Sleep and Circadian Rhythm Disruption in Psychosis

Peirson, Stuart N.; Foster, Russell G.

doi:10.1002/9781118467831.ch18

Cited by 8 publications

(7 citation statements)

References 50 publications

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“…However, sleep disorders and sleep-wake cycle alterations have been known as common and consistent features of schizophrenia and other psychotic disorders since the first definition of Kraepelin in 1883. 205 Schizophrenia has been associated with abnormalities in sleep includ-ing delayed and advanced sleep onset, altered resting activity patterns, and irregular sleep-wake cycle. 206 Research into circadian abnormalities and sleep disruption in schizophrenia has attempted to explain the causal relationship in a reciprocal context.…”

Section: Schizophreniamentioning

confidence: 99%

“…Although the relationship between mood disorders and circadian abnormalities has become clearer in recent times, the links between schizophrenia and disrupted circadian rhythms have yet to be elucidated fully. However, sleep disorders and sleep-wake cycle alterations have been known as common and consistent features of schizophrenia and other psychotic disorders since the first definition of Kraepelin in 1883 [ 205 ]. Schizophrenia has been associated with abnormalities in sleep including delayed and advanced sleep onset, altered resting activity patterns, and irregular sleep-wake cycle [ 206 ].…”

Section: Circadian Rhythm and Its Implications On Psychiatric Disordementioning

confidence: 99%

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Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2020

Psychiatry Investig

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Objective Several lines of evidence support a relationship between circadian rhythms disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities.Methods The Medline, Embase, PsycInfo, and Scopus databases were comprehensively and systematically searched and articles published between January 1990 and October 2019 were reviewed. Different combinations of the relevant keywords were polled. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders.Results Although subject characteristics and study designs vary across studies, current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. Impaired HPA-axis function-related glucocorticoid rhythm and disrupted melatonin homeostasis have been prominently demonstrated in schizophrenia and other psychotic disorders, while alterations of molecular expressions of circadian rhythm genes including <i>CLOCK, PER</i>, and <i>CRY</i> have been reported to be involved in the pathogenesis of mood disorders.Conclusion Further translational work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders and related psychopathology, and to develop sound pharmacologic interventions.

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Section: Schizophreniamentioning

confidence: 99%

Section: Circadian Rhythm and Its Implications On Psychiatric Disordementioning

confidence: 99%

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2020

Psychiatry Investig

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“…Glutamate and GABA may play a role in the pathophysiology of sleep disorders in schizophrenia, but there is not yet enough evidence to confirm this 13 , 16 , 38 . Serotonergic, orexinergic, and cholinergic systems are also involved in the pathophysiology of both schizophrenia and sleep disorders 39 .…”

Section: Discussionmentioning

confidence: 99%

Sleep quality impairments in schizophrenia and bipolar affective disorder patients continue during periods of remission: a case-controlled study

Hacımusalar¹,

Karaaslan²,

Mısır³

et al. 2022

Sleep Sci

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Objective Bipolar disorder (BD) and schizophrenia are chronic psychiatric disorders in which sleep disorders are commonly seen. In mental disorders, residual symptoms may persist even if symptoms are greatly reduced overall. The aim of this study was to compare the sleep quality of schizophrenia and BD patients in remission with that of healthy controls. Methods Forty-three patients with schizophrenia, 46 BD patients in remission for at least 3 months, and 51 healthy controls were included the study. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Young Mania Rating Scale (YMRS) and Pittsburgh Sleep Quality Index (PSQI) were administered to all participants and the Positive and Negative Syndrome Scale (PANSS) was administered to patients with schizophrenia. Results Poor sleep quality was more frequent in the patient groups than the control group ( p =0.009). PSQI score was positively correlated with duration of disease ( r =0.236; p =0.026), number of cigarettes smoked per day ( r =0.430; p <0.001), body mass index ( r =0.189; p =0.025), and negatively correlated with duration of remission ( r =-0.224; p =0.0359). Conclusion Schizophrenia and BD patients in remission had worse sleep quality than a control group. Sleep quality was worst in the patients with schizophrenia. The severity of sleep disorder symptoms was positively associated with disease duration and negatively associated with duration of remission. Schizophrenia and BD patients should be carefully evaluated for symptoms of sleep disorders even when they are in clinical remission and should be offered additional treatment for sleep disorder symptoms when necessary.

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“…Physiological circadian rhythms are an important component of organismal well-being, and disruption of the internal body clock can lead to detrimental and pathophysiological effects [ 14 ]. This is followed directly from recent literature related to biological rhythms in different systems [ 15 , 16 , 17 ]. Many of these studies investigate the problem using systems biology approaches [ 18 , 19 ], for example by studying large-scale transcript or protein profiles.…”

Section: Discussionmentioning

confidence: 99%

Deciphering the Duality of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome

et al. 2016

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Oscillations in circadian metabolism are crucial to the well being of organism. Our understanding of metabolic rhythms has been greatly enhanced by recent advances in high-throughput systems biology experimental techniques and data analysis. In an in vitro setting, metabolite rhythms can be measured by time-dependent sampling over an experimental period spanning one or more days at sufficent resolution to elucidate rhythms. We hypothesized that cellular metabolic effects over such a time course would be influenced by both oscillatory and circadian-independent cell metabolic effects. Here we use nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling of mammalian cell culture media of synchronized U2 OS cells containing an intact transcriptional clock. The experiment was conducted over 48 h, typical for circadian biology studies, and samples collected at 2 h resolution to unravel such non-oscillatory effects. Our data suggest specific metabolic activities exist that change continuously over time in this settting and we demonstrate that the non-oscillatory effects are generally monotonic and possible to model with multivariate regression. Deconvolution of such non-circadian persistent changes are of paramount importance to consider while studying circadian metabolic oscillations.

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Sleep and Circadian Rhythm Disruption in Psychosis

Cited by 8 publications

References 50 publications

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Sleep quality impairments in schizophrenia and bipolar affective disorder patients continue during periods of remission: a case-controlled study

Deciphering the Duality of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome

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