Skin Virilism in Women With Hirsutism

Burton, J.L.; Johnson, Casey; Libman, L. J.; Shuster, Sam

doi:10.1677/joe.0.0530349

Cited by 32 publications

(17 citation statements)

References 11 publications

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“…In the human, differences between clinically normal adult males in plasma T levels are generally moderate and coefficients of variation between 20 and 30% were reported in most studies (11,(28)(29)(30)(31)(32)(33). A diurnal variation in plasma T levels appears consistent but fairly small (34,35).…”

Section: Discussionmentioning

confidence: 93%

Fluctuations in Plasma Testosterone Levels in Adult Male Rats and Mice

et al. 1973

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Testosterone (T) levels in the plasma of male laboratory rats and mice were measured by radioimmunoassay. There was a striking individual variation with values ranging from less than 1 ng/ml to over 30 ng/ml in mice of the same age and strain housed under identical conditions. Using chronic indwelling catheters inserted into a jugular vein, blood was collected from adult conscious male rats every 24 hr for 4 or 8 days and every 30 min for 2 l / 2 or 8 hr. Considerable differences in plasma T levels were observed between different animals, and 2-to S-fold fluctuations of T concentrations in the plasma were detected between samples collected from the same animal at different times. These large and irregular changes in plasma levels of T are unlike the fairly stable levels observed in the human but bear certain resemblance to the pulsatile release of T described in bulls and rams and perhaps also to the social dominance related differences in plasma T levels in Rhesus monkeys. {Endocrinology 92: 1223, 1973

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Section: Discussionmentioning

confidence: 93%

Fluctuations in Plasma Testosterone Levels in Adult Male Rats and Mice

et al. 1973

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“…We have recently shown that other endocrine changes early in life also influence the way in which the adult rat responds to sebotrophic hormones (Thody & Shuster, 1971 b; Thody, Meddis & Shuster, 1977). The early endocrine environment may therefore be important in diseases such as acne and cutaneous virilism ('idiopathic hirsutes') where sebaceous activity is increased (Cunliffe & Shuster, 1969;Burton, Johnson, Libman & Shuster, 1972;Shuster, 1972). We wish to thank Mrs Lyn Carrick and Miss Linda Davison for technical and secretarial assistance.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sex and Age at Gonadectomy on the Sebaceous Response to Progesterone

Shuster¹,

Hinks²,

Thody³

1977

Journal of Endocrinology

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The effect of progesterone on the rate of sebum secretion was examined in intact and gonadectomized rats. In intact, adult, male rats, progesterone administered for 3 weeks decreased sebum secretion; after castration of adult males, progesterone increased sebum secretion and an even greater response occurred in male castrated at 21 days of age. In intact, adult, female rats progesterone slightly increased sebum production. As in the male, the response was affected by the time of gonadectomy, a greater response occurring after spaying at 21 days compared with 10 weeks of age. Thus, the response to progesterone in the adult rat differs in intact males and females and is affected by changes in the endocrine environment induced by gonadectomy, especially near the time of puberty.

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“…(3) 1,178 (7) 1,966 (15) 64 (6) 4.6 (7) 3,057 (3) 87,000 (3) 85 (6) 25 (3) 486,200 (12) 1,413(6) 0(6) 2.0(7) 40.5 (7) 478 (6) 941 (8) 0 (6) 7.1 (15) 105 (15) 568 ( By using a combination of both methods (isotope infusion and direct sampling) Giusti et al (10) obtained a clear picture of androgen origin and secretion in normal women (Fig. 1).…”

Section: Adrenal Oversecretion Of Androgensmentioning

confidence: 99%

“…Starting with the concept that hair follicles as well as sebaceous glands are androgen-dependent structures (2), idiopathic hirsutism has been found to be a condition of local hyperandrogenization that involves increases in hair growth, sweat and sebum secretion, and total skin collagen content (3).…”

Section: Introductionmentioning

confidence: 99%