Sleep and Cognitive Function in Multiple Sclerosis

Braley, Tiffany J.; Kratz, Anna L.; Kaplish, Neeraj; Chervin, Ronald D.

doi:10.5665/sleep.6012

Cited by 82 publications

(59 citation statements)

References 44 publications

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“…As no definition has been previously published for the five items version of the AIS, we defined sleep disturbances as scoring at least three points (i.e., median score of patients) with the prerequisite of scoring moderate to severe on at least one item, thereby aiming to be a bit more conservative than using, for instance, a median split approach. A previous study has shown that objective measures of sleep disturbances, such as obstructive sleep apnea, can be related to cognitive dysfunction in MS [37]. Hence, objective measures to quantify sleep disturbances, such as polysomnography, might give a more precise reflection than a self-report questionnaire of the sleep deficits being present.…”

Section: Discussionmentioning

confidence: 99%

The role of sleep on cognition and functional connectivity in patients with multiple sclerosis

et al. 2016

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Sleep disturbances are common in multiple sclerosis (MS), but its impact on cognition and functional connectivity (FC) of the hippocampus and thalamus is unknown. Therefore, we investigated the relationship between sleep disturbances, cognitive functioning and resting-state (RS) FC of the hippocampus and thalamus in MS. 71 MS patients and 40 healthy controls underwent neuropsychological testing and filled out self-report questionnaires (anxiety, depression, fatigue, and subjective cognitive problems). Sleep disturbances were assed with the five-item version of the Athens Insomnia Scale. Hippocampal and thalamic volume and RS FC of these regions were determined. Twenty-three patients were categorized as sleep disturbed and 48 as normal sleeping. No differences were found between disturbed and normal sleeping patients concerning cognition and structural MRI. Sleep disturbed patients reported more subjective cognitive problems, and displayed decreased FC between the thalamus and middle and superior frontal gyrus, inferior frontal operculum, anterior cingulate cortex, inferior parietal gyrus, precuneus, and angular gyrus compared to normal sleeping patients. We conclude that sleep disturbances in MS are not (directly) related to objective cognitive functioning, but rather to subjective cognitive problems. In addition, sleep disturbances in MS seem to coincide with a specific pattern of decreased thalamic FC.Electronic supplementary materialThe online version of this article (doi:10.1007/s00415-016-8318-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

The role of sleep on cognition and functional connectivity in patients with multiple sclerosis

et al. 2016

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“…Moreover, if the subject was too tired during testing, a further session was scheduled to complete the battery within 2 weeks after the first one. Considering that respiratory dysfunction may impact cognitive performances (Kim et al, 2007; Gülhan et al, 2015; Braley et al, 2016), oxygen saturation, and forced vital capacity (FVC) were measured at the time of each examination (i.e., none participant showed oxygen saturation <92 mmHg and FVC < 80%; Montuschi et al, 2015). …”

Section: Methodsmentioning

confidence: 99%

Theory of Mind and Its Neuropsychological and Quality of Life Correlates in the Early Stages of Amyotrophic Lateral Sclerosis

et al. 2016

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This study aims to explore the potential impairment of Theory of Mind (ToM; i.e., the ability to represent cognitive and affective mental states to both self and others) and the clinical, neuropsychological and Quality of Life (QoL) correlates of these cognitive abnormalities in the early stages of amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disease recently recognized as a part of the same clinical and pathological spectrum of frontotemporal lobar degeneration. Twenty-two consecutive, cognitively intact ALS patients, and 15 healthy controls, underwent assessment of executive, verbal comprehension, visuospatial, behavioral, and QoL measures, as well as of the ToM abilities by Emotion Attribution Task (EAT), Advanced Test of ToM (ATT), and Eyes Task (ET). ALS patients obtained significantly lower scores than controls on EAT and ET. No significant difference was found between the two groups on ATT. As regard to type of ALS onset, patients with bulbar onset performed worse than those with spinal onset on ET. Correlation analysis revealed that EAT and ET were positively correlated with education, memory prose, visuo-spatial performances, and “Mental Health” scores among QoL items. Our results suggest that not only “cognitive” but also “affective” subcomponents of ToM may be impaired in the early stages of ALS, with significant linkage to disease onset and dysfunctions of less executively demanding conditions, causing potential impact on patients’ “Mental Health.”

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“…Previous studies have demonstrated that the prevalence and severity of SD are higher in persons with MS 129,130 . Furthermore, it has been demonstrated that among patients with MS, OSA and SD are significantly associated with diminished visual memory, verbal memory, executive function, attention, processing speed, and working memory 131 .…”

Section: Sleep Disordersmentioning

confidence: 99%

Otolaryngologic Symptoms in Multiple Sclerosis: A Review

Ralli¹,

Stadio²,

Visconti³

et al. 2018

The International Tinnitus Journal

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Many symptoms of multiple sclerosis may affect the ear, nose and throat. The most common otolaryngologic symptoms of multiple sclerosis are speech disorders, followed by sleep disorders, vertigo and disequilibrium, dysphagia, smell alterations, and hearing loss. Less common symptoms include sialorrhea, facial palsy, taste alterations, trigeminal neuralgia and tinnitus. The origin of otolaryngologic symptoms in multiple sclerosis is mainly central, although increasing evidence also suggests a peripheral involvement.

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Sleep and Cognitive Function in Multiple Sclerosis

Abstract: A commentary on this article appears in this issue on page 1489.

Cited by 82 publications

References 44 publications

The role of sleep on cognition and functional connectivity in patients with multiple sclerosis

The role of sleep on cognition and functional connectivity in patients with multiple sclerosis

Theory of Mind and Its Neuropsychological and Quality of Life Correlates in the Early Stages of Amyotrophic Lateral Sclerosis

Otolaryngologic Symptoms in Multiple Sclerosis: A Review

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