Sleep and cancer: Recent developments

Sateia, Michael J.; Lang, B.J.

doi:10.1007/s11912-008-0049-0

Cited by 84 publications

(56 citation statements)

References 47 publications

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“…Cancer patients report a high frequency of sleep disturbance [28]. The current data demonstrate that EAT inoculation altered sleep patterns by increasing paradoxical sleep.…”

Section: Discussionmentioning

confidence: 62%

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Maragno-Correa

Patti

Zanin

et al. 2013

Neuroimmunomodulation

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Objectives: Sleep deprivation is a growing public health hazard, yet it is still under-recognized. Sleep disorders and disruption of sleep patterns may compromise the immune function and adversely affect host resistance to infectious diseases. This is a particular risk in cancer patients, who report a high frequency of sleep disturbances. The present study investigated the effects of sleep deprivation on the development of Ehrlich ascitic tumors (EAT) in female BALB/c mice. Our study also evaluated whether EAT would induce alterations in sleep pattern. Spleen lymphocyte cell populations and mortality were also quantified. Methods: Female BALB/c mice were intraperitoneally inoculated with EAT cells. Immediately after the inoculation procedure, animals were sleep deprived for 72 h. Ten or 15 days after inoculation, the number of tumoral cells was quantified and the lymphocytic cell population in the spleen was characterized by flow cytometry. In addition, the effect of sleep deprivation on EAT-induced mortality was quantified and the influence of EAT on sleep patterns was determined. Results: Sleep deprivation did not potentiate EAT growth, but it significantly increased mortality. Additionally, both EAT and sleep deprivation decreased frequencies of splenic CD4+, CD8+ and CD19+ cells. With respect to sleep patterns, EAT significantly enhanced paradoxical sleep time. Conclusions: Although sleep deprivation did not potentiate EAT growth, it decreased the survival of female tumor-bearing mice.

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“…Cancer patients report a high frequency of sleep disturbance [28]. The current data demonstrate that EAT inoculation altered sleep patterns by increasing paradoxical sleep.…”

Section: Discussionmentioning

confidence: 62%

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Maragno-Correa

Patti

Zanin

et al. 2013

Neuroimmunomodulation

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“…61 Sleep disturbances are commonly experienced by cancer survivors. 62 Increasing age, irregular sleep/wake schedules, depression, anxiety, symptoms (ie, pain, fatigue, nausea and vomiting), changes in hormone and cytokine secretion, cancer therapies, and medications such as analgesics, antidepressants, antiemetics, anxiolytics, and corticosteroids contribute to sleep disturbances in patients with cancer. Disease-related factors also may play a role in disrupting sleep through altered circadian rhythms and the HPA axis regulatory processes before therapy.…”

Section: Disease-and Treatment-related Symptomsmentioning

confidence: 99%

Cognitive and Occupational Function in Survivors of Adolescent Cancer

Nugent

Bender

Sereika

et al. 2018

Journal of Adolescent and Young Adult Oncology

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The number of cancer survivors living in the U.S. is dramatically increasing. Cognitive decline is a commonly reported and burdensome symptom of cancer survivors. In addition, many cancer survivors experience difficulty maintaining employment. This dissertation addresses gaps in the literature of cognitive and occupational function of cancer survivors, with particular emphasis on the understudied population of cancer survivors diagnosed as an adolescent or young adult (AYA). For this dissertation, a series of studies were conducted to 1) explore the association between occupation and symptom burden in breast cancer survivors, 2) synthesize the evidence of cognitive outcomes in survivors of AYA cancer, and 3) describe cognitive and occupational function in survivors of adolescent cancer compared to healthy controls.To address aim one, a secondary analysis of data from early-stage breast cancer survivors explored the relationship between occupation and symptom burden. Breast cancer survivors employed in lower skill level jobs reported greater symptom burden over the first year of anastrozole treatment than women employed at the higher skill level. Survivors employed at lower skill levels had higher levels of fatigue and worse depressive, musculoskeletal, vasomotor, and gastrointestinal symptoms.To address aim two, an integrative review synthesized the current state of science in terms of cognitive outcomes of those diagnosed with cancer as an AYA. Survivors of AYA cancer tended to experience cognitive difficulties; however, to date, no study has focused exclusively on those diagnosed as an AYA or encompassed the entirety of the AYA age range. Future iv studies are needed because cognitive outcomes of survivors of AYA cancer have been largely neglected.Lastly, a cross-sectional, descriptive comparative study described cognitive and occupational function in survivors of adolescent cancer compared to healthy controls. Survivors of adolescent cancer perceived greater cognitive difficulty than healthy peers, although there were not significant measurable differences in performance on neuropsychological tests. Survivors of adolescent cancer also reported poorer work output than healthy controls.This dissertation contributes to the growing body of literature pertaining to health and well-being of cancer survivors, in particular cognitive and occupational function, and unique considerations needed for those diagnosed with cancer as an AYA.v Study 2. While there is a growing body of literature suggesting that many cancer survivors may experience cognitive decline after cancer diagnosis and treatment, much less is known about the cognitive outcomes of those diagnosed during the AYA timeframe. Therefore, the second study of this dissertation is an integrative review to summarize and appraise the current state of published literature involving cognitive function in those diagnosed during adolescence and young adulthood. While the review is a distinct study within the dissertation project, it provides a critically important ...

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“…De fato, estudos sugerem que a dor e o sono mantêm influências mútuas: a dor repercute negativamente na qualidade de sono, e a privação de sono pode aumentar a sensibilidade à dor (Fortner et al, 2002;Sateia & Lang, 2008).…”

Section: Discussionunclassified

Sono, qualidade de vida e depressão em mulheres no pós-tratamento de câncer de mama

Rafihi‐Ferreira¹,

Pires²,

Soares³

2012

Psicol. Reflex. Crit.

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ResumoEste trabalho investigou a qualidade de sono de mulheres com câncer de mama e suas relações com qualidade de vida e depressão. Cinqüenta mulheres com câncer de mama (grupo clínico) e cinqüenta controles responderam um questionário médico-demográfico e ao instrumento Pittsburgh Sleep Quality Index. O grupo clínico também respondeu aos instrumentos Quality of Life Cancer-Survivor e Brief Zung SelfRating Depression Scale. Verificou-se que mulheres com câncer tinham significativamente mais queixas de nictúria, calor e despertares noturnos. O grupo clínico com má qualidade do sono apresentou comprometimento na qualidade de vida e mais sintomas de depressão. Em geral, a qualidade de sono em mulheres com câncer de mama pode predizer a qualidade de vida e o bem estar psicológico. Palavras-chave: Câncer de mama, insônia, qualidade de vida, depressão. AbstractThis study investigated the sleep quality of women with breast cancer and their relationship with quality of life and depression. Fifty women with breast cancer (clinical group) and a control group of other 50 women without the disease answered a clinical-demographic questionnaire and the Pittsburgh Sleep Quality Index. The clinical group also completed the Quality of Life Cancer-Survivor and the Brief Zung SelfRating Depression Scale questionnaires. It was found that women with breast cancer had significantly more complaints of nocturia, heat and nighttime awakenings. The clinical group with poor quality of sleep reported impaired quality of life and more symptoms of depression. In general terms, sleep quality in women with breast cancer can predict their quality of life and psychological well-being. Keywords: Breast cancer, insomnia, quality of life, depression.* Este artigo foi parte da dissertação de mestrado da primeira autora, sob orientação da terceira autora. Este trabalho recebeu apoio financeiro do Conselho Nacional Queixas de sono, particularmente insônia, são freqüen-tes em pacientes com câncer de mama, com prevalências que superam as encontradas na população geral. Os resultados sumarizados em recente revisão sobre o tema e estudos complementares mostram que a prevalência da insônia, tanto na hospitalização, quanto ao longo do tratamento ou depois, pode variar entre 23% e 80% (Bardwell et al., 2008;Fiorentino & Ancoli-Israel, 2006; Furlani & Ceolin, 2006). Contudo, diferentemente da atenção que recebem outras manifestações físicas ou psicológicas que acometem o paciente oncológico, como fadiga, dor, náu-sea, depressão e ansiedade, problemas de sono são vistos como uma reação esperada e temporária, advinda de circunstâncias estressoras que circundam o diagnóstico (impacto emocional, ansiedade, depressão, sensação de incerteza) e do tratamento (hospitalização, procedimentos cirúrgicos, efeitos colaterais de medicação como náusea e vômito). No entanto, embora tal miríade de estressores seja o evento precipitante, a dificuldade em obter um sono de boa qualidade e de duração adequada pode se perpetuar em decorrência do estabelecimento de hábitos inadeq...

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Sleep and cancer: Recent developments

Cited by 84 publications

References 47 publications

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Cognitive and Occupational Function in Survivors of Adolescent Cancer

Sono, qualidade de vida e depressão em mulheres no pós-tratamento de câncer de mama

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