Sleep and circadian contributions to adolescent alcohol use disorder

Hasler, Brant P.; Soehner, Adriane M.; Clark, Duncan B.

doi:10.1016/j.alcohol.2014.06.010

Cited by 100 publications

(73 citation statements)

References 168 publications

(209 reference statements)

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“…This suggests that the oft-noted cross-sectional associations between circadian preference and reward-related processes and behaviors are not primarily driven by impulsive, reward-seeking behavior, and/or substance use leading to later bedtimes and rise times. Rather, our findings are consistent with a burgeoning animal and human literature supporting sleep and circadian modulation of reward processes and behavior, with relevance to both affective disorders and addiction (reviewed in (55, 56). …”

Section: Discussionsupporting

confidence: 89%

Eveningness among late adolescent males predicts neural reactivity to reward and alcohol dependence 2 years later

Hasler

Casement

Sitnick

et al. 2017

Behavioural Brain Research

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Eveningness, a preference for later sleep-wake timing, is linked to altered reward function, which may explain a consistent association with substance abuse. Notably, the extant literature rests largely on cross-sectional data, yet both eveningness and reward function show developmental changes. We examined whether circadian preference during late adolescence predicted the neural response to reward two years later. A sample of 93 males reported circadian preference and completed a monetary reward fMRI paradigm at ages 20 and 22. Primary analyses examined longitudinal paths from circadian preference to medial prefrontal cortex (mPFC) and ventral striatal (VS) reward responses. We also explored whether reward responses mediated longitudinal associations between circadian preference and alcohol dependence, frequency of alcohol use, and/or frequency of cannabis use. Age 20 eveningness was positively associated with age 22 mPFC and VS responses to win, but not associated with age 22 reactivity to reward anticipation. Age 20 eveningness was indirectly related to age 22 alcohol dependence via age 22 mPFC response to win. Our findings provide novel evidence that altered reward-related brain function could underlie associations between eveningness and alcohol use problems. Eveningness may be an under-recognized but modifiable risk factor for reward-related problems such as mood and substance use disorders.

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Section: Discussionsupporting

confidence: 89%

Eveningness among late adolescent males predicts neural reactivity to reward and alcohol dependence 2 years later

Hasler

Casement

Sitnick

et al. 2017

Behavioural Brain Research

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“…These findings buttress a growing literature indicating that childhood and adolescent sleep disturbance is a vulnerability factor for substance involvement, possibly operating through mood disorders or altered reward mechanisms (Hasler & Clark, 2013;Hasler et al, 2015). Fortunately, sleep problems are a modifiable risk factor; the means to address this vulnerability are available at both the individual and systemic levels.…”

Section: Discussionmentioning

confidence: 54%

Restless Sleep and Variable Sleep Timing During Late Childhood Accelerate the Onset of Alcohol and Other Drug Involvement

Hasler

Kirisci

Clark

2016

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Limited prospective data indicate that premorbid sleep disturbances elevate the risk for subsequent alcohol and other drug problems, yet the implications for subsequent substance involvement trajectories remain unclear. In the present analyses, we examined risk associations between sleep characteristics during late childhood and the onset of substance use and substance use disorders into adulthood. Method: A sample of 707 children was recruited at ages 9-13 years and followed over seven additional visits through age 30 years. In 304 participants, fathers had a history of substance use disorder involving illicit drugs. Self-reported baseline sleep characteristics (restless sleep and variable sleep timing) were assessed at approximately ages 9-13 years. Assessment of alcohol, cannabis, and cocaine involvement occurred at follow-up visits. Cox proportional hazard models tested sleep characteristics as predictors of two substance-related outcomes (age at first use or diagnosis of disorder), as well as the onset of major depressive disorder. Results: Restless sleep at baseline significantly predicted an earlier onset age for trying alcohol and cannabis and showed a trend toward predicting early onset of cannabis use disorder. Restless sleep also predicted an earlier onset of depression. Irregular sleep timing at baseline significantly predicted an earlier onset age for alcohol use disorder and showed trends toward predicting early onsets of disorders of cannabis and cocaine use. Conclusions: Disturbed sleep during late childhood appears to accelerate the onset of not only initial substance use but also the development of clinically defined substance use disorder. Sleep-focused preventative efforts during late childhood may reduce the incidence of mood and substance use disorders. (J. Stud. Alcohol Drugs, 77, 649-655, 2016)

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“…Kohyama (2009Kohyama ( , 2011 terms this condition asynchronization, which in principle is equivalent to circadian disruption. Finally, eveningness in young adults is linked to risk for excess alcohol consumption and addiction (Adan, 1994;Hasler et al, 2012Hasler et al, , 2013Hasler et al, , 2015Wittmann et al, 2010). As discussed earlier, routine alcohol consumption, itself, may cause CD.…”

Section: Discussionmentioning

confidence: 95%

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Smolensky

Hermida

Reinberg

et al. 2016

Chronobiology International

155

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Biological processes are organized in time as innate rhythms defined by the period (τ), phase (peak [Φ] and trough time), amplitude (A, peak-trough difference) and mean level. The human time structure in its entirety is comprised of ultradian (τ < 20 h), circadian (20 h > τ < 28 h) and infradian (τ > 28 h) bioperiodicities. The circadian time structure (CTS) of human beings, which is more complicated than in lower animals, is orchestrated and staged by a brain central multioscillator system that includes a prominent pacemaker - the suprachiasmatic nuclei of the hypothalamus. Additional pacemaker activities are provided by the pineal hormone melatonin, which circulates during the nighttime, and the left and right cerebral cortices. Under ordinary circumstances this system coordinates the τ and Φ of rhythms driven by subservient peripheral cell, tissue and organ clock networks. Cyclic environmental, feeding and social time cues synchronize the endogenous 24 h clocks and rhythms. Accordingly, processes and functions of the internal environment are integrated in time for maximum biological efficiency, and they are also organized and synchronized in time to the external environment to ensure optimal performance and response to challenge. Artificial light at night (ALAN) exposure can alter the CTS as can night work, which, like rapid transmeridian displacement by air travel, necessitates realignment of the Φ of the multitude of 24 h rhythms. In 2001, Stevens and Rea coined the phrase "circadian disruption" (CD) to label the CTS misalignment induced by ALAN and shift work (SW) as a potential pathologic mechanism of the increased risk for cancer and other medical conditions. Current concerns relating to the effects of ALAN exposure on the CTS motivated us to renew our long-standing interest in the possible role of CD in the etiopathology of common human diseases and patient care. A surprisingly large number of medical conditions involve CD: adrenal insufficiency; nocturia; sleep-time non-dipping and rising blood pressure 24 h patterns (nocturnal hypertension); delayed sleep phase syndrome, non-24 h sleep/wake disorder; recurrent hypersomnia; SW intolerance; delirium; peptic ulcer disease; kidney failure; depression; mania; bipolar disorder; Parkinson's disease; Smith-Magenis syndrome; fatal familial insomnia syndrome; autism spectrum disorder; asthma; byssinosis; cancers; hand, foot and mouth disease; post-operative state; and ICU outcome. Poorly conceived medical interventions, for example nighttime dosing of synthetic corticosteroids and certain β-antagonists and cyclic nocturnal enteral or parenteral nutrition, plus lifestyle habits, including atypical eating times and chronic alcohol consumption, also can be causal of CD. Just as surprisingly are the many proven chronotherapeutic strategies available today to manage the CD of several of these medical conditions. In clinical medicine, CD seems to be a common, yet mostly unrecognized, pathologic mechanism of human disease as are the many effective chronotherapeutic int...

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Sleep and circadian contributions to adolescent alcohol use disorder

Cited by 100 publications

References 168 publications

Eveningness among late adolescent males predicts neural reactivity to reward and alcohol dependence 2 years later

Eveningness among late adolescent males predicts neural reactivity to reward and alcohol dependence 2 years later

Restless Sleep and Variable Sleep Timing During Late Childhood Accelerate the Onset of Alcohol and Other Drug Involvement

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

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