Slaughterhouse report of intrahepatic cholangiocarcinoma in a Holstein cow

Azizi, Shahrzad; Kheirandiah, Reza; Sami, Masoud

doi:10.1007/s00580-016-2324-z

Cited by 2 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the cholangiocarcinomas of the current study, only the multinodular pattern was observed, similar to other cases with the same gross pattern in hepatocellular carcinomas (Ohfuji 2012, Azizi et al 2016. In PHN, it is unclear whether multiple nodules arise from intrahepatic vascular metastases or multiple origins in different foci (Wettimuny 1969, Barros 2016.…”

Section: Discussionsupporting

confidence: 79%

Primary hepatic neoplasms in cattle

et al. 2020

View full text Add to dashboard Cite

Primary hepatic neoplasms are mostly detected in cattle as incidental findings in slaughterhouses or diagnosed at the necropsy, wherein it may be related to the cause of death. A proper characterization of primary hepatic neoplasms is essential to provide an accurate diagnosis, especially at the slaughter lines, in order to reduce erroneous condemnations. This work aimed to characterize the gross, histological, and immunohistochemical features of primary liver neoplasms detected in slaughtered cattle in Southern Brazil. Nineteen primary hepatic neoplasms were identified. Grossly, these lesions were classified according to their distribution, as focal, multifocal, or diffuse. Histologically, the shape and arrangement of the cells, as well as possible malignant features were evaluated. Immunohistochemistry (IHC) was also performed for biliary epithelium (anti-CK7) and hepatocytes (anti-Hep Par-1) markers. Hepatocellular carcinoma (84.2%) was the most frequently detected hepatic neoplasm, followed by cholangiocarcinoma (15.8%), and these were only identified in adult cows. Hepatocellular carcinomas occurred as solitary masses or multifocal nodules, which on the cut surface were often green. Cholangiocarcinomas occurred as multifocal nodules, occasionally showing an umbilicated appearance. Histologically, hepatocellular carcinomas had mostly trabecular and solid patterns, while cholangiocarcinomas presented mostly a solid arrangement. Upon IHC, all hepatocellular carcinomas were immunolabeled for anti-Hep Par-1, ranging from mild (25%), moderate (31.2%) to marked (43.7%), while immunolabeling for anti-CK7 was detected only in one case of cholangiocarcinoma.

show abstract

Section: Discussionsupporting

confidence: 79%

Primary hepatic neoplasms in cattle

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Primary hepatic neoplasms are rarely described in cattle. 1,2,[4][5][6]11,19 Although most cases occur as incidental findings in the slaughterhouse, 1,3,6,10 tumors can occasionally lead to clinical signs associated with hepatic failure. 11,19 The clinical signs in our case were nonspecific but likely associated with the presence of tumors in the liver and other abdominal organs.…”

mentioning

confidence: 99%

Metastatic cholangiocarcinoma mimicking tuberculosis in a cow

2021

View full text Add to dashboard Cite

Here we describe a metastatic hepatic cholangiocarcinoma (cholangiocellular carcinoma) in a 14-y-old Beefmaster cow that was euthanized because of depression and progressive weight loss. Gross changes included coalescing, white-to-yellow, firm-to-hard nodules with central areas of necrosis and mineralization that effaced much of the hepatic parenchyma, omentum, mesentery, ruminal serosa, and diaphragm. A fresh sample of a hepatic nodule was submitted for a modified acid-fast (MAF) stain during autopsy to rule out tuberculosis. The MAF stain was inconclusive, and the sample was subsequently submitted for a PCR assay for Mycobacterium spp. Histologically, all nodules consisted of a neoplastic proliferation of epithelial cells surrounded by extensive areas of desmoplasia, consistent with a metastatic cholangiocarcinoma. PCR for Mycobacterium spp. was negative. Although the histologic diagnosis in our case was metastatic hepatic cholangiocarcinoma, gross changes were strikingly similar to those described in cases of tuberculosis, highlighting the need to remain vigilant in the identification of zoonotic and suspected foreign animal diseases during autopsy to protect human health.

show abstract

Slaughterhouse report of intrahepatic cholangiocarcinoma in a Holstein cow

Cited by 2 publications

References 25 publications

Primary hepatic neoplasms in cattle

Primary hepatic neoplasms in cattle

Metastatic cholangiocarcinoma mimicking tuberculosis in a cow

Contact Info

Product

Resources

About