Skin Wound Healing and Phytomedicine: A Review

Pazyar, Nader; Yaghoobi, Reza; Rafiee, Esmail; Mehrabian, Abolfath; Feily, Amir

doi:10.1159/000357477

Cited by 207 publications

(162 citation statements)

References 69 publications

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“…Besides, it is inhibitory of dipeptidyl peptidase IV in the diabetes management (Bower et al 2014) and its nephropathy and neuropathy complications (Martynyuk et al 2014;Ramachandran et al 2014 (Rašković et al 2014;da Silva Bomfim et al 2015). It is consumed as a functional food with antimicrobial capacity (Nguyen et al 2014) and a phytomedicine for skin wound healing (Pazyar et al 2014). It had inhibition of formalin-induced pain and inflammation in mice (Emami et al 2013) and H 2 O 2 induced oxidative DNA damage in human lymphocytes (Razavi-Azarkhiavi et al 2014).…”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

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Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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“…Wound healing involves a series of complex pathophysiological processes, which includes the inflammation, proliferation and migration of repaired cells, in addition to the formation and tissue remodeling of granulation tissues (9). Factors that are able to disrupt these processes may impact wound Seawater immersion may increase tissue damage; SIBIW is a type of complex and comprehensive damage (11).…”

Section: Discussionmentioning

confidence: 99%

Effect of vacuum sealing drainage on the expression of VEGF and miRNA-17-5p in seawater-immersed blast-injury wounds

Yang¹,

Shi²,

Cao³

2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to compare and observe the expression levels of vascular endothelial growth factor (VEGF) and miRNA-17-5p during the treatment of seawater-immersed blast-injury wounds (SIBIW) under different conditions of vacuum sealing drainage (VSD), and to identify the optimized range of VSD treatment and partially explain its mechanisms. The bilateral hips and scapulae of experimental pigs (weight, 25-30 kg) were subjected to blast-injury wounds, followed by the seawater immersion. The animals then underwent conventional dressing treatment under 120, 180 and 240 mmHg VSD. Visual observation, in addition to histological, immunohistochemical and molecular biological techniques were applied to compare and observe the extent of wound healing and expression levels of VEGF and miRNA-17-5p. The wound healing of the VSD treatment group was improved compared with the control group, with 120 mmHg negative pressure producing the most marked effect. miR-17-5p expression was detected in the SIBIW granulation tissues. There was significant difference between each VSD treatment group and control group at each time point (P<0.05). Thus, the present results show that miR-17-5p can be expressed in SIBIW granulation tissues, and this effect is most evident under 120 mmHg negative pressure, which may inform the optimized negative range for the treatment of SIBIW.

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“…Skin integrity is restored by a physiological process aimed at repairing the damaged tissues. The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling [14]. The time required for complete healing of deep seconddegree burns, without the application of specific therapeutic agents, can be three to six weeks or more, and a scar tissue may appear [15].…”

Section: Discussionmentioning

confidence: 99%