Sleep and psychiatric diseases

Rotenberg, Vadim S.

doi:10.1016/b978-0-444-52006-7.00036-8

Cited by 2 publications

(1 citation statement)

References 150 publications

(119 reference statements)

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“…Furthermore, patients with NF1 have a higher incidence of psychiatric disorders, especially depression and anxiety [Mouridsen and Sorensen, ; Zoller and Rembeck, ], and indeed reduced sleep has been described in NF1, associated with mental illness [Samuelsson and Riccardi, ]. Both psychiatric disorders and medications used in their treatment may have a serious impact on sleep quality and disturbance [Rotenberg, ]. Intriguingly, null mutations of nf1 in Drosophila result in abnormalities of circadian rhythm in locomotor activity and altered oscillations and levels of a circadian clock output protein [Williams et al, ].…”

Section: Introductionmentioning

confidence: 99%

Sleep disturbance as part of the neurofibromatosis type 1 phenotype in adults

Leschziner

Golding

Ferner

2013

American J of Med Genetics Pt A

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Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a wide array of neurological complications, including cognitive dysfunction, tumors, malformations, neuropathy, neurovascular disease, and epilepsy. Many of these complications may impact on sleep quality and cause sleep disturbance. Previously sleep disturbance in NF1 has been specifically addressed solely in children. We performed a prospective study of sleep quality in 114 consecutive out-patients with NF1 attending our national neurofibromatosis service. The Epworth sleepiness scale (ESS) and the Pittsburgh sleep quality index (PSQI) were administered, and information was obtained from patient records on drugs potentially impacting on sleep, complications directly affecting sleep and employment status. The mean ESS was 6.8, and 21% had an abnormally high ESS of 10 or more. The mean global PSQI score was 8.4 (norm mean 2.67), with abnormally high scores in all sleep domains. Thirty-nine patients had a bed partner and 54% reported features suggestive of periodic limb movements of sleep, 43% had features suggestive of obstructive sleep apnoea, and 10.8% experienced confusion on waking. There was no evidence of phase shift. The ESS did not correlate with the PSQI, but unemployment status was associated with worse global PSQI score and multiple domain sub-scales of sleep quality in the PSQI. We conclude that sleep disturbance and poor sleep quality are significantly more frequent in the adult NF1 patient population. It is likely to be multi-factorial, related to pain, anxiety, depression, cognitive issues, and organic sleep pathology. We recommend careful assessment of patients to determine underlying triggers and possible treatment strategies.

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Section: Introductionmentioning

confidence: 99%