SLC16A1-AS1 enhances radiosensitivity and represses cell proliferation and invasion by regulating the miR-301b-3p/CHD5 axis in hepatocellular carcinoma

Pei, Shenglin; Chen, Zuyi; Tan, Huajun; Fan, Liwei; Zhang, Baina; Zhao, Chang

doi:10.1007/s11356-020-09998-1

Cited by 22 publications

(17 citation statements)

References 59 publications

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“…LNC00242 was high-expressed in gastric cancer (GC) tissue regulated by LINC00242/miR-1-3p/G6PD axis (Deng et al, 2021), and it may be a promising biomarker of GC (Zhong et al, 2020). Mediated by E2F1, SLC16A1-AS1 could progress bladder cancer to the invasive stage (Logotheti et al, 2020) and serve as a new diagnostic indicator in hepatocellular carcinoma (Song et al, 2019;Pei et al, 2020). It has been reported that SLC25A5-AS1 functions as a suppressor in the progression of gastric cancer to regulate cellular behaviors via the miR-19a-3p/PTEN/PI3K/AKT signaling pathway (Li et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Ferroptosis-Related IncRNAs Are Prognostic Biomarker of Overall Survival in Pancreatic Cancer Patients

Chen

Gao

Zang

et al. 2022

Front. Cell Dev. Biol.

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Pancreatic cancer (PC) is one of the most lethal malignancies, the mortality and morbidity of which have been increasing over the past decade. Ferroptosis, a newly identified iron-dependent cell death pattern, can be induced by iron chelators and small lipophilic antioxidants. Nonetheless, the prognostic significance of ferroptosis-related lncRNAs in PC remains to be clarified. We obtained the lncRNA expression matrix and clinicopathological information of PC patients from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) datasets in the current study. Firstly, we conducted Pearson correlation analysis to delve into the ferroptosis-related lncRNAs, and univariate Cox analysis was implemented to examine the prognostic values in PC patients. Twenty-three prognostic ferroptosis-related lncRNAs were confirmed and loaded into the least absolute shrinkage and selection operator Cox (LASSO-Cox) analysis, then a ferroptosis-related lncRNA prognostic marker (Fe-LPM) was established in the TCGA dataset. Risk scores of patients were calculated and segregated PC patients into low-risk and high-risk subgroups in each dataset. The prognostic capability of Fe-LPM was also confirmed in the ICGC dataset. Gene set enrichment analysis (GSEA) revealed that several ferroptosis-related pathways were enriched in low-risk subgroups. Furthermore, we adopted a multivariate Cox regression to establish a nomogram based on risk score, age, pathological T stage and primary therapy outcome. A competing endogenous RNA (ceRNA) network was also created relied on four of the twenty-three ferroptosis-related lncRNAs. In conclusion, the eight Fe-LPM can be utilized to anticipate the overall survival (OS) of PC patients, which are meaningful to guiding clinical strategies in PC.

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Section: Discussionmentioning

confidence: 99%

Ferroptosis-Related IncRNAs Are Prognostic Biomarker of Overall Survival in Pancreatic Cancer Patients

Chen

Gao

Zang

et al. 2022

Front. Cell Dev. Biol.

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“…LNC00242 was high-expressed in gastric cancer (GC) tissue regulated by LINC00242/miR-1-3p/G6PD axis [21], it may be a promising biomarker of GC [22]. Mediated by E2F1, SLC16A1-AS1 could progress bladder cancer to invasive stage [23], and sever as a new diagnostic indicator in hepatocellular carcinoma [24,25]. It has been reported that SLC25A5-AS1 functions as a suppressor in the progression of gastric cancer to regulate cellular behaviors via miR-19a-3p/PTEN/PI3K/AKT signaling pathway [26].…”

Section: Discussionmentioning

confidence: 99%

Ferroptosis-Related IncRNAs Are Prognostic Biomarker of Overall Survival in Pancreatic Cancer Patients

Chen¹,

Gao²,

Zang³

et al. 2021

Preprint

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Background: Pancreatic cancer (PC) is one of the most lethal malignancies, the mortality and morbidity of which have been increasing over the past decade. Ferroptosis, a newly identified iron-dependent pattern of cell death, can be induced by iron chelators and small lipophilic antioxidants. Nonetheless, the prognostic significance of ferroptosis-related lncRNAs in PC remains to be explicated. Methods: We obtained the lncRNA expression matrix and clinicopathological information of PC patients from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) datasets in the current study. Pearson correlation analysis was conducted to delve into the ferroptosis-related lncRNAs, and univariate Cox analysis was implemented to examine the prognostic values in PC patients. The least absolute shrinkage and selection operator Cox (LASSO-Cox) analysis was performed to establish a ferroptosis-related lncRNA prognostic marker (Fe-LPM). Furthermore, we adopted a multivariate Cox regression to establish a nomogram. Gene set enrichment analysis (GSEA) and a competing endogenous RNA (ceRNA) network were also created.Results: The eight Fe-LPM (including SLC16A1-AS1, SETBP1-DT, ZNF93-AS1, SLC25A5-AS1, AC073896.2, LINC00242, PXN-AS1 and AC036176) was confirmed, and displayed a sturdy prognostic capability in the training and validation dataset. We established a nomogram based on risk score, age, pathological T stage and primary therapy outcome. GSEA revealed that several ferroptosis-related pathways are enriched in low-risk subgroups. A ceRNA network (including 4 lncRNAs, 27 miRNAs and 57 mRNAs) was also constructed to provide us some clues for finding the potential functions of these ferroptosis-related lncRNAs in PC.Conclusion: The eight Fe-LPM can be utilized for anticipating the overall survival (OS) of PC patients, which are meaningful to guiding clinical strategies of PC.

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“…Hence, it is important to understand and correlate the expression of MCTs and ECMs in different compartments. Our analysis revealed nine differentially expressed MCT genes in both stromal and epithelial samples, including the upregulated thyroid hormone (TH) transporters MCT8 ( SLC16A12 ) and MCT10 ( SLC16A10 ), monocarboxylate transporter MCT2 ( SLC16A7 ), MCT6 ( SLC16A5 ) with a potential role in glucose and lipid metabolism, and an lncRNA SLC16A1-AS1 previously identified as a prognostic or diagnostic biomarker in a number of cancers [ 20 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. To our knowledge, the upregulation of the TH transporters in the stromal–epithelial samples has not been highlighted previously.…”

Section: Discussionmentioning

confidence: 99%

Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma

Ufuk

Garner

Stevens

et al. 2022

Cancers

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Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a five-year survival rate of <8%. PDAC is characterised by desmoplasia with an abundant extracellular matrix (ECM) rendering current therapies ineffective. Monocarboxylate transporters (MCTs) are key regulators of cellular metabolism and are upregulated in different cancers; however, their role in PDAC desmoplasia is little understood. Here, we investigated MCT and ECM gene expression in primary PDAC patient biopsies using RNA-sequencing data obtained from Gene Expression Omnibus. We generated a hypernetwork model from these data to investigate whether a causal relationship exists between MCTs and ECMs. Our analysis of stromal and epithelial tissues (n = 189) revealed nine differentially expressed MCTs, including the upregulation of SLC16A2/6/10 and the non-coding SLC16A1-AS1, and 502 ECMs, including collagens, laminins, and ECM remodelling enzymes (false discovery rate < 0.05). A causal hypernetwork analysis demonstrated a bidirectional relationship between MCTs and ECMs; four MCT and 255 ECM-related transcripts correlated with 90% of the differentially expressed ECMs (n = 376) and MCTs (n = 7), respectively. The hypernetwork model was robust, established by iterated sampling, direct path analysis, validation by an independent dataset, and random forests. This transcriptomic analysis highlights the role of MCTs in PDAC desmoplasia via associations with ECMs, opening novel treatment pathways to improve patient survival.

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SLC16A1-AS1 enhances radiosensitivity and represses cell proliferation and invasion by regulating the miR-301b-3p/CHD5 axis in hepatocellular carcinoma

Cited by 22 publications

References 59 publications

Ferroptosis-Related IncRNAs Are Prognostic Biomarker of Overall Survival in Pancreatic Cancer Patients

Ferroptosis-Related IncRNAs Are Prognostic Biomarker of Overall Survival in Pancreatic Cancer Patients

Ferroptosis-Related IncRNAs Are Prognostic Biomarker of Overall Survival in Pancreatic Cancer Patients

Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma

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