Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature

Rizzo, Alessandro; Nigro, Maria Concetta; Ramponi, Vania; Gallo, Carmine; Perrone, Anna Myriam; Iaco, Pierandrea De; Frezza, G.P.; Balestrini, Damiano; Benedetto, Maika di; Morbiducci, Jarno; Pantaleo, Maria Abbondanza; Nannini, Margherita

doi:10.3389/fonc.2020.00869

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…Head and neck leiomyosarcomas account for 1% to 4% of all leiomyosarcomas [9,10]. Primary intracranial-extracranial communicating leiomyosarcomas are exceedingly rare, frequently originating from the meningeal interstitium and unrelated to meningeal epithelial cells [11]. These tumors can occur at any age, with no signi cant gender difference, and are typically seen in individuals with compromised immune function [12], especially in patients positive for HIV carrying the EB virus [13].…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of primary intracranial and extracranial communicating leiomyosarcoma: a case report

Pu,

Wang,

et al. 2024

Preprint

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Background: Primary intracranial-extracranial communicating leiomyosarcomas, capable of invading both the intracranial and extracranial regions and involving complex anatomical structures, are exceedingly rare neoplasms. Case presentation: A 37-year-old male patient who initially presented with a subcutaneous mass on the left frontal vertex. Following surgical intervention, a recurrent lump appeared on the left frontotemporal vertex. Symptoms, computed tomography (CT), and magnetic resonance imaging (MRI) revealed a lump on the left frontal vertex accompanied by an irregular abnormal lesion. On both occasions, the diagnosis of leiomyosarcoma was confirmed. The patient underwent leiomyosarcoma excision under general anesthesia. Recurrence of the leiomyosarcoma occurred 2 years and 4 months post-surgery, necessitating an expanded excision of the lesion. After 2 years of follow-up, no significant complications were observed, and the patient's condition remains stable. Conclusion: Primary extracranial communicating leiomyosarcoma is an exceptionally rare entity, with surgery currently serving as the primary treatment modality. The decision to excise the lesion should be based on the patient’s age, tumor location, pathological features, and the presence of distant metastases.

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Section: Discussionmentioning

confidence: 99%

Surgical treatment of primary intracranial and extracranial communicating leiomyosarcoma: a case report

Pu,

Wang,

et al. 2024

Preprint

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“…So far, only six cases of skull and dural metastasis from primary uLMS without involvement of the brain parenchyma have been reported. [2][3][4][5] However, to the best of our knowledge, there has never been any published case of SDH caused by skull and dural metastasis from a primary uLMS. uLMS disseminates early through hematogenous spread for distant sites of metastasis such as the lungs and liver.…”

Section: Discussionmentioning

confidence: 99%

Chronic Subdural Hematoma Caused by Calvarial and Dural Metastasis from Uterine Leiomyosarcoma

Soo

Teo

Mohamad

et al. 2022

JNRP

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Uterine Leiomyosarcoma (uLMS) is an aggressive tumor with poor clinical outcome. Skull and dural metastasis from uterine uLMS is exceptionally rare. We report a 60-year-old woman who had a 6 months' history of per vaginal bleed and abdominal pain who presented to us in a confused state and raised intracranial pressure symptoms with swelling over her right frontal-temporal region. She underwent excision of the right frontal-temporal tumor and evacuation of a right subdural hematoma (SDH), which greatly improved her condition. Postoperatively, she underwent adjuvant radiotherapy and chemotherapy. This case highlights the importance of clinical suspicion to diagnose patients with this rare metastasis to this region and the appropriate subsequent treatment. We herein report a rare case of metastatic uLMS with skull and dural metastasis that presented with SDH.

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“…Primary intracranial-extracranial communication leiomyosarcoma is very rare, mostly derived from meningeal mesenchyme, and has nothing to do with meningeal epithelial cells, it is a new type of tumor [8]. At present, there are no clear diagnostic criteria for it in clinical practice, and the diagnosis is mostly based on the imaging ndings and pathological immunohistochemistry of the tumor.…”

Section: Imaging and Pathological Featuresmentioning

confidence: 99%

Surgical Treatment of Primary Intracranial and Extracranial Communicating Leiomyosarcoma with One Case Recurred

wang

Zhang

et al. 2021

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backgroundTo analyze and summarize the clinical features and diagnosis and treatment experience on primary intracranial and extracranial communicating leiomyosarcoma to deepen clinicians’understanding of the rare disease.Cases presentationThe clinical data and recurrence of a patient who was diagnosed with primary intracranial and extracranial communicating leiomyosarcoma admitted to the Neurosurgery Department, The Affiliated Ganmei Hospital of Kunming Medical University in May 2015 were retrospectively analyzed. According to the patient data, two successful surgical operations were performed and the surgeries went well, with more than 2-year and 8-month follow-up so far. No obvious complications were found after hospital discharge, and follow-up was continued.ConclusionsSurgical removal is the most important and effective treatment means for primary intracranial and extracranial communicating leiomyosarcoma currently.

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Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature

Cited by 7 publications

References 19 publications

Surgical treatment of primary intracranial and extracranial communicating leiomyosarcoma: a case report

Surgical treatment of primary intracranial and extracranial communicating leiomyosarcoma: a case report

Chronic Subdural Hematoma Caused by Calvarial and Dural Metastasis from Uterine Leiomyosarcoma

Surgical Treatment of Primary Intracranial and Extracranial Communicating Leiomyosarcoma with One Case Recurred

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