Sleep and Dream Characteristics in Twins

Gedda, L; Brenci, G.

doi:10.1017/s0001566000009089

Cited by 37 publications

(19 citation statements)

References 3 publications

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“…1), consistent with the influence of multiple, low-penetrance polymorphisms. Accordingly, several older studies reported for sleep duration moderate heritability estimates of 30-40 % [17][18][19].…”

Section: Sleep Durationmentioning

confidence: 99%

Genotype-Dependent Differences in Sleep, Vigilance, and Response to Stimulants

Landolt

2008

CPD

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Abstract:To better understand the neurobiology of sleep disorders, detailed understanding of circadian and homeostatic sleep-wake regulation in healthy volunteers is mandatory. Sleep physiology and the repercussions of experimentallyinduced sleep deprivation on sleep and waking electroencephalogram (EEG), vigilance and subjective state are highly variable, even in healthy individuals. Accumulating evidence suggests that many aspects of normal sleep-wake regulation are at least in part genetically controlled. Current heritability estimates of sleep phenotypes vary between approximately 20-40 % for habitual sleep duration, to over 90 % for the spectral characteristics of the EEG in nonREM sleep. The molecular mechanisms underlying the trait-like, inter-individual variation are virtually unknown, and the human genetics of normal sleep is only at the beginning of being explored. The first studies identified distinct polymorphisms in genes contributing to the endogenous circadian clock and neurochemical systems previously implicated in sleep-wake regulation, to modulate sleep architecture and sleep EEG, vulnerability to sleep loss, and subjective and objective effects of caffeine on sleep. These insights are reviewed here. They disclose molecular mechanisms contributing to normal sleep-wake regulation in humans, and have potentially important implications for the neurobiology of sleep-wake disorders and their pharmacological treatment.

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Section: Sleep Durationmentioning

confidence: 99%

Genotype-Dependent Differences in Sleep, Vigilance, and Response to Stimulants

Landolt

2008

CPD

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“…Так, результаты ряда исследований длительности сна свидетельствуют о том, что влияния об-щей среды на этот признак могут быть особенно выраженными в детстве (напр. : Brescianini et al, 2011;Gedda, Brenci, 1979;Gregory et al, 2006b с противоречащими данными). Заслуживает внимания то обстоятельство, что генетические и средовые влияния на длительность сна изменяются в ходе развития, причем вклад генетических факторов с возрастом увеличи-вается.…”

Section: близнецовые исследования с использованием опросных методикunclassified

Genetic Research on Sleep, Sleep Disturbances and Associated Difficulties

Gregory¹,

Parsons²,

Barclay³

et al. 2016

Behavioural Genetics for Education

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“…27 Individual differences in this program may contribute to the large variation in habitual sleep duration, which shows a perfect normal distribution in the general population. 6,[30][31][32] The Framingham Heart Study 100K Project revealed a linkage peak to usual sleep duration on chromosome 3 including the gene encoding prokineticin 2 (PROK2). Several oldertwin studies and one recent genome-wide association study reported for sleep duration moderate heritability estimates of 17% to 40%.…”

Section: Genes Contributing To Habitual Sleep Durationmentioning

confidence: 99%