Sleep and Cardiovascular Disease

Wołk, Robert; Gami, Apoor S.; García‐Touchard, Arturo; Somers, Virend K.

doi:10.1016/j.cpcardiol.2005.07.002

Cited by 270 publications

(210 citation statements)

References 197 publications

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“…Sleep abnormalities are associated with poor cardiovascular outcomes (14,15). OSA is an important health care problem which is also linked to cardiovascular risk factors including HT, DM, HL, obesity, coronary artery disease, and stroke (16).…”

Section: Discussionmentioning

confidence: 99%

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

Sünbül¹,

Sünbül²,

Kanar³

et al. 2015

BLL

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BACKGROUND: Obstructive sleep apnea (OSA) is characterized by reductions in breathing amplitude during sleep caused by an obstructed or collapsed upper airway. The neutrophil to lymphocyte ratio (NLR) has been proposed as a novel biomarker for systemic infl ammatory response. The aim of the present study was to evaluate the relationship between NLR and OSA. METHODS: The study population consisted of 195 consecutive patients with clinical suspicion of OSA. Full night polysomnography was performed for all patients. Patients with an apnea hypopnea index (AHI) ≥ 5 were considered to have OSA. NLR was calculated as the ratio of neutrophil count to lymphocyte count. RESULTS: While 130 patients (91 male, mean age: 49.9±9.8 years) had OSA, 65 patients (42 male, mean age: 48.7 ± 10.2 years) had normal fi ndings according to AHI scores. Cardiovascular risk factors such as hypertension, hyperlipidemia, diabetes mellitus and smoking were more common in patients with OSA. Patients with OSA had signifi cantly higher NLR than controls (1.87±0.80 vs 1.49±0.48, p=0.005). AHI score was signifi cantly correlated with NLR (r=0.228, p=0.001). NLR and presence of hyperlipidemia were independent predictors of OSA (OR: 2.451, 2.850, p=0.001, 0.004, respectively). NLR of 1.62 or higher predicted OSA with a sensitivity of 56.2 % and specifi city of 63.1 %. CONCLUSIONS: NLR was higher and also correlated with AHI score in patients with OSA which has not been reported previously. NLR more than 1.62 was an independent predictor of OSA. A simple, cheap white blood cell count may also give an idea about the presence and severity of OSA (Tab. 3, Fig. 3, Ref. 30). Text in PDF www.elis.sk. KEY WORDS: infl ammation, cardiovascular risk, neutrophil to lymphocyte ratio, obstructive sleep apnea.

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Section: Discussionmentioning

confidence: 99%

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

Sünbül¹,

Sünbül²,

Kanar³

et al. 2015

BLL

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“…Poor sleep quality has been linked to several health problems such as cardiovascular disease (5,6), obesity (7), diabetes (8), depression and anxiety (9)(10)(11), and is a risk factor for mortality (12)(13)(14). Previous research has shown that (chronic) stress is an important antecedent of poor sleep quality and that work can be an important cause of stress (15).…”

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confidence: 99%

Psychosocial work characteristics and sleep quality: a systematic review of longitudinal and intervention research

Laethem¹,

Beckers²,

Kompier³

et al. 2013

Scand J Work Environ Health

102

100

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“…Experimental studies have revealed that chronic sleep deprivation is associated with a number of negative health outcomes, including metabolic syndrome (Bass and Turek 2005;Spiegel et al 2005;Wolk et al 2005;Jennings et al 2007;Hall et al 2008). Metabolic syndrome is defined by the coexistence of several diagnostic factors.…”

mentioning

confidence: 99%

Association between Short Sleep Duration and High Incidence of Metabolic Syndrome in Midlife Women

Choi

Kim

et al. 2011

Tohoku J. Exp. Med.

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Chronic sleep deprivation is increasingly common in industrialized societies. Short sleep duration has been associated with a number of negative health outcomes. The objectives of this study were to investigate the association between self-reported sleep duration and the presence of metabolic syndrome (combination of central obesity, triglyceride, high density lipoprotein, blood pressure, fasting plasma glucose) in adults during midlife. The Korean Genomic Rural Cohort (KGRC) is a cohort study of aged 40 to 70 years in rural Korea. This study focuses on the prevalence, incidence, and risk factors for chronic degenerative disorders, such as hypertension, diabetes, osteoporosis, respiratory diseases, and metabolic syndrome. The baseline sample of participants in the KGRC study was recruited in 2005-2006 (phase 1). Respondents were followed until 2008-2009 (phase 2). The final sample included 1,107 subjects: 386 males (34.9%) and 721 females (65.1%). The incidence rate of metabolic syndrome in our sample was 18.4% (21.2% for males and 16.9% for females). Subjects sleeping < 6 hours a day (HR: 1.798; 95% CI: 1.06-3.05) were significantly more likely to experience metabolic syndrome than participants sleeping 6 to 7.9 hours a day after controlling for potential covariates (age, body mass index, menopause, smoking, alcohol and physical activity). Shorter sleep duration was associated with the high incidence of metabolic syndrome among females only. In conclusion, shorter sleep duration may be a significant risk factor for the development of metabolic syndrome in women.

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Sleep and Cardiovascular Disease

Cited by 270 publications

References 197 publications

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

Psychosocial work characteristics and sleep quality: a systematic review of longitudinal and intervention research

Association between Short Sleep Duration and High Incidence of Metabolic Syndrome in Midlife Women

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