Sleep and ADHD: A review article

Mehta, Tejas; Gurung, Puja; Nene, Yash; Fayyaz, Muniba; Bollu, Pradeep C.

doi:10.1007/s40474-019-00178-6

Cited by 4 publications

(3 citation statements)

References 76 publications

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“…So far there is no consensus about the direction of the sleep-ADHD association, despite evidence showing that sleep deprivation and sleep disturbances have known cognitive emotional and behavioral effects that mimic ADHD 3,26,31 , and that early sleep disturbances are associated with an increased risk of ADHD later in life 28,29,31,33,77 . The TSMR analyses we carried out showed a causal effect of insomnia, daytime napping, and short sleep duration on ADHD.…”

Section: Discussionmentioning

confidence: 99%

“…The direction of the association and whether there is a causal effect are unanswered questions and hot topics of a current debate in the field 26 . Sleep deprivation and sleep problems are known to mimic or aggravate ADHD symptoms, and to regulate emotion, cognition and behavior 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…Sleep deprivation and sleep problems are known to mimic or aggravate ADHD symptoms, and to regulate emotion, cognition and behavior 3,4 . On the other hand, ADHD-like behaviors may also lead to altered patterns of sleep 26,27 . Early sleep disturbances predicting ADHD in the future are supported by longitudinal evidence [28][29][30][31][32] .…”

Section: Introductionmentioning

confidence: 99%

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Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: Shared genetic risk factors, molecular mechanisms, and causal effects

Carpena

Bonilla

Matijasevich

et al. 2021

The World Journal of Biological Psychiatry

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: Shared genetic risk factors, molecular mechanisms, and causal effects

Carpena

Bonilla

Matijasevich

et al. 2021

The World Journal of Biological Psychiatry

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Childhood Physical Health and Attention Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Modifiable Factors

Dziuban

Pedati³

et al. 2022

Prev Sci

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Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: shared genetic risk factors, molecular mechanisms, and causal effects

Carpena

Bonilla

Matijasevich

et al. 2020

Preprint

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Study Objectives: To evaluate the level of shared genetic components between attention-deficit/hyperactivity disorder (ADHD) and sleep phenotype, common pathways between them and a possible causal relationship between traits. Methods: We used summary statistics of the largest genome-wide association studies available for ADHD and sleep-related phenotypes including insomnia, napping, daytime dozing, snoring, ease getting up, daytime sleepiness, sleep duration and chronotype. We estimated the genomic correlation between ADHD and sleep-related traits using cross-trait LD-score regression and investigated potential common mechanisms using gene-based cross-trait metanalyses and functional enrichment analyses. The causal effect between the sleep related traits and ADHD was estimated with two sample Mendelian randomization (TSMR), using the Inverse Variance Weighted method as the main estimator. Results: Positive genomic correlation between insomnia, daytime napping, daytime dozing, snoring, daytime sleepiness, short and long sleep duration, and ADHD were observed. Insomnia, sleep duration, daytime sleepiness, and snoring shared genes with ADHD, which were involved in neurobiological functions and regulatory signaling pathways. The TSMR approach supported a causal effect of insomnia, daytime napping, and short sleep duration on ADHD, and of ADHD on long sleep duration and chronotype. Conclusion: Our findings suggest that the comorbidity between sleep phenotypes and ADHD may be mediated by common genetic factors with an important role on neuronal signaling pathways. In addition, it may also exist a causal effect of sleep disturbances and short sleep duration on ADHD, reinforcing the role of these sleep phenotypes as predictors or early markers of ADHD.

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Sleep and ADHD: A review article

Cited by 4 publications

References 76 publications

Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: Shared genetic risk factors, molecular mechanisms, and causal effects

Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: Shared genetic risk factors, molecular mechanisms, and causal effects

Childhood Physical Health and Attention Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Modifiable Factors

Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: shared genetic risk factors, molecular mechanisms, and causal effects

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