Sleep and Fatigue in Cancer Patients

Ancoli‐Israel, Sonia

doi:10.1016/b0-72-160797-7/50110-5

Cited by 9 publications

(3 citation statements)

References 48 publications

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“…Given already existing reviews and literature on meta-analyses of the non-pharmacological [36–38] and pharmacological treatment of fatigue in patients with cancer, [39,40] this article will focus primarily on studies that have examined the effect of non-pharmacological and pharmacological sleep interventions on associated fatigue symptoms and insomnia. In addition, pharmacological interventions for insomnia as a whole in patients with cancer will be reviewed as, despite the widespread use of hypnotic agents (such as benzodiazepines, non-benzodiazepine hypnotic agents, sedating anti-depressants, anti-histamines, neuroleptics and chloral hydrate) in palliative care practice, [41] it is surprising that there have been no large scale randomized controlled trials of hypnotic medications in patients with cancer and insomnia.…”

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confidence: 99%

Does Effective Management of Sleep Disorders Reduce Cancer-Related Fatigue?

Zee

Ancoli‐Israel

2009

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Cancer and cancer therapy are often associated with symptoms such as fatigue and sleep disturbances, before, during and after therapy. These symptoms of fatigue and poor sleep often occur in parallel having a significant impact on the physical functioning of patients with cancer. A strong correlation between cancer-related fatigue (CRF) and sleep has been observed in several studies, suggesting that they may be reciprocally related. The co-clustering of these symptoms suggests that they may have similar underlying aetiology and that treatments targeting either symptom may positively affect the other. Studies examining these clusters have shown that these symptoms often co-vary together. The potential mechanisms that link the relationship between insomnia and CRF are intriguing but require further investigation. Despite the high prevalence of insomnia and the often bidirectional relationship between poor sleep and fatigue, there are limited data to support the use of sleep management interventions as a means to reduce fatigue in patients with cancer. Assessment of the available evidence across trials is complicated by different study designs, patient selection criteria, stage of cancer treatment and by the nature of the interventions studied. Improvements from baseline in both sleep parameters and CRF have been documented in a limited number of studies, including two randomized-controlled trials using cognitive behavioural therapy for insomnia (CBT-I). In contrast, the efficacy of pharmacological therapies in reducing both insomnia and CRF is largely lacking. Clearly, treating clinically significant insomnia is likely to have benefits for the patient with cancer and for those who are recovering from cancer. In particular, pharmacotherapies for insomnia, singly or in combination with CBT-I, should be evaluated in multicentre randomized clinical trials to examine their efficacy in improving sleep quality and reducing associated CRF.

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Section: Introductionmentioning

confidence: 99%

Does Effective Management of Sleep Disorders Reduce Cancer-Related Fatigue?

Zee

Ancoli‐Israel

2009

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“…1 Few researchers have examined sleep-wake disturbances in patients with cancer as a primary variable; even still, much of the evidence has emerged from research focusing on symptoms and QOL. 1 Few researchers have examined sleep-wake disturbances in patients with cancer as a primary variable; even still, much of the evidence has emerged from research focusing on symptoms and QOL.…”

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Sleeping With the Enemy

et al. 2015

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“…Cognitive consequences of decreased TST include sleepiness (inability to maintain the awake state (Wolfson & Carskadon, 1998). Fatigue (mental or physical exhaustion) may occur in response to decreased TST, but the relationship of fatigue to daytime sleepiness and TST is unclear (Ancoli‐Israel, 2005). Both sleepiness and fatigue may decrease the motivation to maintain a healthy balance between energy consumption and expenditure.…”

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confidence: 99%