Skull Base and Orbital Solitary Plasmacytoma Mimicking a Meningioma

Dang, Sabina; Manzoor, Nauman F.; Harmsen, Hannah; Rivas, Alejandro; Aulino, Joseph M.

doi:10.1001/jamaoto.2019.2797

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Plasmacytoma arises in bone in 70% of patients and soft tissue in the remainder and accounts for 5% of plasma cell neoplasms. 3 Solitary plasmacytoma of bone can accompany multiple myeloma and suggests a more aggressive phenotype. Extramedullary plasmacytoma is a clinically separate entity and is diagnosed in the absence of hypercalcemia, renal function impairment, anaemia, and bone involvement.…”

Section: Discussionmentioning

confidence: 99%

Multiple Upper Aerodigestive Tract Masses Presenting With Stridor—A Rare Case of Aggressive Multifocal Extramedullary Plasmacytoma

2020

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Extramedullary plasmacytomas represent a rare group of B-cell malignancies that arise outside the bone marrow and their disease process is still poorly understood. Here, we will describe a case of a 76-year-old patient who presented with a large chest wall and subglottic mass causing airway compromise and stridor. Biopsies showed atypical plasma cells with prominent nucleoli which were in keeping with an extramedullary plasmacytoma. Disease progressed despite surgical debulking, targeted radiotherapy, and multiple chemotherapy regimens. Although response to treatment is classically good, patients occasionally present with aggressive disease.

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Section: Discussionmentioning

confidence: 99%

Multiple Upper Aerodigestive Tract Masses Presenting With Stridor—A Rare Case of Aggressive Multifocal Extramedullary Plasmacytoma

2020

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Proptosis secondary to a solitary plasmacytoma of the sphenoid bone: a case report on a rare skull base tumour

Seetahal-Maraj

Knight²,

Ramnarine

2022

Egypt J Neurosurg

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Background Plasmacytomas of the skull base are not commonly encountered in clinical practice, with few reported cases in the literature. They form part of the spectrum of plasma cell neoplasms and are classified as a solitary bone plasmacytoma if arising from the sphenoid bone. Its radiographic appearance can lead to misdiagnosis as one of the tumours that are more frequently seen in the skull base, especially meningiomas. Due to the risk of evolution into multiple myeloma, accurate diagnosis is essential. Case presentation A 56-year-old male presented to the emergency department with rapid proptosis and worsening vision in his right eye for one week’s duration. Imaging studies revealed an extra-axial right sphenoid bone tumour with invasion into the temporalis muscle and orbit, leading to significant proptosis. Tumour debulking was done, but there was no improvement in vision postoperatively. Final histology was consistent with a plasmacytoma. The patient was referred to the oncologist for radiation therapy, but subsequently developed further lesions consistent with multiple myeloma. Conclusions Plasmacytomas need to be considered in the differential diagnosis of skull base tumours. Due to their excellent response to radiation, these patients should have early oncology intervention to prevent irreversible neurological deficits.

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Skull Base and Orbital Solitary Plasmacytoma Mimicking a Meningioma

Cited by 2 publications

References 6 publications

Multiple Upper Aerodigestive Tract Masses Presenting With Stridor—A Rare Case of Aggressive Multifocal Extramedullary Plasmacytoma

Multiple Upper Aerodigestive Tract Masses Presenting With Stridor—A Rare Case of Aggressive Multifocal Extramedullary Plasmacytoma

Proptosis secondary to a solitary plasmacytoma of the sphenoid bone: a case report on a rare skull base tumour

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