Skull base tumor model

Gragnaniello, Cristian; Nader, Remi; Doormaal, Tristan van; Kamel, Mahmoud; Voormolen, Eduard; Lasio, Giovanni; Aboud, Emad; Regli, Luca; Tulleken, C. A. F.; Al‐Mefty, Ossama

doi:10.3171/2010.3.jns09513

Cited by 36 publications

(40 citation statements)

References 16 publications

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“…Moreover, storage time of fresh tissues is short. Similarly, the majority of researchers have filled the vessels of embalmed human heads or whole bodies with aqueous solutions [9,10,11,12,14,16,17,19,20,21,23,33,34]. Unlike water, hydrophobic perfusates (e.g., PP) are more confined to vessels, and the capacity to extravasate depends on their viscosity [18,29,35].…”

Section: Discussionmentioning

confidence: 99%

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Lifelike Vascular Reperfusion of a Thiel-Embalmed Pig Model and Evaluation as a Surgical Training Tool

Willaert

Tozzi²,

Hoof³

et al. 2016

Eur Surg Res

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Background: Vascular reperfusion of Thiel cadavers can aid surgical and anatomical instruction. This study investigated whether ideal embalming circumstances provide lifelike vascular flow, enabling surgical practice and enhancing anatomical reality. Methods: Pressure-controlled pump-driven administration of blue embalming solution was assessed directly postmortem in a pig model (n = 4). Investigation of subsequent pump-driven vascular injection of red paraffinum perliquidum (PP) included assessment of flow parameters, intracorporeal distribution, anatomical alterations, and feasibility for surgical training. The microscopic distribution of PP was analyzed in pump-embalmed pig and gravity-embalmed human small intestines. Results: Embalming lasted 50-105 min, and maximum arterial pressure was 65 mm Hg. During embalming, the following consecutive alterations were observed: arterial filling, organ coloration, venous perfusion, and further tissue coloration during the next weeks. Most organs were adequately preserved. PP generated low arterial pressures (<30 mm Hg) and drained through the venous cannula. Generally, realistic reperfusion and preservation of original anatomy were observed, but leakage in the pleural, abdominal, and retroperitoneal cavities occurred, and computed tomography showed edematous spleen and liver. Reduction of arterial flow rates after venous drainage is a prerequisite to prevent anatomical deformation, allowing simulation of various surgeries. In pump-embalmed pig small intestines, PP flowed from artery to vein through the capillaries without extravasation. In contrast, arterioles were blocked in gravity-embalmed human tissues. Conclusions: In a pig model, immediate postmortem pressure-controlled pump embalming generates ideal circumstances for (micro)vascular reperfusion with PP, permitting lifelike anatomy instruction and surgical training.

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Section: Discussionmentioning

confidence: 99%

“…Many researchers have reported on the use of reperfused body parts for surgical training [9,10,11,12,13,14,15,16]. Garrett published the first report of pump-driven arterial-arterial circulations in more than 200 complete fresh cadavers [17].…”

Section: Introductionmentioning

confidence: 99%

Lifelike Vascular Reperfusion of a Thiel-Embalmed Pig Model and Evaluation as a Surgical Training Tool

Willaert

Tozzi²,

Hoof³

et al. 2016

Eur Surg Res

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“…It has a distinct Computed Tomography and Magnetic Resonance Imaging characteristics that simulates the preoperative planning of the real procedure. [32] Financial resources No war can be won without proper resources. Running a neurosurgical cadaver laboratory needs lot of capital investment right from its inception to maintenance.…”

Section: Advances In Cadaver Dissectionmentioning

confidence: 99%

Practical guidelines for setting up neurosurgery skills training cadaver laboratory in India

et al. 2014

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Though the necessity of cadaver dissection is felt by the medical fraternity, and described as early as 600 BC, in India, there are no practical guidelines available in the world literature for setting up a basic cadaver dissection laboratory for neurosurgery skills training. Hands-on dissection practice on microscopic and endoscopic procedures is essential in technologically demanding modern neurosurgery training where ethical issues, cost constraints, medico-legal pitfalls, and resident duty time restrictions have resulted in lesser opportunities to learn. Collaboration of anatomy, forensic medicine, and neurosurgery is essential for development of a workflow of cadaver procurement, preservation, storage, dissection, and disposal along with setting up the guidelines for ethical and legal concerns.

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“…Nonetheless, most of these simulation models have focused on teaching common surgical approaches. Although these models have improved our understanding of normal surgical anatomy, only a few tools are available to simulate pathological surgical environments such as dealing with tumor removal …”

Section: Introductionmentioning

confidence: 99%

Novel mouse model for simulating microsurgical tumor excision with facial nerve preservation

2015

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Skull base tumor model

Abstract: The skull base tumor model is an effective tool to provide more practice in preoperative planning and technical skills.

Cited by 36 publications

References 16 publications

Lifelike Vascular Reperfusion of a Thiel-Embalmed Pig Model and Evaluation as a Surgical Training Tool

Lifelike Vascular Reperfusion of a Thiel-Embalmed Pig Model and Evaluation as a Surgical Training Tool

Practical guidelines for setting up neurosurgery skills training cadaver laboratory in India

Novel mouse model for simulating microsurgical tumor excision with facial nerve preservation

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