2023
DOI: 10.1111/jnc.15787
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Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain

Abstract: In countries around the world, sleep deprivation represents a widespread problem affecting school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep restriction adversely affect individual health, impairing memory and cognitive performance as well as increasing the risk and progression of numerous diseases. In mammals, the hippocampus and hippocampus‐dependent memory are vulnerable to the effects of acute sleep deprivation. Sleep deprivation induces changes in molecular signali… Show more

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Cited by 19 publications
(5 citation statements)
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References 240 publications
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“…A further interesting point concerns the observation that sleep deprivation can alter hippocampus-dependent memory by causing alterations at the level of gene transcription, but also by affecting mRNA translation into proteins (for a recent review, see Ref. [ 249 ]).…”
Section: Post-transcriptional Regulation and Synaptic Plasticity In T...mentioning
confidence: 99%
“…A further interesting point concerns the observation that sleep deprivation can alter hippocampus-dependent memory by causing alterations at the level of gene transcription, but also by affecting mRNA translation into proteins (for a recent review, see Ref. [ 249 ]).…”
Section: Post-transcriptional Regulation and Synaptic Plasticity In T...mentioning
confidence: 99%
“…In addition, synapses and neurons are critical for signaling between neurons and maintaining cognitive function [49,50]. Insufficient sleep causes modifications in molecular signaling and gene expression and potentially results in alterations to the synaptic structure of neurons [51]. Patients with OSA may have abnormal regulation of synaptic transmission, which may lead to signaling problems between neurons, affecting cognitive and emotional regulation [52].…”
Section: Gene Enrichment Analysismentioning
confidence: 99%
“…[1] In modern society, lack of sleep, defined as getting less than six hours of sleep a night, is common in all countries. [2,3] The "sleep debt" caused by chronic sleep deprivation (SD) can be more harmful than people think. [4] SD can cause depression, fear, and other negative emotions, [5,6] reduce movement and balance skills, [7,8] cause memory and cognitive impairments, [9][10][11] increase food attraction and cause obesity, [12,13] diabetes, [14] cardiovascular diseases, cerebrovascular diseases, [15][16][17] and bone diseases, [18] interfere with immune function, [19,20] and cause an increased risk of cancer, [21] and death.…”
Section: Introductionmentioning
confidence: 99%