Sleep and frailty risk: a systematic review and meta-analysis

Pourmotabbed, Ali; Boozari, Behnoosh; Babaei, Atefeh; Asbaghi, Omid; Campbell, Marilyn S.; Mohammadi, Hamed; Hadi, Amir; Moradi, Sajjad

doi:10.1007/s11325-020-02061-w

Cited by 60 publications

(63 citation statements)

References 47 publications

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“…Importantly, sleep quality contributed even more than physical fitness to explaining the variability of frailty in the young old women, and it was also a significant contributor to explaining the variability of frailty in the old women. This finding supports the limited, although consistent, evidence on the relationship between sleep quality and frailty [e.g., (12,13)]. Furthermore, our findings also support the literature reporting the modifying effect of gender on the association between sleep disturbances and frailty.…”

Section: Discussionsupporting

confidence: 91%

“…It appears that the association between sleep disturbances and frailty only exists among female older adults (12). However, another review focusing on sleep durations reported no gender differences in the association between longer and shorter sleep durations and the increased risk of frailty (13). Further research is needed to explore the impact of sleep disturbances and quality (insomnia symptoms, excessive daytime sleepiness and sleep-wake patterns) on frailty in women as well as in men in early stages of frailty, possibly incorporating assessments and interventions for improving sleep quality in this group.…”

Section: Discussionmentioning

confidence: 99%

“…One reported a consistent relationship between frailty and sleep disturbances, although the review was based on limited research (12). The other focused on sleep duration, suggesting that while shorter sleep duration (under 6 h) was associated with risk of frailty, prolonged sleep time (more than 8 h) was significantly related to enhanced risk of pre-frailty (13).…”

Section: Introductionmentioning

confidence: 99%

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Correlates of Early-Stage Frailty—Sleep, Fitness, Oxidative Stress, and BMI

et al. 2021

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Frailty reflects a decreased reserve in multiple systems resulting from cumulative decline. Frailty markers should be identified as early as possible to attenuate the loss of reserve. The aim of this study was to identify potentially modifiable correlates of frailty in relatively healthy older adults. Volunteers (n = 122) were recruited from local councils and, based on gender and age, were divided into one group of men aged 77.0 (±5.3), and two groups of women, aged 68.8 (±3.6) and aged 78.4 (±3.4). Frailty was assessed by a Frailty Index. The examined correlates were: physical activity, physical fitness (predicted peak VO2), sleep quality, oxidative stress (hydrogen peroxide—H2O2) and depression. Both groups of women had poor scores on physical fitness compared to women's norms. In order to examine the contribution of each of the potential correlates to explaining the variance of frailty, stepwise regressions were performed for each group separately. Based on the results, none of the suggested correlates significantly explained the variability of frailty in the men. In the younger-aged women, predicted peak VO2 and sleep quality explained 22.4% of the variability of frailty. In the older women, Body Mass Index (BMI), oxidative stress and sleep quality explained 34.9% of the variance. It is possible that increased aerobic fitness and interventions for improving sleep quality in older, seemingly healthy women will slow down the frailty process. Further research is needed to assess potential correlates of frailty, and to initiate suitable interventions to mitigate the signs of frailty at an early stage.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlates of Early-Stage Frailty—Sleep, Fitness, Oxidative Stress, and BMI

et al. 2021

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“…The comorbidity of CSVD and a sleep disorder might be related to chronic inflammation, oxidative stress, and other common pathways ( Wang et al, 2020a , b ). Further, several studies have demonstrated that people with poor sleep quality have increased odds of frailty ( Pourmotabbed et al, 2020 ; Shih et al, 2020 ). A longitudinal study revealed that people with sleep disturbance at the baseline had a higher risk of frailty during the follow-up period ( Ensrud et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Zhao

Zhou

et al. 2021

Front. Aging Neurosci.

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Background: Physical frailty is a common problem among older adults which usually leads to adverse health outcomes. The imaging markers of cerebral small vessel disease (CSVD) are associated with frailty, but the underlying mechanisms remain unclear. The present study aimed to investigate the mediating role of sleep quality in the relationship between CSVD burden and frailty.Methods: We performed a cross-sectional study and enrolled community residents. Frailty and sleep quality were measured using the Fried frailty phenotype and the Pittsburgh Sleep Quality Index (PSQI), respectively. A multivariate linear regression analysis and a Bootstrap analysis were performed to examine the association among the key variables and the mediating role of sleep quality.Results: Of the 726 participants (mean age: 65.5 ± 6.5 years, 59.8% female), the numbers (percentages) of the frail, prefrail, and robust residents were 49 (6.7%), 310 (42.7%), and 367 (50.6%), respectively. After adjusting for covariates, the CSVD burden and PSQI score were significantly associated with the frailty score. In addition, sleep quality played a partial mediating role in the association between CSVD burden and physical frailty. The mediating effect was 21.9%.Conclusion: The present study suggests that sleep quality is a mediator of this association between CSVD and frailty in community-dwelling older adults. Improving sleep quality might be helpful to mitigate the risk of frailty in CSVD patients.

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“…Physical functions such as grip strength and gait speed are also included in the sarcopenia diagnostic criteria. Similar to the relationship between sleep duration and sarcopenia, shorter (<6 h) and longer (>8 h) sleep duration significantly increased the risk of frailty (Pourmotabbed et al, 2020). Additionally, the risk of frailty is increased by other sleep parameters such as daytime sleepiness, sleep-disordered breathing, and prolonged sleep latency (Endeshaw et al, 2009;Ensrud et al, 2009Ensrud et al, , 2012Vaz Fragoso et al, 2009;Nakakubo et al, 2019).…”

Section: Circadian Rhythm and Sarcopenia Human Studymentioning

confidence: 73%

Chrono-Nutrition Has Potential in Preventing Age-Related Muscle Loss and Dysfunction

2021

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The mammalian circadian clock systems regulate the day–night variation of several physiological functions such as the sleep/wake cycle and core body temperature. Disturbance in the circadian clock due to shiftwork and chronic jetlag is related to the risk of several disorders such as metabolic syndrome and cancer. Recently, it has been thought that shiftwork increases the risk of sarcopenia which is characterized by age-related decline of muscle mass and its dysfunctions including muscle strength and/or physical performance. First, we summarize the association between circadian rhythm and the occurrence of sarcopenia and discuss its mechanistic insight by focusing on the muscle function and molecular clock gene in knockout or mutant mice. The clock gene knockout or mutant mice showed early aging phenotypes, including low survival rate and muscle loss. It suggests that improvement in the disturbance of the circadian clock plays an important role in the aging process of healthy muscles. Nutritional intake has the potential to augment muscle growth and entrain the peripheral clock. Second, we discuss the potential of chrono-nutrition in preventing aging-related muscle loss and dysfunction. We also focus on the effects of time-restricted feeding (TRF) and the distribution of protein intake across three meals.

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Sleep and frailty risk: a systematic review and meta-analysis

Cited by 60 publications

References 47 publications

Correlates of Early-Stage Frailty—Sleep, Fitness, Oxidative Stress, and BMI

Correlates of Early-Stage Frailty—Sleep, Fitness, Oxidative Stress, and BMI

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Chrono-Nutrition Has Potential in Preventing Age-Related Muscle Loss and Dysfunction

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