skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo

Bowerman, Bruce; Eaton, Benjamin A.; Priess, James Fl

doi:10.1016/0092-8674(92)90078-q

Cited by 370 publications

(333 citation statements)

References 61 publications

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“…The chosen alleles were skn‐1 (zu135), which contains a premature stop codon in the SKN‐1 DNA‐binding domain, and skn‐1 (zu67), which lacks the regions encoding the SKN‐1A and SKN‐1C isoforms (Bowerman et al ., 1992; Bishop & Guarente, 2007; Johns et al ., 2007; Tullet et al ., 2008). We did not confirm that zu67 produces functional SKN‐1b/c and that this stop codon mutation within the other isoforms does not affect b/c transcription.…”

Section: Resultsmentioning

confidence: 99%

Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans

et al. 2015

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SummaryLactic‐acid bacteria are widely recognized beneficial host associated groups of the microbiota of humans and animals. Some lactic‐acid bacteria have the ability to extend the lifespan of the model animals. The mechanisms behind the probiotic effects of bacteria are not entirely understood. Recently, we reported the benefit effects of Lactobacillus gasseri SBT2055 (LG2055) on animal and human health, such as preventing influenza A virus, and augmentation of IgA production. Therefore, it was preconceived that LG2055 has the beneficial effects on longevity and/or aging. We examined the effects of LG2055 on lifespan and aging of Caenorhabditis elegans and analyzed the mechanism of prolongevity. Our results demonstrated that LG2055 has the beneficial effects on longevity and anti‐aging of C. elegans. Feeding with LG2055 upregulated the expression of the skn‐1 gene and the target genes of SKN‐1, encoding the antioxidant proteins enhancing antioxidant defense responses. We found that feeding with LG2055 directly activated SKN‐1 activity via p38 MAPK pathway signaling. The oxidative stress response is elicited by mitochondrial dysfunction in aging, and we examined the influence of LG2055 feeding on the membrane potential of mitochondria. Here, the amounts of mitochondria were significantly increased by LG2055 feeding in comparison with the control. Our result suggests that feeding with LG2055 is effective to the extend lifespan in C. elegans by a strengthening of the resistance to oxidative stress and by stimulating the innate immune response signaling including p38MAPK signaling pathway and others.

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Section: Resultsmentioning

confidence: 99%

Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans

et al. 2015

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“…Various dimeric combinations of Maf family proteins bind in vitro to a DNA sequence motif called T-MARE (TGCTGA G / C TCAGCA) that contains a TPA-responsive element (TRE; TGA G / C T-CA) (Kataoka et al, 1994a(Kataoka et al, ,b, 1995. The small Maf proteins form heterodimers with a family of bZip proteins that show remarkable homology to two invertebrate proteins, CNC and skn-1, which regulate embryonic development in Drosophila melanogaster and Caenorhabditis elegans, respectively (Mohler et al, 1991(Mohler et al, , 1995Bowerman et al, 1992). This family of factors, referred to as the CNC family, include p45 NF-E2, Nrf1/LCR-F1/TCF-11, Nrf2, and Nrf3, all of which are similar in the bZip domain and form heterodimers with small Maf proteins (Andrews et al, 1993a,b;Chan et al, 1993a,b;Ney et al, 1993;Caterina et al, 1994;Moi et al, 1994;Igarashi et al, 1994Igarashi et al, , 1995Marini et al, 1997;Johnsen et al, 1996;Toki et al, 1997;Kobayashi et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15

et al. 2000

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The transcription factor Bach2, a member of the BTBbasic region leucine zipper (bZip) factor family, binds to a 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive element and the related Maf-recognition element (MARE) by forming homodimers or heterodimers with Maf-related transcription factors. Bach2 regulates transcription by binding to these elements. To understand the function in hematopoiesis, we isolated a cDNA clone for human Bach2 (BACH2) encoding a protein of 841 amino acid residues with a deduced amino acid sequence having 89.5% identity to mouse homolog. Among human hematopoietic cell lines, BACH2 is expressed abundantly only in some B-lymphocytic cell lines. RT ± PCR analysis of hematopoietic cells revealed that BACH2 mRNA is expressed in primary B-cells. Enforced expression of BACH2 in a human Burkitt cell line, RAJI that does not express endogenous BACH2, resulted in marked reduction of clonogenic activity, indicating that BACH2 possesses an inhibitory e ect on cell proliferation. Bȳ uorescent in situ hybridization, the BACH2 gene was localized to chromosome 6q15. Because deletion of the long arm of chromosome 6 (6q) is one of the commonest chromosomal alterations in human B-cell lymphoma, we examined for the loss of heterozygosity (LOH) of the BACH2 gene in human B-cell non-Hodgkin's lymphomas (NHL). Among 25 informative cases, ®ve (20%) showed LOH. These results indicate that BACH2 plays important roles in regulation of B cell development.

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“…We therefore tested each factor in two additional, more sensitive embryonic blastomere conversion assays. RNAi knockdown of skn-1 and pal-1 together blocks specification of the EMS, C, and D founder cells (Bowerman et al 1992;Hunter and Kenyon 1996;Fukushige and Krause 2005). Ectopic expression of either unc-120 or hnd-1 in the skn-1, pal-1 double-RNAi background resulted in widespread myogenesis as assayed by MHCA (Fig.…”

Section: Both Unc-120 and Hnd-1 Are Myogenic In Embryonic Blastomere mentioning

confidence: 99%

Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development

Fukushige¹,

Brodigan²,

Schriefer³

et al. 2006

Genes Dev.

100

164

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Myogenic regulatory factors (MRFs) are required for mammalian skeletal myogenesis. In contrast, bodywall muscle is readily detectable in Caenorhabditis elegans embryos lacking activity of the lone MRF ortholog HLH-1, indicating that additional myogenic factors must function in the nematode. We find that two additional C. elegans proteins, UNC-120/SRF and HND-1/HAND, can convert naïve blastomeres to muscle when overproduced ectopically in the embryo. In addition, we have used genetic null mutants to demonstrate that both of these factors act in concert with HLH-1 to regulate myogenesis. Loss of all three factors results in embryos that lack detectable bodywall muscle differentiation, identifying this trio as a set that is both necessary and sufficient for bodywall myogenesis in C. elegans. In mammals, SRF and HAND play prominent roles in regulating smooth and cardiac muscle development. That C. elegans bodywall muscle development is dependent on transcription factors that are associated with all three types of mammalian muscle supports a theory that all animal muscle types are derived from a common ancestral contractile cell type.[Keywords: Myogenesis; MyoD; SRF; HAND] Supplemental material is avaliable at http://www.genesdev.org.

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skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo

Cited by 370 publications

References 61 publications

Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans

Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans

Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15

Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development

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