SLC30A7 has anti-oxidant stress effects in high glucose-induced apoptosis via the NFE2L2/HMOX1 signal transduction pathway

Zhang, Xiuli; Guan, Tingwen; Yang, Boxuan; Chen, Zhihong; Wan, Qijun; Gu, Harvest F.

doi:10.1016/j.diabres.2020.108445

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…ARRDC3 is associated with inflammation, cellular invasion, etc., which promotes H. pylori-associated gastritis by regulating protease-activated receptor 1 and inhibits invasive metastasis of breast cancer cells by regulating G protein-coupled receptor lysosomes [ 29 ]. HMOX1 could regulate the proliferation and apoptosis of human cardiomyocytes and play an anti-oxidative stress role in apoptosis induced by high glucose [ 30 , 31 ]. BRD4 inhibition prevented diabetic cardiomyopathy induced by high-fat diet through activating mediated mitochondrial autophagy [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Ferroptosis-related potential biomarkers and immunocyte characteristics in Chronic Thromboembolic Pulmonary Hypertension via bioinformatics analysis

Lin,

Zhang

et al. 2023

BMC Cardiovasc Disord

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Background Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a form of pulmonary hypertension with a high mortality rate. A new type of iron-mediated cell death is Ferroptosis, which is characterized by the accumulation of lethal iron ions and lipid peroxidation leading to mitochondrial atrophy and increased mitochondrial membrane density. Now, there is a lack of Ferroptosis-related biomarkers (FRBs) associated with pathogenic process of CTEPH. Methods The differentially expressed genes (DEGs) of CTEPH were obtained by GEO2R. Genes related to Ferroptosis were obtained from FerrDb database. The intersection of Ferroptosis and DEGs results in FRBs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed in Database for Annotation, Visualization and Integrated Discovery (DAVID) database. The optimal potential biomarkers for CTEPH were analyzed by least absolute shrinkage and selection operator (LASSO) and support vector machine-recursive feature elimination (SVM-RFE) machine learning. The four hub genes were verified from the Gene Expression Omnibus (GEO) dataset GSE188938. Immune infiltration was analyzed by CIBERSORT. SPSS software was used to analyze the Spearman rank correlation between FRBs identified and infiltration-related immune cells, and p < 0.05 was considered as statistically significant. Results In this study, potential genetic biomarkers associated with Ferroptosis in CTEPH were investigated and explored their role in immune infiltration. In total, we identified 17 differentially expressed Ferroptosis-associated genes by GEOquery package. The key FRBs including ARRDC3, HMOX1, BRD4, and YWHAE were screened using Lasso and SVM-RFE machine learning methods.Through gene set GSE188938 verification, only upregulation of gene ARRDC3 showed statistical difference. In addition, immune infiltration analysis using the CIBERSORT algorithm revealed the infiltration of Eosinophils and Neutrophils in CTEPH samples was less than that in the control group. And correlation analysis revealed that ARRDC3 was positively correlated with T cells follicular helper (r = 0.554, p = 0.017) and negatively correlated with Neutrophils (r = -0.47, p = 0.049). Conclusions In conclusion, ARRDC3 upregulation with different immune cell infiltration were involved in the development of CTEPH. ARRDC3 might a potential Ferroptosis-related biomarker for CTEPH treatment. This study provided a new insight into pathogenesis CTEPH.

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Section: Discussionmentioning

confidence: 99%

Identification of Ferroptosis-related potential biomarkers and immunocyte characteristics in Chronic Thromboembolic Pulmonary Hypertension via bioinformatics analysis

Lin,

Zhang

et al. 2023

BMC Cardiovasc Disord

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“…Heme oxygenase-1 (HMOX1), as a target gene of NFE2L2, plays an important role in antioxidant resistance [ 74 , 75 ]. The 7th member of SLC30 family (SLC30A7) exerts antioxidant effects in high-glucose-induced cells through the NFE2L2/HMOX1 signaling pathway [ 76 ]. High levels of glucose and increased ROS production over-activate sodium/glucose co-transporter type 2 (SGLT2) transporters in tubular cells, which in turn can exacerbate oxidative stress.…”

Section: Oxidative Stress In Diabetic Kidney Diseasementioning

confidence: 99%

Effects of antioxidants on diabetic kidney diseases: mechanistic interpretations and clinical assessment

et al. 2023

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Diabetic kidney disease (DKD) is more prevalent with an increase in diabetes mellitus. Oxidative stress is a major factor in the occurrence and progression of DKD. Defending against oxidative stress and restoring antioxidant defense might be key to preventing and treating DKD. The purpose of this article is to provide an explanation of how oxidative stress affects DKD, conduct a systematic review and meta-analysis on DKD, and examine the effect of antioxidants on the disease. An analysis of 19 randomized controlled trials showed that the use of antioxidants could reduce UAE (albumin excretion rate) in patients with DKD (SMD: − 0.31; 95% CI [− 0.47, − 0.14], I2 = 0%), UACR (urine albumin/creatinine ratio) (SMD: − 0.60; 95% CI [− 1.15, − 0.06], I2 = 89%), glycosylated hemoglobin (hbA1c) (MD: − 0.61; 95% CI [− 1.00, − 0.21], I2 = 93%) and MDA (malonaldehyde) (SMD:-1.05; 95% CI [− 1.87, − 0.23], I2 = 94%), suggesting that antioxidants seemed to have therapeutic effects in patients with DKD, especially in reducing proteinuria and hbA1c. The purpose of this study is to provide new targets and ideas for drug research and clinical treatment of DKD.

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ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways

Chi

Zhang

Liang³

et al. 2022

Biol Trace Elem Res

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SLC30A7 has anti-oxidant stress effects in high glucose-induced apoptosis via the NFE2L2/HMOX1 signal transduction pathway

Cited by 4 publications

References 37 publications

Identification of Ferroptosis-related potential biomarkers and immunocyte characteristics in Chronic Thromboembolic Pulmonary Hypertension via bioinformatics analysis

Identification of Ferroptosis-related potential biomarkers and immunocyte characteristics in Chronic Thromboembolic Pulmonary Hypertension via bioinformatics analysis

Effects of antioxidants on diabetic kidney diseases: mechanistic interpretations and clinical assessment

ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways

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