Skull base invasive low-grade meningiomas, a distinct genetic subgroup: A microarray gene expression profile analysis

Sakuma, Jun; Fujii, Masazumi; Kishida, Yugo; Iwami, Kenichiro; Oda, Kazuhiro; Iwatate, Kensho; Ichikawa, Masahiro; Bakhit, Mudathir; Sato, Taku; Waguri, Satoshi; Watanabe, Shinya; Saito, Kiyoshi

doi:10.1101/371716

Cited by 1 publication

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“…The genomic invasiveness might be another reason; some recently published studies found that even WHO grade I meningioma could show high invasive molecular behavior-like high-grade meningiomas, if they harbor specific genetic background. The tumor can cause severe edema (which indicated disruption of the arachnoid and pia), invasion to the brain, and easy recurrence, et al (38,39). This may explain the intraoperative ICA rupture case (type I, WHO grade I, Figure 3A).…”

Section: Surgical Outcomes Of Acmsmentioning

confidence: 99%

Anterior Clinoidal Meningiomas: Meningeal Anatomical Considerations and Surgical Implications

Yan

Evins

et al. 2020

Front. Oncol.

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Surgical removal of anterior clinoidal meningiomas (ACMs) remains a challenge because of its complicated relationship with surrounding meninges, major arteries and cranial nerves. This study aims to define the meningeal structures around the anterior clinoid process (ACP) and its surgical implications. Methods: Five dry skulls and 19 cadavers were used in the anatomical study. Cadavers were prepared as transverse, coronal, and sagittal plastinated sections, and the meningeal architecture around the ACP was studied with dissecting and confocal microscopies. The database of meningiomas in one single center was retrospectively reviewed, and the patients with ACMs were collected for clinical analysis. Results: The superior, lateral, medial surfaces, and the tip of ACP were covered by different layers and types of meninges. The ACMs were classified into four main types based on the sites of origin, possible extending pathways following meningeal dura. In the retrospective cohort of 131 ACMs, the percentage of types I, IIa, IIb, III, and IV were 42.0% (55/131), 19.8% (26/131), 9.2% (12/131), 16.8% (22/131), and 12.2% (16/131), respectively. We found that types IIa and I had higher chances for achieving Simpson grade 1-2 resection (92.3 and 85.4%, respectively), followed by type III (54.5%) and type IV (31.3%), while type IIb showed little chance of Simpson grade 1-2 resection. Univariate and multivariate analyses revealed ACM classification and tumor size (<3 cm) to be independent risk factors for achieving more extensive resection. Conclusion: The meningeal architecture around the ACP may guide and determine the origin and extension of ACMs. The classification based on the meningeal architecture helps to understand surgical anatomy as well as predicting surgical outcomes.

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Section: Surgical Outcomes Of Acmsmentioning

confidence: 99%

Anterior Clinoidal Meningiomas: Meningeal Anatomical Considerations and Surgical Implications

Yan

Evins

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Skull base invasive low-grade meningiomas, a distinct genetic subgroup: A microarray gene expression profile analysis

Abstract: Introduction: Meningioma is the most common adult primary brain tumor originating from

Cited by 1 publication

References 50 publications

Anterior Clinoidal Meningiomas: Meningeal Anatomical Considerations and Surgical Implications

Anterior Clinoidal Meningiomas: Meningeal Anatomical Considerations and Surgical Implications

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