sKlotho is associated with the severity of brick tea-type skeletal fluorosis in China

Liu, Yang; Yang, Yanmei; Wei, Yudan; Liu, Xiaona; Li, Bingyun; Chu, Yanru; Huang, Wei; Wang, Limei; Lou, Qun; Guo, Ning; Wu, Liaowei; Wang, Jian; Zhang, Meichen; Yin, Fanshuo; Fan, Chenlu; Su, Mengyao; Zhang, Zaihong; Zhang, Xin; Gao, Yanhui; Sun, Dianjun

doi:10.1016/j.scitotenv.2020.140749

Cited by 14 publications

(10 citation statements)

References 32 publications

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“…Therefore, previous studies on fluorosis in the TP mainly focused on brick tea, ignoring the endemicity of drinking-type fluorosis, which may mislead fluorosis prevention and treatment in the TP. In addition, it has been confirmed that compared with other fluorosis endemic areas, the same quantity of brick tea fluoride intake in the TP causes more severe fluorosis symptoms (Liu et al 2020 ), which suggests that the superposition of fluoride intake via other pathways, such as through drinking water, makes fluorosis more serious. Unfortunately, to date, no data on the water fluoride concentration in the TP are available in the published literature.…”

Section: Introductionmentioning

confidence: 91%

Spatial–Temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau

Yang

Zhang

et al. 2022

Expo Health

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The Tibetan Plateau (TP) is known as the “Asian Water Tower” and provides vital drinking water for residents of China and Southeast Asian countries. However, large-scale regional research on water quality in this climate-sensitive and ecologically-fragile area is still lacking. Considering that drinking from fluoride-contaminated water poses serious health concerns worldwide, especially in Asian counties, it is urgent to clarify the spatial–temporal distribution characteristics, influencing factors, and health risk of fluoride in surface water in the TP. In this study, a total of 2697 surface water samples from major rivers and typical lakes in the TP were systematically analysed. Overall, fluoride concentrations ranged from 0.003 to 6.240 mg L −1 and varied among water periods, water basins and even water types. Pearson’s correlation analysis showed that the distribution of fluoride concentration was closely related to the regional climate and positively correlated with anthropogenic activities. Probabilistic health risk assessment revealed that potential hazards in the Inner Basin were the highest for all age groups (HR > 1), especially for infants and adults (HR > 3), while the risks in most other water basins were acceptable (HR < 1). Our findings can provide scientific support for fluorosis prevention, and guide water resource utilization in the TP and adjacent regions. Supplementary Information The online version contains supplementary material available at 10.1007/s12403-022-00490-4.

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Section: Introductionmentioning

confidence: 91%

Spatial–Temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau

Yang

Zhang

et al. 2022

Expo Health

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“…Among them, eight articles (37-44) were excluded because they had unclear demographic data or unclear SF or DF results, or the results were not consistent with the theme. Finally, 15 studies were included in the research: 6 studies (27,35,36,(45)(46)(47) that focused on BTF in Tibetan-inhabited areas were included in group 1; 4 studies (27,45,47,48) that discussed the fluoride content of brick tea were included in group 2 (three articles were included in both group 1 and 2); and 8 articles (38,43,(49)(50)(51)(52)(53)(54) were included in group 3 because they primarily discussed the genetic susceptibility of Tibetans to fluorosis.…”

Section: General Database Statisticsmentioning

confidence: 99%

Brick tea consumption and its relationship with fluorosis in Tibetan areas

et al. 2022

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Brick tea-type fluorosis (BTF) due to a high intake of brick tea is possible in Tibetan populations, and dental fluorosis (DF) and skeletal fluorosis (SF) are its primary manifestations. To determine the prevalence of DF and SF and their relationships with brick tea intake in Tibetan populations, a literature review was conducted for studies published between 1994 and 2021. The available evidence revealed that brick tea may be produced from older stems and leaves of the tea plant and that the fluoride content of brick tea exceeds the national standard. The harsh environment of the plateau has led to limited food sources for the local Tibetan people who form the habit of drinking tea leaves as a satiation solution to digest greasy food and replenish vitamins, and regular consumption of brick tea leads to excessive exposure of Tibetan residents to fluoride. Studies in Tibet showed that the prevalence of DF in children was 14.06–75.93% in different districts, and the overall pooled prevalence of DF was 26.08%. The prevalence of SF in adults was 19.90–74.77% in different Tibetan districts, and the overall pooled prevalence of SF was 33.84%. The analysis of risk factors showed that the prevalence of BTF may be related to high-altitude and different working and living conditions, and BTF in children may be associated with fluoride intake during mothers’ pregnancy and lactation. With the development of bioinformatics research, gene polymorphisms were suspected to be related to susceptibility to fluorosis in Tibetan populations. The study of BTF in Tibetan people needs to be further investigated and standardized, and additional studies evaluating the pathogenesis and preventive measures of BTF are warranted.

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“…Therefore, previous studies on uorosis in the TP were mainly focused on brick tea, ignoring the endemic of drinking-type uorosis, which may mislead uorosis prevention and treatment in the TP. In addition, it has been con rmed that compared with other uorosis endemic areas, the same quantity of brick tea uoride intake in the TP causes more severe uorosis symptoms (Liu et al, 2020), which suggests that the superposition of uoride intake via other pathways, such as through drinking water, makes uorosis more serious. Unfortunately, to date, no data on the water uoride concentration in the TP are available in the published literature.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, the distribution of surface water uoride is thought to relate to both natural and anthropological factors. Hydrochemical characteristics in uenced by regional climate, topography and anthropogenic activities Liu et al, 2020;Ma et al, 2021). The temporal and spatial distribution of water resources and changes in water quality caused by climate conditions have generated a lot of research interest from scientists and governments in various countries (Zhang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The Tibetan Plateau (TP) is one of the areas where both brick tea-type uorosis and drinking-type uorosis are prevalent (Lou et al, 2020). Researchers considered drinking brick tea to be the main cause of uorosis in the TP because the average uoride content of brick tea in this area is approximately 800 mg kg −1 , which is far above the national safe threshold of brick tea uoride concentration (300 mg kg −1 ) GB 19965, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Spatial-temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau

Yang

Zhang

et al. 2022

Preprint

View full text Add to dashboard Cite

The Tibetan Plateau (TP) is known as the “Asian Water Tower” and provides vital drinking water for residents of China and Southeast Asian countries. However, large-scale regional research on water quality in this climate-sensitive and eco-fragile area is still lacking. Considering that drinking from fluoride-contaminated water has posed serious health concerns worldwide, especially in Asian counties, it is urgent to clarify the spatial-temporal distribution characteristics, influencing factors, and health risk of fluoride in surface water in the TP. In this study, a total of 2697 surface water samples from major rivers and typical lakes in the TP were systematically analysed. Overall, fluoride concentrations ranged from 0.005 mg L−1 to 6.240 mg L−1 and varied among water periods, water basins and even water types. Pearson’s correlation analysis showed that the distribution of fluoride concentration was closely related to regional climate and positively correlated with anthropogenic activities. Probabilistic health risk assessment revealed that potential hazards in the Inner basin remained highest for all age groups (HR>1), especially for infants and adults (HR>3), while the risks in most other water basins were acceptable (HR < 1). In addition, more than 75% of the residents affected by the surface water in the TP were assessed as having a low fluoride exposure health risk. Our findings can provide scientific support for fluorosis prevention, as well as guide water resource utilization in the TP and adjacent region.

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sKlotho is associated with the severity of brick tea-type skeletal fluorosis in China

Cited by 14 publications

References 32 publications

Spatial–Temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau

Spatial–Temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau

Brick tea consumption and its relationship with fluorosis in Tibetan areas

Spatial-temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau

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