Skull base metastasis from papillary thyroid carcinoma: a report of three cases

Tunio, Mutahir A.; Asiri, Mushabbab Al; Al‐Qahtani, Khalid; Aldandan, Sadiq; Riaz, Khalid; Bayoumi, Yasser

doi:10.2147/imcrj.s82792

Cited by 11 publications

(9 citation statements)

References 14 publications

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“…Skull base metastasis from DTC is a rare manifestation with only 28 reported cases, including 18 cases from follicular thyroid carcinoma (FTC) and 10 cases from PTC [18] Diagnosis in the presence of silent primary sites is challenging, because these lesions are often mistaken for primary tumours like meningioma, or schwannoma on CT and magnetic resonance imaging. [19] Histopathology along with immunohistochemical examination is crucial in diagnosing metastasis from DTC. In routine practice, thyroglobulin (TGB) and thyroid transcription factor-1 (TTF1) are the most commonly used immunomarkers to identify thyroid tumors in the setting of metastasis.…”

Section: Discussionmentioning

confidence: 99%

Papillary thyroid carcinoma presenting as metastases at unexpected sites: Report of two cases

Thomas

Manuel

2020

DCC

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Papillary thyroid carcinoma (PTC) is the most common form of differentiated thyroid carcinoma (DTC). It is generally confined to the neck with or without spread to regional lymph nodes. Distant metastases is rare, if occurs, it usually involves lung and bone. Additional locations have only been sporadically reported and were identified during the course of follow-up, subsequently to a thyroid surgery. Distant metastases as the initial presentation of PTC is a rare event. We, herein, report two cases of PTC presenting initially as metastases at unusual sites and discuss the importance of meticulous histopathological and immunohistochemical examination in such situations. Our aim is to increase awareness of the unique possibility of PTC presenting as metastatic deposits at unexpected sites.

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Section: Discussionmentioning

confidence: 99%

Papillary thyroid carcinoma presenting as metastases at unexpected sites: Report of two cases

Thomas

Manuel

2020

DCC

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“…OCS due to thyroid cancer has been previously described. [7] The treatment of OCS is challenging. Complete surgical resection is often difficult because of the presence of adjacent vital structures (brainstem, cochlea, and cranial nerves), cerebrospinal fluid leak, and bleeding.…”

Section: Discussionmentioning

confidence: 99%

Occipital condyle syndrome caused by isolated bone metastases from thyroid cancer

et al. 2019

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Occipital condyle syndrome is a rare cause of pain in the head which is characterized by severe and persistent unilateral suboccipital headache with unilateral hypoglossal nerve palsy. We report an elderly female who presented with dysarthria and suboccipital headache. On further evaluation, she was found to have a solitary bone metastases from thyroid cancer. She was treated with local radiation therapy for pain relief, total thyroidectomy, and high-dose radioiodine therapy. The patient is presently free of pain with very good control of the thyroid cancer status.

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“…Thyroid papillary carcinoma gives frequent neck lymph node metastases, occasionally to lung and bones and rarely to other areas (skeletal muscles, ovaries, submandibular gland, sphenoidal sinus, pancreas, brain, adrenal glands) [11]. Previous case reports include also metastatic PTC in infratemporal fossa, pleural metastasis of thyroid carcinoma, skull base metastasis of PTC and PTC with synchronous asymptomatic esophageal squamous cell carcinoma (ESCC) manifesting as lateral cervical lymph node enlargement [12]. Cervical lymphadenopathy as a manifestation of sarcoidosis, mimicking metastatic PTC, has also been reported [13].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Papillary Carcinoma in a Branchial Cleft Cyst—A Case Report

Papadakis¹,

Ladias²,

Chimona³

et al. 2017

JCT

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Objective: Report a rare case of a thyroid papillary carcinoma situated within a branchial cleft cyst. Case presentation: A 40-year-old male was referred to our department for a lateral neck mass assessment. Physical examination revealed a solitary palpable, painless, moveable neck mass. Assessment included complete nasal, pharynx and larynx endoscopy, neck computed tomography, and fine needle aspiration biopsy. Treatment was surgical excision of the neck mass. Histopathology confirmed a branchial cleft cyst with papillary thyroid carcinoma growth at a site. A neck and thyroid ultrasound showed presence of thyroid gland nodules (one of which with micro calcifications). Thyroid fine needle aspiration biopsy performed, was high suspicious for malignancy (BETHESDA V). Patient underwent total thyroidectomy and histopathology revealed papillary thyroid carcinoma. Conclusion: Although rarely, it is possible to face an unexpected malignancy within a clinically benign neck lesion. A thorough diagnostic work-up enables early identification of aforementioned potential malignancy. A diagnostic dilemma that arises in such cases is between primary or metastatic disease and a thyroid carcinoma arising from ectopic thyroid tissue.

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Skull base metastasis from papillary thyroid carcinoma: a report of three cases

Cited by 11 publications

References 14 publications

Papillary thyroid carcinoma presenting as metastases at unexpected sites: Report of two cases

Papillary thyroid carcinoma presenting as metastases at unexpected sites: Report of two cases

Occipital condyle syndrome caused by isolated bone metastases from thyroid cancer

Thyroid Papillary Carcinoma in a Branchial Cleft Cyst—A Case Report

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