Sleep and EEG features in genetic models of Down syndrome

Colas, Damien; Valletta, J; Takimoto-Kimura, Ryoko; Nishino, Seiji; Fujiki, Nobuhiro; Mobley, William C.; Mignot, Emmanuel

doi:10.1016/j.nbd.2007.07.014

Cited by 43 publications

(32 citation statements)

References 39 publications

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“…FoxO6 mutant and wild-type siblings were equipped for frontoparietal and hippocampal EEG recording (Colas et al 2008). Cortical EEG electrodes (0.9 mm diameter) were placed in epidural position over the right hemisphere: frontal, +1.5 mm versus Bregma; parietal, À1.5 mm versus Bregma; both, 1 mm lateral versus midline.…”

Section: In Vivo Cortical and Local Eeg Recordings In Behaving Micementioning

confidence: 99%

FoxO6 regulates memory consolidation and synaptic function

et al. 2012

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The FoxO family of transcription factors is known to slow aging downstream from the insulin/IGF (insulin-like growth factor) signaling pathway. The most recently discovered FoxO isoform in mammals, FoxO6, is highly enriched in the adult hippocampus. However, the importance of FoxO factors in cognition is largely unknown. Here we generated mice lacking FoxO6 and found that these mice display normal learning but impaired memory consolidation in contextual fear conditioning and novel object recognition. Using stereotactic injection of viruses into the hippocampus of adult wild-type mice, we found that FoxO6 activity in the adult hippocampus is required for memory consolidation. Genome-wide approaches revealed that FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus. Consistently, FoxO6 deficiency results in decreased dendritic spine density in hippocampal neurons in vitro and in vivo. Thus, FoxO6 may promote memory consolidation by regulating a program coordinating neuronal connectivity in the hippocampus, which could have important implications for physiological and pathological age-dependent decline in memory.

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Section: In Vivo Cortical and Local Eeg Recordings In Behaving Micementioning

confidence: 99%

FoxO6 regulates memory consolidation and synaptic function

et al. 2012

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“…Functional nests may facilitate sleep (Van de Weerd et al, 1997) and disturbed sleep has been reported for Ts65Dn (Colas et al, 2008). Therefore, we next tested for the effect of circadian phase on nest building by starting the tests at the beginning of the light phase when sleep pressure is high.…”

Section: Nest Building Characterization and Physiological Factors In mentioning

confidence: 99%

“…Ts65Dn mice show DS associated features such as impaired memory processes in relation to abnormal http://dx.doi.org/10.1016/j.nlm.2014.10.002 1074-7427/Ó 2014 Elsevier Inc. All rights reserved. synaptic plasticity, sleep disturbances, and stereotypy (Colas et al, 2008;Kleschevnikov et al, 2004;Seregaza, Roubertoux, Jamon, & Soumireu-Mourat, 2006;Turner et al, 2001). Mouse models of chromosome 21 triplication have provided insights into genetic contributions to specific DS traits in relation to the gene-dosage or genetic network theories (Gardiner et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors

Heller

Salehi

Chuluun

et al. 2014

Neurobiology of Learning and Memory

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“…Implantation of EEG/EMG electrodes was done as previously described [3,39]. EEG electrodes were placed over the frontal and parietal cortex.…”

Section: Methodsmentioning

confidence: 99%

Loss of Melanopsin Photoreception and Antagonism of the Histamine H3 Receptor by Ciproxifan Inhibit Light-Induced Sleep in Mice

et al. 2015

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Light has direct effects on sleep and wakefulness causing arousal in diurnal animals and sleep in nocturnal animals. In the present study, we assessed the modulation of light-induced sleep by melanopsin and the histaminergic system by exposing mice to millisecond light flashes and continuous light respectively. First, we show that the induction of sleep by millisecond light flashes is dose dependent as a function of light flash number. We found that exposure to 60 flashes of light occurring once every 60 seconds for 1-h (120-ms of total light over an hour) induced a similar amount of sleep as a continuous bright light pulse. Secondly, the induction of sleep by millisecond light flashes was attenuated in the absence of melanopsin when animals were presented with flashes occurring every 60 seconds over a 3-h period beginning at ZT13. Lastly, the acute administration of a histamine H3 autoreceptor antagonist, ciproxifan, blocked the induction of sleep by a 1-h continuous light pulse during the dark period. Ciproxifan caused a decrease in NREMS delta power and an increase in theta activity during both sleep and wake periods respectively. The data suggest that some form of temporal integration occurs in response to millisecond light flashes, and that this process requires melanopsin photoreception. Furthermore, the pharmacological data suggest that the increase of histaminergic neurotransmission is sufficient to attenuate the light-induced sleep response during the dark period.

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Sleep and EEG features in genetic models of Down syndrome

Cited by 43 publications

References 39 publications

FoxO6 regulates memory consolidation and synaptic function

FoxO6 regulates memory consolidation and synaptic function

Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors

Loss of Melanopsin Photoreception and Antagonism of the Histamine H3 Receptor by Ciproxifan Inhibit Light-Induced Sleep in Mice

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