Sleep and Breathing … and Cancer?

Owens, Robert L.; Gold, Kathryn A.; Gozal, David; Peppard, Paul E.; Jun, Jonathan C.; Dannenberg, Andrew J.; Lippman, Scott M.; Malhotra, Atul

doi:10.1158/1940-6207.capr-16-0092

Cited by 31 publications

(9 citation statements)

References 56 publications

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“…4 In rats, constant light exposure increases susceptibility to the development of mammary tumors. 5 The mechanisms underlying this effect are unknown.…”

Section: Introductionmentioning

confidence: 99%

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Sleep characteristics, light at night and breast cancer risk in a prospective cohort

White

Weinberg

Park

et al. 2017

Intl Journal of Cancer

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Increasing numbers of women in the US are getting too little sleep. Inadequate sleep has been associated with impaired metabolic function and endocrine disruption. Sister Study cohort participants (n=50,884), completed baseline and follow-up questionnaires on sleep patterns. Incident breast cancers estrogen receptor (ER) status of the tumor were ascertained from questionnaires and medical records. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs). Analyses of sleep characteristics reported at the first follow-up interview included only participants who were breast cancer-free at time of follow-up interview. Over ~7 years of follow-up, 2,736 breast cancer cases (invasive and ductal carcinoma in situ) were diagnosed. There was little evidence that usual sleep duration or other sleep characteristics were associated with breast cancer. However, relative to those with no difficulty sleeping, women who reported having difficulty sleeping ≥ 4 nights a week were at an increased risk of overall (HR=1.32, 95% CI: 1.09–1.61) and postmenopausal breast cancer (HR=1.51, 95% CI 1.24–1.85). Risk of ER+ invasive cancer was elevated for women who reported having a light or television on in the room while sleeping (HR=1.20, 95% CI: 0.97–1.47) or who typically got less sleep than they needed to feel their best (HR=1.21, 95% CI: 0.98–1.50). In our study, most sleep characteristics, including sleep duration, were not associated with an increased risk although higher risk was observed for some markers of inadequate or poor quality sleep.

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“…4 In rats, constant light exposure increases susceptibility to the development of mammary tumors. 5 The mechanisms underlying this effect are unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Inadequate or interrupted sleep and the resulting disruptions in circadian rhythm have been associated with numerous health outcomes, including obesity and metabolic disorders, 3 as well as cancer. 4 In rats, constant light exposure increases susceptibility to the development of mammary tumors. 5 The mechanisms underlying this effect are unknown.…”

mentioning

confidence: 99%

Sleep characteristics, light at night and breast cancer risk in a prospective cohort

White

Weinberg

Park

et al. 2017

Intl Journal of Cancer

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“…There is recent epidemiological data suggesting that OSA is carcinogenic, the potential existence of severe OSA and cancer has gained increasing attention in the last decade. 94 The mechanism is not yet clear, multiple studies still going. Animal exposed to chronic intermittent hypoxia and sleep fragmentation can trigger oxidative stress and chronic inflammation, enhance oncogenic pathway, the data here still primitive and need to be observed.…”

Section: Consequences Of Sleep-disordered Breathingmentioning

confidence: 99%

Diagnosis and management of childhood sleep-disordered breathing

Al-Shamrani

Alharbi‎

2020

SMJ

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Sleep-disordered breathing (SDB) includes disorders of breathing that affect airway patency, which impair children's sleep and lead to negative consequences. Obstructive sleep apnea, hypoventilation and upper airway resistance syndrome are common causes of morbidity and mortality in childhood. These clinical practice guidelines, intended for use by pediatricians and primary care clinicians, provide a clear recommendation for the diagnosis and management of sleep-disordered breathing, focusing on the most serious disorder, obstructive sleep apnea syndrome (OSAS). These clinical guidelines formulate clear recommendations to identify patients with suspected OSAS. Further, the manuscript will highlight the potential consequences of SBD in children, and how to overcome such difficulties, what could be the therapeutic options, a 12 recommendations and what are the future direction for pediatric sleep medicine.

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“…. S101 [65], Demenz [79], Metabolisches Syndrom [80], Krebserkrankungen [81], Dysbiose [82] und Diabetes mellitus [83]. Es zeigen sich auch Gender-assoziierte Unterschiede bezüglich Prävalenz und Krankheitsfolgen [84].…”

Section: Szenario 2025 Und Maßnahmenkatalog (Siehe Tab 1)unclassified

Masterplan 2025 der Österreichischen Gesellschaft für Pneumologie (ÖGP) – die erwartete Entwicklung und Versorgung respiratorischer Erkrankungen in Österreich

Studnicka

Baumgartner²,

Bolitschek

et al. 2020

Wien Klin Wochenschr

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Zusammenfassung Mitglieder der Österreichischen Gesellschaft für Pneumologie (ÖGP) beschreiben die erwartete Entwicklung der respiratorischen Gesundheit und zeigen Wege einer patientenorientierten und kosteneffizienten Versorgung für Österreich auf. Methoden: Im November 2017 trifft sich eine Gruppe von respiratorisch tätigen Ärzten, Pflegekräften und Physiotherapeuten, gemeinsam mit Vertretern von Selbsthilfe-Gruppen und Experten für Gesundheitsentwicklung, um die Themen Rahmenbedingungen für Lungengesundheit, Asthma und Allergie, COPD, Mukoviszidose und andere Krankheitsbilder der pädiatrischen Pneumologie, Infektionen in der Pneumologie, Schlafbezogene Atemstörungen, Interventionelle Pneumologie, Thorakale Onkologie, und Orphan Diseases zu bearbeiten. Ergebnisse: Respiratorische Erkrankungen sind extrem häufig und werden sehr oft durch individuelles Fehlverhalten (Zigarettenrauchen, Überernährung, körperliche Inaktivität) verursacht. Zudem wird für respiratorische Erkrankungen eine Zunahme der Prävalenz, aber eine Abnahme der Hospitalisierungen erwartet. Folgende Maßnahmen sind erforderlich, um den Herausforderungen der Zukunft zu begegnen. 1. Maßnahmen des Screenings und der Fallfindung sollen für Lungenkarzinom und COPD umgesetzt werden. 2. E-Health (Telemedizin, personalisierte Apps) soll vermehrt eingesetzt werden mit dem Ziel das Patientenmanagement zu erleichtern. 3. Regionale Unterschiede der medizinischen Versorgung können durch E‑Health und Harmonisierung der Angebote der Gesundheitskassen reduziert werden. 4. Patientenschulung und Awareness für respiratorische Erkrankungen soll verbessert werden (essentiell für Schlafstörungen, aber auch für andere respiratorische Erkrankungen) 5. Die angebotene Versorgung soll interprofessionell, und auf der Grundlage erkrankungsspezifischer Boards wie bei Tumorboards (z. B. für interstitielle Lungenerkrankungen, Schlaf und Allergie) erfolgen. 6. Die ambulante Rehabilitation im niedergelassenen Bereich kann einen großen Beitrag zur respiratorischen Gesundheit leisten. 7. Das vermehrte Verständnis der Molekularbiologie wird die personalisierte Medizin und zielgerichtete Therapien (z. B. für Asthma, Lungenkarzinom) ermöglichen, aber auch Gesundheitskosten verändern.

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Sleep and Breathing … and Cancer?

Cited by 31 publications

References 56 publications

Sleep characteristics, light at night and breast cancer risk in a prospective cohort

Sleep characteristics, light at night and breast cancer risk in a prospective cohort

Diagnosis and management of childhood sleep-disordered breathing

Masterplan 2025 der Österreichischen Gesellschaft für Pneumologie (ÖGP) – die erwartete Entwicklung und Versorgung respiratorischer Erkrankungen in Österreich

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