Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship

Babiloni, Alberto Herrero; Koninck, Béatrice P. De; Beetz, Gabrielle; Martel, Marc O.; Lavigne, Gilles

doi:10.1007/s00702-019-02067-z

Cited by 136 publications

(114 citation statements)

References 158 publications

Supporting

Mentioning

111

Contrasting

Order By: Relevance

“…Lower melatonin levels are also associated with an increased delirium risk. It may seem obvious that pain disrupts sleep, but there is also an increasing body of evidence suggesting that sleep deprivation induces a hyper-algesic response [19]. Inflammation and, particularly, pro-inflammatory cytokines are key potential mediators of this association.…”

Section: Understanding Cause and Effectmentioning

confidence: 99%

Pain and delirium: mechanisms, assessment, and management

2020

View full text Add to dashboard Cite

Aim To provide a clinical overview of the association between pain and delirium, the mechanisms which may underlie this and how pain can be detected and managed in delirium. Findings There are few studies in this field. It is likely that pain is a key cause of delirium but this relationship is complex and mediated by many factors. Observational tools may help diagnose pain in delirium but need further testing. Message Pain is a potentially treatable cause of delirium and future research in how to better detect and managed this is required.

show abstract

Section: Understanding Cause and Effectmentioning

confidence: 99%

Pain and delirium: mechanisms, assessment, and management

2020

View full text Add to dashboard Cite

show abstract

“…For example, a recent meta-analysis with pooled estimates from 37 studies using polysomonography in populations with persistent pain, reported a 72% prevalence of insomnia [18]. This interrelation between sleep and pain is echoed in recent reviews [8,13,19], which, in contrast to previous studies investigating (bi)directionality, highlights a more consistent unidirectional effect of poor sleep on pain exacerbation and vulnerability.…”

Section: Introductionmentioning

confidence: 97%

“…Sleep constitutes an equally complex and vital biological function, with the behaviorally-driven goal to maintain homeostasis across multiple physiological systems: It is essential for recuperation of physical and psychological stressors, learning, physical performance, cognition, emotional modulation, brain plasticity memory encoding, and consolidation, as well as overall health of the mammalian organism [1][2][3][4]. Furthermore, poor sleep poses a well-known and potent risk factor for a multitude of physical and physiological ailments, including obesity, dementia, diabetes, widespread and chronic pain, as well as all-cause mortality [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…In mechanical, interventional and epidemiological studies alike, considerable effort has been devoted to progressively shed light on the relationship between sleep and pain [8,[11][12][13][14][15][16][17]. For example, a recent meta-analysis with pooled estimates from 37 studies using polysomonography in populations with persistent pain, reported a 72% prevalence of insomnia [18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Poor Sleep Is a Risk Factor for Low-Back Pain among Healthcare Workers: Prospective Cohort Study

Vinstrup

Jakobsen

Andersen

2020

IJERPH

View full text Add to dashboard Cite

This study aimed to investigate the association between poor sleep and risk of low-back pain (LBP) in healthcare workers. Using a prospective cohort design with 1-year follow-up, a total of 1955 healthcare workers (60% nurses) from 389 departments at 19 hospitals responded to questionnaires containing items related to lifestyle, health, and working environment. Associations between sleep scores (0–100) at baseline and LBP intensity (0–10) at follow-up were modelled using cumulative logistic regression accounting for clustering at the department level and adjusted for lifestyle and psychosocial confounders. In the full population of healthcare workers, 43.9% and 24.4% experienced moderate and poor sleep, respectively. In the fully adjusted model with good sleep as reference, moderate, and poor sleep increased the risk of LBP at follow-up, with odds ratios (OR’s) of 1.66 (95% confidence interval (CI) 1.35–2.04) and 2.05 (95% CI 1.57–2.69), respectively. Three sensitivity analyses including healthcare workers free from LBP, nurses, and nurses free from LBP at baseline, respectively, yielded similar results. In conclusion, poor sleep constitutes a potent risk factor for LBP among healthcare workers. The presented results provide strong incentives to evaluate and weigh current prevention policies against an updated biopsychosocial framework.

show abstract

“…Numerous cross-sectional studies show that there is a high degree of comorbidity between chronic pain and other pathological conditions, such as sleep and affective disorders. Herrero Babiloni et al (2020) discuss the direction of the relationship between chronic pain and sleep disorders in adult and pediatric populations. They also summarize the putative factors influencing the interactions, such as endogenous pain modulation, inflammation, affects, mood, and cyclic alternating patterns of endogenous substance production.…”

mentioning

confidence: 99%

Advances in the understanding and treatment of pain and headache

Dallel

2020

J Neural Transm

View full text Add to dashboard Cite

Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship

Cited by 136 publications

References 158 publications

Pain and delirium: mechanisms, assessment, and management

Pain and delirium: mechanisms, assessment, and management

Poor Sleep Is a Risk Factor for Low-Back Pain among Healthcare Workers: Prospective Cohort Study

Advances in the understanding and treatment of pain and headache

Contact Info

Product

Resources

About