Sleep and circadian rhythm disturbance in bipolar disorder

Bradley, Andrew J.; Webb-Mitchell, R; Hazu, A; Slater, Naomi; Middleton, Benita; Gallagher, Peter; McAllister-Williams, R. Hamish; Anderson, Kelly

doi:10.1017/s0033291717000186

Cited by 96 publications

(86 citation statements)

References 39 publications

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“…Sleep disturbances have also been reported to be frequent in the euthymic state . Past studies have demonstrated that the sleep disturbances in the euthymic state included not only insomnia but also sleep–wake rhythm disorders, especially delayed sleep–wake phase disorders, suggesting that circadian rhythm dysfunction could be involved in the pathophysiology of BD. Pinho et al .…”

Section: Circadian Rhythm Markers In Bdmentioning

confidence: 99%

Circadian rhythm in bipolar disorder: A review of the literature

Takaesu

2018

Psychiatry Clin Neurosci

158

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Sleep disturbances and circadian rhythm dysfunction have been widely demonstrated in patients with bipolar disorder (BD). Irregularity of the sleep-wake rhythm, eveningness chronotype, abnormality of melatonin secretion, vulnerability of clock genes, and the irregularity of social time cues have also been well-documented in BD. Circadian rhythm dysfunction is prominent in BD compared with that in major depressive disorders, implying that circadian rhythm dysfunction is a trait marker of BD. In the clinical course of BD, the circadian rhythm dysfunctions may act as predictors for the first onset of BD and the relapse of mood episodes. Treatments focusing on sleep disturbances and circadian rhythm dysfunction in combination with pharmacological, psychosocial, and chronobiological treatments are believed to be useful for relapse prevention. Further studies are therefore warranted to clarify the relation between circadian rhythm dysfunction and the pathophysiology of BD to develop treatment strategies for achieving recovery in BD patients.

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Section: Circadian Rhythm Markers In Bdmentioning

confidence: 99%

Circadian rhythm in bipolar disorder: A review of the literature

Takaesu

2018

Psychiatry Clin Neurosci

158

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“…There is considerable evidence of circadian rhythm dysfunction in patients with bipolar disorder including disturbances in the sleep/wake cycle, activity patterns, melatonin secretion, as well as suggestive associations with clock gene polymorphisms and epigenetic alterations . Clinical symptoms that are frequently reported include sleep timing disturbances , irregular daily schedules , and an evening preference .…”

Section: Introductionmentioning

confidence: 99%

Solar insolation in springtime influences age of onset of bipolar I disorder

Bauer

Glenn²,

Alda

et al. 2017

Acta Psychiatr Scand

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“…At least three possible explanations may be worth considering in regards to the link between BD and the risk of OSA: Different types of sleep disturbance are described in all phases of BD, including remission . Sympathetic hyperactivity and hyperarousal states associated with sleep disturbance may lead to instability of the upper respiratory tract, which may contribute to subsequent OSA …”

Section: Discussionmentioning

confidence: 99%

“…• Different types of sleep disturbance are described in all phases of BD, including remission. 13 Sympathetic hyperactivity and hyperarousal states associated with sleep disturbance may lead to instability of the upper respiratory tract, which may contribute to subsequent OSA. 14 • Benzodiazepines, which have a sedative effect, are therefore prescribed to relieve these sleep problems.…”

Section: Discussionmentioning

confidence: 99%

Risk of obstructive sleep apnea in patients with bipolar disorder: A nationwide population‐based cohort study in Taiwan

Chang

Chen²,

Chiang

et al. 2018

Psychiatry Clin Neurosci

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Aim Previous studies have found a high prevalence of risk factors for obstructive sleep apnea (OSA) in patients with bipolar disorder (BD). This study aimed to determine whether BD patients are associated with an increased risk of incident OSA. Methods Using the National Health Insurance Research Database of Taiwan, 3650 BD patients and 18 250 non‐BD controls matched by sex and age were enrolled between 2000 and 2010 and followed until the end of 2013. Patients who developed OSA confirmed by a polysomnographic examination during the follow‐up period were identified. Cox regression analysis was performed to examine the risk of OSA between BD patients and comparative controls. Results BD patients were prone to developing OSA in the crude analysis (hazard ratio [HR]: 1.63, 95% confidence interval [CI]: 1.07–2.49). After adjusting for demographics and comorbidities, the HR declined and was only marginally significant (HR: 1.54, 95%CI: 0.99–2.37). The stratification analysis by sex revealed that the risk trend with BD and subsequent OSA was mainly contributed by male BD patients (HR: 1.72, 95%CI: 1.02–2.91) and female BD patients weakened the overall association. Additionally, this study found that older age, higher income, living in urbanized areas, and some metabolic comorbidities were potential risk factors for developing OSA. Conclusion This study shows that male BD patients are associated with an increased risk of OSA, which has direct implications for the development of targeted prevention interventions or the implementation of a screening algorithm for OSA to reduce its negative health impact.

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Sleep and circadian rhythm disturbance in bipolar disorder

Abstract: Background

Cited by 96 publications

References 39 publications

Circadian rhythm in bipolar disorder: A review of the literature

Circadian rhythm in bipolar disorder: A review of the literature

Solar insolation in springtime influences age of onset of bipolar I disorder

Risk of obstructive sleep apnea in patients with bipolar disorder: A nationwide population‐based cohort study in Taiwan

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