Sleep and sleep disordered breathing in children with down syndrome: Effects on behaviour, neurocognition and the cardiovascular system

Horne, Rosemary Sylvia Claire; Wijayaratne, Poornima R.; Nixon, Gillian M.; Walter, Lisa M.

doi:10.1016/j.smrv.2018.11.002

Cited by 72 publications

(38 citation statements)

References 96 publications

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“…More generally, a meta-analysis indicated that TD children with SRBD have more attention deficit/hyperactivity symptomatology than do TD children who do not have SRBD [37]. Similar results have been reported for children with Down syndrome who have SRBD [38].…”

Section: Association Of Child Sleep Characteristics and Problems To Lsupporting

confidence: 63%

Sleep Characteristics and Problems of 2-year-olds with Williams Syndrome: Relations with Language and Behavior

Magalhães

O’Brien

Mervis

2020

Preprint

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Background Sleep problems have been shown to have a negative impact on language development and behavior for both typically developing children and children with a range of neurodevelopmental disorders. The relation of sleep characteristics and problems to language and behavior for children with Williams syndrome (WS) is unclear. The goal of this study was to address these relations for 2-year-olds with WS. Associations of nonverbal reasoning ability, nighttime sleep duration, and excessive daytime sleepiness with language ability and behavior problems were considered. Method: Ninety-six 2-year-olds with genetically confirmed classic-length WS deletions participated. Parents completed the Pediatric Sleep Questionnaire, which includes a Sleep Related Breathing Disorder (SRBD) scale with a subscale measuring excessive daytime sleepiness, to assess sleep characteristics and problems. Parents also completed the Child Behavior Checklist (CBCL) and the MacArthur-Bates Communicative Development Inventory: Words and Sentences to assess behavior problems and expressive vocabulary, respectively. Children completed the Mullen Scales of Early Learning to measure nonverbal reasoning and language abilities. Results Parents indicated that children slept an average of 10.36 hours per night (SD = 1.09, range: 7.3–13.3), not differing significantly from the mean reported by Bell and Zimmerman (2010) for typically developing toddlers (p = .787). Sixteen percent of participants screened positive for SRBD and 30% for excessive daytime sleepiness. Children who screened positive for SRBD had significantly more behavior problems on all CBCL scales than children who screened negative. Children with daytime sleepiness had significantly more attention/hyperactivity, stress, and externalizing problems than those who did not have daytime sleepiness. Individual differences in parent-reported nighttime sleep duration and directly measured nonverbal reasoning abilities accounted for unique variance in expressive language, receptive language, and internalizing problems. Individual differences in parent-reported daytime sleepiness accounted for unique variance in externalizing problems. Conclusions The relations of nighttime sleep duration, positive screens for SRBD, and excessive daytime sleepiness to language and behavior in toddlers with WS parallel prior findings for typically developing toddlers. These results highlight the importance of screening young children with WS for sleep problems. Studies investigating the efficacy of behavioral strategies for improving sleep in children with WS are warranted.

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Section: Association Of Child Sleep Characteristics and Problems To Lsupporting

confidence: 63%

Sleep Characteristics and Problems of 2-year-olds with Williams Syndrome: Relations with Language and Behavior

Magalhães

O’Brien

Mervis

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…More generally, a meta-analysis indicated that TD children with SRBD have more attention de cit/hyperactivity symptomatology than do TD children who do not have SRBD [39]. Similar results have been reported for children with Down syndrome who have SRBD [40].…”

Section: Association Of Child Sleep Characteristics and Problems To Lsupporting

confidence: 62%

Sleep Characteristics and Problems of 2-year-olds with Williams Syndrome: Relations with Language and Behavior

Magalhães

O’Brien

Mervis

2020

Preprint

View full text Add to dashboard Cite

Background: Sleep problems have been shown to have a negative impact on language development and behavior for both typically developing children and children with a range of neurodevelopmental disorders. The relation of sleep characteristics and problems to language and behavior for children with Williams syndrome (WS) is unclear. The goal of this study was to address these relations for 2-year-olds with WS. Associations of nonverbal reasoning ability, nighttime sleep duration, and excessive daytime sleepiness with language ability and behavior problems were considered. Method: Ninety-six 2-year-olds with genetically confirmed classic-length WS deletions participated. Parents completed the Pediatric Sleep Questionnaire, which includes a Sleep Related Breathing Disorder (SRBD) scale with a subscale measuring excessive daytime sleepiness, to assess sleep characteristics and problems. Parents also completed the Child Behavior Checklist (CBCL) and the MacArthur-Bates Communicative Development Inventory: Words and Sentences to assess behavior problems and expressive vocabulary, respectively. Children completed the Mullen Scales of Early Learning to measure nonverbal reasoning and language abilities. Results: Parents indicated that children slept an average of 10.36 hours per night (SD = 1.09, range: 7.3–13.3), not differing significantly from the mean reported by Bell and Zimmerman (2010) for typically developing toddlers (p = .787). Sixteen percent of participants screened positive for SRBD and 30% for excessive daytime sleepiness. Children who screened positive for SRBD had significantly more behavior problems on all CBCL scales than children who screened negative. Children with excessive daytime sleepiness had significantly more attention/hyperactivity, stress, and externalizing problems than those who did not have daytime sleepiness. Individual differences in parent-reported nighttime sleep duration and directly measured nonverbal reasoning abilities accounted for unique variance in expressive language, receptive language, and internalizing problems. Individual differences in parent-reported daytime sleepiness accounted for unique variance in externalizing problems.Conclusions: The relations of nighttime sleep duration, positive screens for SRBD, and excessive daytime sleepiness to language and behavior in toddlers with WS parallel prior findings for typically developing toddlers. These results highlight the importance of screening young children with WS for sleep problems. Studies investigating the efficacy of behavioral strategies for improving sleep in children with WS are warranted.

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“…Moreover, the location of the upper airway stenosis is similar to the results of many previous studies 19,20 . Previous research has confirmed that OSHAS is highly correlated with the occurrence and development of hypertension and vascular endothelial function injury 21,22 . However, the effect of HIF-1α expression on cardiovascular function in patients with OSHAS is still controversial.…”

Section: Discussionmentioning

confidence: 79%

Effect of mandibular advancement device treatment on HIF-1α, EPO and VEGF in the myocardium of obstructive sleep apnea–hypopnea syndrome rabbits

Zhu

Kang

Zhang

et al. 2020

Sci Rep

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All methods in this study were performed in accordance with the medical ethics committee in Hospital of Stomatology, Hebei Medical University. Animal use and care was in accordance with the guidelines of the medical ethics committee for the housing and care of animals bred, supplied and used for scientific purposes. All experiments were performed in accordance with relevant guidelines and regulations. The work was approved by the medical ethics committee in Hospital of Stomatology, Hebei Medical University (Certificate No. [2017]016). Animal model development. Every effort was made to minimize animal pain and suffering. A total of 18 male 6-month-old New Zealand white rabbits (initial weight, 3-3.5 kg) were randomly divided into three groups: the OSHAS, MAD, and control groups, with 6 rabbits in each group. All of the animals were housed under normal laboratory conditions. Food and water were available ad libitum. The animal models were developed in the same way as in our previous studies 12,13. Briefly, OSAHS was induced via injection of gel into the submucous muscular layer in the centre of the soft palate 1.5 cm away from the junction of the soft and hard palate (Fig. 1). No gel was injected in the control group. Animals in these two groups were later confirmed to have OSAHS by clinical signs, CBCT scanning and polysomnography (PSG).

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Sleep and sleep disordered breathing in children with down syndrome: Effects on behaviour, neurocognition and the cardiovascular system

Cited by 72 publications

References 96 publications

Sleep Characteristics and Problems of 2-year-olds with Williams Syndrome: Relations with Language and Behavior

Sleep Characteristics and Problems of 2-year-olds with Williams Syndrome: Relations with Language and Behavior

Sleep Characteristics and Problems of 2-year-olds with Williams Syndrome: Relations with Language and Behavior

Effect of mandibular advancement device treatment on HIF-1α, EPO and VEGF in the myocardium of obstructive sleep apnea–hypopnea syndrome rabbits

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