Skull base cerebrospinal fluid fistula: a novel detection method based on two‐dimensional electrophoresis

Ricchetti, Alma; Burkhard, Pierre; Rodrigo, Neftali; Gamulin, Z.; Côté, Mélanie; Reverdin, A.; Trussart, Catherine; Landis, Basile Nicolas; Lacroix, Jean‐Silvain

doi:10.1002/hed.10359

Cited by 9 publications

(3 citation statements)

References 20 publications

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“…Several noninvasive methods have been proposed for detecting CSF leakage, including testing suspect fluids with reagent sticks used for measuring glucose concentration, 32 the β-2 transferrin test, 33 and the β-trace protein test. 34 As a precaution, sanguineous discharge from the left nostril of the horse described in the present report was tested with a glucose reagent stick. Results were inconclusive, but whether this was because only a small quantity of nasal fluid was available for testing or because of heavy contamination with blood and mucus could not be determined.…”

Section: Equinementioning

confidence: 95%

Pneumocephalus secondary to removal of an osteoma from the paranasal sinuses of a horse

Ragle

Mira²,

Pearson³

et al. 2009

javma

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Section: Equinementioning

confidence: 95%

Pneumocephalus secondary to removal of an osteoma from the paranasal sinuses of a horse

Ragle

Mira²,

Pearson³

et al. 2009

javma

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“…Immunologic methods: Immunologic methods differentiate between proteins in CSF and those in nasopharyngeal secretions 31,32 . Irjala and collegues have described the use of an immunofixation technique for the identification of microaliquots (100 μL) of CSF by demonstrating two electrophoretically characteristic bands of transferrin 33 .…”

Section: Diagnosismentioning

confidence: 99%

CSF rhinorrhea: An overview of endoscopic repair

Sharma¹,

Singh²,

Sinha³

et al. 2010

The Indian Journal of Neurotrauma

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CSF rhinorrhea can be diagnosed with more accurate localizations of the site of leak with the help of modern radiological methods. The repair involves surgical intervention, which has changed from open craniotomy to minimally invasive techniques. Endoscopic repair has gained popularity in last decade and is being practiced by many neurosurgeons either alone or with their ENT colleagues. The overall success rate of endoscopic repairs has triggered several centers to adopt endoscopic repair as first line of treatment of CSF rhinorrhea. However the inexperience of neurosurgeon to sinus anatomy may pose some difficulties with the young neurosurgeons. The article presents a review of the techniques for confirmation of a CSF leak as well as endocscopic repair of CSF fistula.

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“…Средний возраст больных СНЛ, по данным авторов [3], составляет 49,6 года, а индекс массы тела -35,9 кг/м 2 . СНЛ встречается чаще у женщин среднего возраста (81%), страдающих ожирением (94%) [4]. Соотношение мужчин и женщин среди больных СНЛ составляет, по разным данным [3], от 1:1 до 1:2,6.…”

Section: '2014unclassified

Cerebrospinal fluid rhinorrhea as a complication of ACTH-secreting pituitary macroadenoma in a patient with morbid obesity

et al. 2014

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Cushing's disease (CD) is a progressive neuroendocrine disease caused by a pituitary tumor producing excessive amounts of ACTH. In most cases (80-85%) the cause of the disease is a pituitary corticotroph microadenomas (located within the sella, measuring 3–10 mm, rarely multiple microadenomas) and only 15% of cases are presented as corticotroph hyperplasia or pituitary macroadenoma extending beyond the sella. The macroadenomas in CD usually extend suprasellar (10%), infrasellar tumor growth is relatively rare (5%). If the clinical picture is subtle, the symptoms are caused by the development "mass effect" of the tumor as it propagates to the surrounding pituitary structures. Suprasellar growth leads to compression of the optic chiasm with narrowing of visual fields, infrasellar growth destructs the bottom of the sella turcica and may cause nasal cerebrospinal fluid leak, which is dangerous due depressurization of the cranial cavity and its communication with environmental pathogens, development of life-threatening conditions such as meningitis, meningoencephalitis, ventriculitis. Leading life-threatening complications of the CD are infectious and cardiovascular. But in the case of nasal liquorrhea with expansion of the tumor in sphenoid sinus with destruction of the bottom of the sella, there is an immediate threat to the life of the patient. This article presents an example of a patient with morbid obesity and lack of specific clinical manifestations of CD, in whom the diagnosis of disease CD was made on the results of laboratory and instrumental examination, which experienced a spontaneous nasal cerebrospinal fluid leak.

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Skull base cerebrospinal fluid fistula: a novel detection method based on two‐dimensional electrophoresis

Cited by 9 publications

References 20 publications

Pneumocephalus secondary to removal of an osteoma from the paranasal sinuses of a horse

Pneumocephalus secondary to removal of an osteoma from the paranasal sinuses of a horse

CSF rhinorrhea: An overview of endoscopic repair

Cerebrospinal fluid rhinorrhea as a complication of ACTH-secreting pituitary macroadenoma in a patient with morbid obesity

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