Skin tumors and skin infections in kidney transplant recipients vs. patients with pemphigus vulgaris

Sharquie, Khalifa E.; Noaimi, Adil A.; Al-Jobori, Ali A.

doi:10.1111/j.1365-4632.2012.05708.x

Cited by 9 publications

(9 citation statements)

References 22 publications

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“…Sharquie et al . concluded that PV in prolonged immunosuppression is immunoprotective against skin infections and skin tumors compared with kidney transplant recipients . Therefore, from these above opinions, we think it may be merely a secondary infection due to his abuse of oral antimicrobials, lack of shampoo, and accumulation of lots of fatty scales.…”

Section: Localized Pemphigus Vulgaris On the Scalpmentioning

confidence: 91%

Pemphigus vulgaris with vegetating feature confined to the scalp

Zhang

Xiao

et al. 2018

Int J Dermatology

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Section: Localized Pemphigus Vulgaris On the Scalpmentioning

confidence: 91%

Pemphigus vulgaris with vegetating feature confined to the scalp

Zhang

Xiao

et al. 2018

Int J Dermatology

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“…In all autoimmune diseases, there should be destruction of some specific tissue induced by autoimmune reaction whether humeral or cell mediated that result in specific diseases like pemphigus, vitiligo and alopecia areata. But on the other hand, these enhanced exaggerated immune reactions could be protective for other specific diseases in the same patients and this idea had been recently supported by Sharquie et al where they found autoimmune diseases like pemphigus and lupus erythematosus are protective against any skin tumors like BCC, SCC and Kaposi's sarcoma and infections like fungal infection warts [6].…”

Section: Discussionmentioning

confidence: 92%

“…From daily clinical practice, we have noticed that many patients with autoimmune disease had lower frequency of infections and skin tumors. Sharquie et al had confirmed this hypothesis especially in relation to pemphigus vulgaris and systemic lupus erythematosus and the results were very encouraging [6]. These results encouraged to conduct a study in patients with vitiligo where it was found that patients with vitiligo had lower frequency of malignancy and this was attributed to high P53 in lesional and perilesional skin compared to normal skin [7].…”

Section: Introductionmentioning

confidence: 90%

Frequency of Benign and Malignant Tumors in Localized Vitiligo in Comparison to Generalized and Universal Vitiligo

Sharquie¹,

Noaimi²,

Murtada³

2016

JCDSA

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Background: Autoimmune diseases like pemphigus and systemic lupus erythematosus are protective against skin malignancies like basal cell carcinoma and squamous cell carcinoma. Objective: As vitiligo is an autoimmune diseases, the aim of the present work is to record the frequency of all benign and malignant skin tumors among patients with different severity of vitiligo and to be compared with the skin tumors in healthy control. Patients and Methods: This is a case series, descriptive study done in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq, during the period from May 2014-May 2015. History was taken from each patient with vitiligo regarding age, gender, duration, personal and family history of vitiligo and other autoimmune diseases such as diabetes mellitus, thyroid dysfunction, and alopecia areata. Patients were assessed for past and present history of photodermatosis and any skin cancers. Healthy control was considered. Results: Three hundred and fifty patients with vitiligo were included in this study: 50 patients with universal vitiligo, 100 patients with generalized vitiligo, and 200 patients with localized vitiligo as well as 500 subjects as a healthy control. The ages of all studied subjects ranged between 31 and 77 years. Twenty four(48%) patients with universal vitiligo were males and 26 (52%) were females; 49(49%) patients with generalized vitiligo were males and 51(51%) were females; 101(50.5%) patients with localized vitiligo were males and 99(49.5%) were females and 235(47%) of control were males and 265(53%) were females. All skin tumors were seen to be high in healthy subjects and lower or absent in patients with vitiligo. Also patients with mild vitiligo had a higher frequency of skin tumors including benign and malignant than patients with severe vitiligo especially in patients with universal vitiligo. In addition, no photosensitivity or actinic reticuloid was detected in patients with vitiligo. Conclusions: Vitiligo especially generalized and universal type as an autoimmune disease had a protective action against photodamage, photosen-* Corresponding author.

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“…So, the present work had confirmed the high positivity of P53 marker in vitiligo skin and its role in protection against skin cancers. A most recent study showed that autoimmune diseases like pemphigus are protective against skin malignancies in kidney transplant recipients [7] and as vitiligo is autoimmune disorder, it might also have such protection.…”

Section: Discussionmentioning

confidence: 99%

“…A most recent study showed that autoimmune diseases like pemphigus vulgaris and systemic lupus erythematous showed absence of skin malignancies among those patients although they had received a prolonged course of immunosuppressive therapy as a result of active immune surveillance in those patients [7]. Also, on a recent study, it was reported that the tumor suppressive marker p53 is increased among patients with vitiligo [8].…”

Section: Introductionmentioning

confidence: 99%