE inhibitors with 4-oxo-β-lactam scaffolds were synthesized and characterized by NMR, FTIR, melting point, mass spectrometry and elemental analysis. In vitro cytotoxicity and serine protease assays were performed. The compound with the highest cell viability (AAN-16) was selected to be incorporated in an emulsion (AAN-16 E) and in a microemulsion (AAN-16 ME). Formulations were characterized in terms of organoleptic properties, pH, rheology, droplet size distribution, in vitro drug release and in vivo psoriatic activity. All compounds were successfully synthesized according to analytical methodology, with good yields. Both formulations presented suitable physicochemical properties. AAN-16 E presented the most promising therapeutic effects in a murine model of psoriasis. Overall, new HNE inhibitors were synthesized with high and selective activity and incorporated into topical emulsions with potential to treat psoriasis.

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“…S8). This is probably due to the neutralization effect of positively charged surfactant head groups, because usually cationic surfactants have higher toxicity as compared to nonionic ones [67,68]. interactions.…”

Section: Dna Transfectionmentioning

confidence: 99%

Structural, biocomplexation and gene delivery properties of hydroxyethylated gemini surfactants with varied spacer length

Zakharova

Gabdrakhmanov

Ibragimova

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Skin toxicity of surfactants: Structure/toxicity relationships

Cited by 116 publications

References 52 publications

Predicting the results of a 24-hr human patch test for surfactants: utility of margin-setting in a reconstructed human epidermis model

Predicting the results of a 24-hr human patch test for surfactants: utility of margin-setting in a reconstructed human epidermis model

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

Structural, biocomplexation and gene delivery properties of hydroxyethylated gemini surfactants with varied spacer length

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