Sleep and Long COVID—A Review and Exploration of Sleep Disturbances in Post Acute Sequelae of SARS-COV-2 (PASC) and Therapeutic Possibilities

Lee, Elliott K; Auger, R. Robert

doi:10.1007/s40675-024-00299-4

Curr Sleep Medicine Rep

2024

DOI: 10.1007/s40675-024-00299-4

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Sleep and Long COVID—A Review and Exploration of Sleep Disturbances in Post Acute Sequelae of SARS-COV-2 (PASC) and Therapeutic Possibilities

Elliott K Lee,

R. Robert Auger

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2024

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Cited by 2 publications

References 111 publications

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Resting-state functional connectome predicts sleep quality two months after the first negative COVID-19 antigen test

Jin,

Chen,

et al. 2024

Sleep Medicine

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Resting-state functional connectome predicts sleep quality two months after the first negative COVID-19 antigen test

Jin,

Chen,

et al. 2024

Sleep Medicine

View full text Add to dashboard Cite

Pathophysiological, Neuropsychological, and Psychosocial Influences on Neurological and Neuropsychiatric Symptoms of Post-Acute COVID-19 Syndrome: Impacts on Recovery and Symptom Persistence

Malioukis,

Snead,

Marczika

et al. 2024

Biomedicines

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Although the impact of post-acute COVID-19 syndrome (PACS) on patients and public health is undeniably significant, its etiology remains largely unclear. Much research has been conducted on the pathophysiology, shedding light on various aspects; however, due to the multitude of symptoms and clinical conditions that directly or indirectly define PACS, it is challenging to establish definitive causations. In this exploration, through systematically reviewing the latest pathophysiological findings related to the neurological symptoms of the syndrome, we aim to examine how psychosocial and neuropsychological symptoms may overlap with neurological ones, and how they may not only serve as risk factors but also contribute to the persistence of some primary symptoms of the disorder. Findings from our synthesis suggest that psychological and psychosocial factors, such as anxiety, depression, and loneliness, may interact with neurological symptoms in a self-reinforcing feedback loop. This cycle seems to be affecting both physical and psychological distress, potentially increasing the persistence and severity of PACS symptoms. By pointing out this interaction, in this review study, we attempt to offer a new perspective on the interconnected nature of psychological, psychosocial, and neurological factors, emphasizing the importance of integrated treatment approaches to disrupt this cycle and improve outcomes when possible.

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Sleep and Long COVID—A Review and Exploration of Sleep Disturbances in Post Acute Sequelae of SARS-COV-2 (PASC) and Therapeutic Possibilities

Cited by 2 publications

References 111 publications

Resting-state functional connectome predicts sleep quality two months after the first negative COVID-19 antigen test

Resting-state functional connectome predicts sleep quality two months after the first negative COVID-19 antigen test

Pathophysiological, Neuropsychological, and Psychosocial Influences on Neurological and Neuropsychiatric Symptoms of Post-Acute COVID-19 Syndrome: Impacts on Recovery and Symptom Persistence

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