Skull Metastases From Follicular Thyroid Carcinoma

Kearns, David R.; Robinson, Lee D.; Wright, Geoffrey L.; Wickersham, Jean K.; Parke, Robert B

doi:10.1001/archotol.1988.01860160098030

Cited by 20 publications

(14 citation statements)

References 5 publications

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“…24) The metastatic lesion is usually hypervascular and osteolytic on radiological examination. 14) Bleeding is often profuse during surgical resection. 26) The most common symptom of skull base metastasis from FTC is cranial nerve dysfunction, which was observed in 17 of the 19 cases.…”

Section: Discussionmentioning

confidence: 99%

“…The lung is the most common metastatic site for thyroid carcinoma followed by the bone, 7,10,26,27) but skull metastasis of thyroid carcinoma is rare, with few reported cases. [1][2][3][4][5][6][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]25,26,[28][29][30][31][32][33][34][35][36][37][38]40,41,44,45) The largest series of skull metastasis from thyroid carcinoma reported a frequency of only 2.5% among 473 patients. 26) Moreover, skull base metastasis from differentiated thyroid carcinoma is even rarer, with only 23 reported cases, including 17 cases of skull base metastasis from FTC that involved the clivus, cavernous sinus, sella turcica, petrous apex, and petrous ridge.…”

Section: Introductionmentioning

confidence: 99%

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Skull Base Metastasis From Follicular Thyroid Carcinoma -Two Case Reports-

Matsuno

Katakami

Okazaki

et al. 2010

Neurol. Med. Chir.(Tokyo)

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A 58-year-old woman and a 71-year-old woman presented with extremely rare skull base metastases from follicular thyroid carcinoma (FTC). Surgical removal and external radiotherapy were performed followed by iodine-131 ( 131 I) brachytherapy and thyroid hormone administration. The metastatic tumors in the skull base were well controlled. Treatment for skull base metastasis from FTC includes surgical debulking of the metastatic lesion, as well as complete resection of the thyroid gland, followed by internal irradiation with 131 I, external irradiation, and administration of thyroid hormone to prevent tumor growth by suppression of endogenous thyroid-stimulating hormone. Skull base metastases may be the initial clinical presentation of FTC, with silent primary sites. The possibility of skull base metastasis from FTC should be considered in patients with clinical symptoms of cranial nerve dysfunction and radiological findings of bone destruction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Skull Base Metastasis From Follicular Thyroid Carcinoma -Two Case Reports-

Matsuno

Katakami

Okazaki

et al. 2010

Neurol. Med. Chir.(Tokyo)

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“…15,24,26 Prior studies have assessed the prognostic factors associated with systemic metastasis from thyroid carcinoma; however, none have specifically investigated the factors that affect survival in patients undergoing surgery for spinal metastases. 3,5,13,16,18,21,25,32,36,39,40 Therefore, the objective of this study was to analyze a series of consecutive patients who underwent surgery for spinal metastasis from thyroid cancer in order to identify factors associated with postoperative survival and complications. This prognostic information may aid in clinical decision making, as patients with a more favorable prognosis may warrant more aggressive intervention and patients with poor life expectancy may be spared from aggressive surgery.…”

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confidence: 99%

Factors affecting survival in 43 consecutive patients after surgery for spinal metastases from thyroid carcinoma

Sellin

Suki

Harsh

et al. 2015

SPI

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OBJECT Spinal metastases account for the majority of bone metastases from thyroid cancer. The objective of the current study was to analyze a series of consecutive patients undergoing spinal surgery for thyroid cancer metastases in order to identify factors that influence overall survival. METHODS The authors retrospectively reviewed the records of all patients who underwent surgery for spinal metastases from thyroid cancer between 1993 and 2010 at the University of Texas MD Anderson Cancer Center. RESULTS Forty-three patients met the study criteria. Median overall survival was 15.4 months (95% CI 2.8–27.9 months) based on the Kaplan-Meier method. The median follow-up duration for the 4 patients who were alive at the end of the study was 39.4 months (range 1.7–62.6 months). On the multivariate Cox analysis, progressive systemic disease at spine surgery and postoperative complications were associated with worse overall survival (HR 8.98 [95% CI 3.46–23.30], p < 0.001; and HR 2.86 [95% CI 1.30–6.31], p = 0.009, respectively). Additionally, preoperative neurological deficit was significantly associated with worse overall survival on the multivariate analysis (HR 3.01 [95% CI 1.34–6.79], p = 0.008). Conversely, preoperative embolization was significantly associated with improved overall survival on the multivariate analysis (HR 0.43 [95% CI 0.20–0.94], p = 0.04). Preoperative embolization and longer posterior construct length were significantly associated with fewer and greater complications, respectively, on the univariate analysis (OR 0.24 [95% CI 0.06–0.93] p = 0.04; and OR 1.24 [95% CI 1.02–1.52], p = 0.03), but not the multivariate analysis. CONCLUSIONS Progressive systemic disease, postoperative complications, and preoperative neurological deficits were significantly associated with worse overall survival, while preoperative spinal embolization was associated with improved overall survival. These factors should be taken into consideration when considering such patients for surgery. Preoperative embolization and posterior construct length significantly influenced the incidence of postoperative complications only on the univariate analysis.

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“…The metastatic mass may invade the epidural space but the dura forms a barrier to further intracranial spread [9]. Most of these tumours are located in the posterior portion of the cranium and fed primarily from the external carotid artery system [8][9][10][11] [15]. Gates suggested that the apparent predilection for the scalp could be due to the vascularity and relative immobility of the skin at this site [16].…”

Section: Discussionmentioning

confidence: 99%

Scalp, Skull, Lung and Bone Metastasis from Follicular Thyroid Carcinoma - A Rare Case Report

Gupta¹,

Madholia²,

Mukherjee³

et al. 2017

Journal of Cancer science and Clinical Oncology

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Concurrent scalp, skull, lung and bone metastasis from follicular thyroid carcinoma is a very rare event. We herein present the case of a 37-year's old lady, who presented to us with huge scalp swelling that proved to be metastasis from a follicular thyroid carcinoma. The metastatic workup disclosed bilateral lung metastasis and additional metastasis in right iliac crest and 6th rib. The course of her disease was relentless. Although follicular thyroid carcinoma has an excellent prognosis, the presence of metastatic disease leads to a very dismal prognosis.

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Skull Metastases From Follicular Thyroid Carcinoma

Cited by 20 publications

References 5 publications

Skull Base Metastasis From Follicular Thyroid Carcinoma -Two Case Reports-

Skull Base Metastasis From Follicular Thyroid Carcinoma -Two Case Reports-

Factors affecting survival in 43 consecutive patients after surgery for spinal metastases from thyroid carcinoma

Scalp, Skull, Lung and Bone Metastasis from Follicular Thyroid Carcinoma - A Rare Case Report

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