2024
DOI: 10.1101/2024.06.27.600869
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SLC7A5 is required for citrulline-dependent growth in arginine limited conditions

Kyle N. Dunlap,
Austin Bender,
Alexis Bowles
et al.

Abstract: SummaryTumor cells must optimize metabolite acquisition between synthesis and uptake from their surroundings. The tumor microenvironment is characterized by hypoxia, lactate accumulation, and depletion of many circulating metabolites, including amino acids such as arginine. We performed a metabolism-focused functional screen using CRISPR/Cas9 in a melanoma cell line to identify pathways and factors that enable tumor growth in an arginine-depleted environment. Our screen identified the SLC-family transporter SL… Show more

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