2023
DOI: 10.1101/2023.01.18.524597
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sLASER and PRESS Perform Similarly at Revealing Metabolite-Age Correlations

Abstract: Purpose To compare the respective ability of PRESS and sLASER to reveal biological relationships, using age as a validation covariate. Methods MRS data were acquired from 102 healthy volunteers using PRESS and sLASER in centrum semiovale (CSO) and posterior cingulate cortex (PCC) regions. Acquisition parameters included TR/TE 2000/30 ms; 96 transients; 2048 datapoints sampled at 2 kHz. Spectra were analyzed using Osprey. Signal-to-noise ratio (SNR), full-width-half-maximum linewidth of tCr, and metabolite conc… Show more

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