SLC26A7 protein is a chloride/bicarbonate exchanger and its abundance is osmolarity- and pH-dependent in renal epithelial cells

Ullah, A.K.M. Shahid; Rumley, Alina C.; Peleh, Valentina; Fernandes, Daphne J.; Almomani, Ensaf Y.; Berrini, Mattia; Lashhab, Rawad; Touret, Nicolas; Alexander, R. Todd; Herrmann, Johannes M.; Cordat, Emmanuelle

doi:10.1016/j.bbamem.2020.183238

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…Slc26a7 knockout mice exhibit metabolic acidosis and excrete a more alkaline urine than their wild-type counterparts at baseline [ 127 ]. In transfected MDCK, the SLC26A7 abundance increases with medium osmolarity and decreases with extracellular acidic pH [ 108 ]. Both AE1 and SLC26A7 could be involved in HCO 3 − reabsorption by type A IC and in the regulation of H + secreting cells in response to modulations in extracellular pH and osmolarity [ 108 ].…”

Section: Fine-tuning Of Acid Excretion In the Distal Nephron And The ...mentioning

confidence: 99%

“…In transfected MDCK, the SLC26A7 abundance increases with medium osmolarity and decreases with extracellular acidic pH [ 108 ]. Both AE1 and SLC26A7 could be involved in HCO 3 − reabsorption by type A IC and in the regulation of H + secreting cells in response to modulations in extracellular pH and osmolarity [ 108 ]. Their cooperation has not yet been directly demonstrated.…”

Section: Fine-tuning Of Acid Excretion In the Distal Nephron And The ...mentioning

confidence: 99%

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State of knowledge on ammonia handling by the kidney

Bourgeois,

Houillier

2024

Pflugers Arch - Eur J Physiol

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The disposal of ammonia, the main proton buffer in the urine, is important for acid–base homeostasis. Renal ammonia excretion is the predominant contributor to renal net acid excretion, both under basal condition and in response to acidosis. New insights into the mechanisms of renal ammonia production and transport have been gained in the past decades. Ammonia is the only urinary solute known to be produced in the kidney and selectively transported through the different parts of the nephron. Both molecular forms of total ammonia, NH3 and NH4+, are transported by specific proteins. Proximal tubular ammoniagenesis and the activity of these transport processes determine the eventual fate of total ammonia produced and excreted by the kidney. In this review, we summarized the state of the art of ammonia handling by the kidney and highlighted the newest processes described in the last decade.

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Section: Fine-tuning Of Acid Excretion In the Distal Nephron And The ...mentioning

confidence: 99%

Section: Fine-tuning Of Acid Excretion In the Distal Nephron And The ...mentioning

confidence: 99%

State of knowledge on ammonia handling by the kidney

Bourgeois,

Houillier

2024

Pflugers Arch - Eur J Physiol

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“…Similarly, deletion of Slc26a7 induces distal renal tubular acidosis in mice [114]. Overexpression of Slc26a7 increases pH in Madin-Darby canine kidney (MDCK) cells, and acidification of the culture media decreases Slc26a7 expression in MDCK cells [133].…”

Section: Slc26a6mentioning

confidence: 99%

Chloride/Multiple Anion Exchanger SLC26A Family: Systemic Roles of SLC26A4 in Various Organs

Lee,

Hong

2024

IJMS

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Solute carrier family 26 member 4 (SLC26A4) is a member of the SLC26A transporter family and is expressed in various tissues, including the airway epithelium, kidney, thyroid, and tumors. It transports various ions, including bicarbonate, chloride, iodine, and oxalate. As a multiple-ion transporter, SLC26A4 is involved in the maintenance of hearing function, renal function, blood pressure, and hormone and pH regulation. In this review, we have summarized the various functions of SLC26A4 in multiple tissues and organs. Moreover, the relationships between SLC26A4 and other channels, such as cystic fibrosis transmembrane conductance regulator, epithelial sodium channel, and sodium chloride cotransporter, are highlighted. Although the modulation of SLC26A4 is critical for recovery from malfunctions of various organs, development of specific inducers or agonists of SLC26A4 remains challenging. This review contributes to providing a better understanding of the role of SLC26A4 and development of therapeutic approaches for the SLC26A4-associated hearing loss and SLC26A4-related dysfunction of various organs.

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“…In particular, a different transporter function may be present for the same transporter when it resides in different cell types. The Cordat lab determined that the SLC26A7 protein is a chloride/bicarbonate exchanger in kidney cells, which is in contrast to its role as a chloride channel in oocytes [ 17 ]. Furthermore, they show that the abundance of this protein at the cell surface is dependent on the osmolarity of the cell culture medium, and pH of the cells.…”

mentioning

confidence: 99%

Structure and function of proteins in membranes and nanodiscs

Lemieux

Overduin

2021

Biochimica et Biophysica Acta (BBA) - Biomembranes

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The field of membrane structural biology represents a fast-moving field with exciting developments including native nanodiscs that allow preparation of complexes of post-translationally modified proteins bound to biological lipids. This has led to conceptual advances including biological membrane:protein assemblies or “memteins” as the fundamental functional units of biological membranes. Tools including cryo-electron microscopy and X-ray crystallography are maturing such that it is becoming increasingly feasible to solve structures of large, multicomponent complexes, while complementary methods including nuclear magnetic resonance spectroscopy yield unique insights into interactions and dynamics. Challenges remain, including elucidating exactly how lipids and ligands are recognized at atomic resolution and transduce signals across asymmetric bilayers. In this special volume some of the latest thinking and methods are gathered through the analysis of a range of transmembrane targets. Ongoing work on areas including polymer design, protein labelling and microfluidic technologies will ensure continued progress on improving resolution and throughput, providing deeper understanding of this most important group of targets.

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SLC26A7 protein is a chloride/bicarbonate exchanger and its abundance is osmolarity- and pH-dependent in renal epithelial cells

Cited by 4 publications

References 41 publications

State of knowledge on ammonia handling by the kidney

State of knowledge on ammonia handling by the kidney

Chloride/Multiple Anion Exchanger SLC26A Family: Systemic Roles of SLC26A4 in Various Organs

Structure and function of proteins in membranes and nanodiscs

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