Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration

Tononi, Giulio; Cirelli, Chiara

doi:10.1016/j.neuron.2013.12.025

Cited by 1,803 publications

(1,768 citation statements)

References 245 publications

(368 reference statements)

Supporting

Mentioning

1,644

Contrasting

Unclassified

Order By: Relevance

“…Particularly, the concept of synaptic down‐scaling states that synapses that are activated strongly (i.e. those corresponding to prioritized content in the present study) are relatively preserved, whereas those less activated are downscaled and eventually forgotten (Nere et al ., 2013; Tononi and Cirelli, 2014); indeed, there was faster forgetting of nHL relative to HL content (Fig. 2).…”

Section: Discussionmentioning

confidence: 77%

Sleep restriction can attenuate prioritization benefits on declarative memory consolidation

Bennion

Chee

2016

Journal of Sleep Research

View full text Add to dashboard Cite

SummaryAs chronic sleep restriction is a widespread problem among adolescents, the present study investigated the effects of a 1‐week sleep restriction (SR) versus control period on the consolidation of long‐term memory for prose passages. We also determined whether the benefit of prioritization on memory is modulated by adequate sleep occurring during consolidation. Fifty‐six healthy adolescents (25 male, aged 15–19 years) were instructed to remember a prose passage in which half of the content was highlighted (prioritized), and were told that they would receive an additional bonus for remembering highlighted content. Following an initial free recall test, participants underwent a 7‐night period in which they received either a 5‐h (SR) or 9‐h (control) nightly sleep opportunity, monitored by polysomnography on selected nights. Free recall of the passage was tested at the end of the sleep manipulation period (1 week after encoding), and again 6 weeks after encoding. Recall of highlighted content was superior to that of non‐highlighted content at all three time‐points (initial, 1 week, 6 weeks). This beneficial effect of prioritization on memory was stronger 1 week relative to a few minutes after encoding for the control, but not the SR group. N3 duration was similar in the control and SR groups. Overall, the present study shows that the benefits of prioritization on memory are enhanced over time, requiring time and sleep to unfold fully. Partial sleep deprivation (i.e. 5‐h nocturnal sleep opportunity) may attenuate such benefits, but this may be offset by preservation of N3 sleep duration.

show abstract

Section: Discussionmentioning

confidence: 77%

Sleep restriction can attenuate prioritization benefits on declarative memory consolidation

Bennion

Chee

2016

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

“…This is an intriguing finding, as one would expect the greater sleep deficits to lead to greater sleep propensity. Healthy aging is associated with a reduction in daytime sleep propensity, sleep continuity, and SWS and may reflect a lessening in homeostatic sleep requirement,66 which is related to synaptic strength and plasticity 67. Therefore, there may be a complex mechanistic link between the progressive decrease in daytime sleepiness and increasing sleep deficits in HD involving a gradually worsening synaptic pathology, which may also account for some of the early cognitive deficits.…”

Section: Discussionmentioning

confidence: 99%

Sleep deficits but no metabolic deficits in premanifest Huntington's disease

Lázár

Panin

Goodman

et al. 2015

Annals of Neurology

105

107

View full text Add to dashboard Cite

ObjectiveHuntington disease (HD) is a fatal autosomal dominant, neurodegenerative condition characterized by progressively worsening motor and nonmotor problems including cognitive and neuropsychiatric disturbances, along with sleep abnormalities and weight loss. However, it is not known whether sleep disturbances and metabolic abnormalities underlying the weight loss are present at a premanifest stage.MethodsWe performed a comprehensive sleep and metabolic study in 38 premanifest gene carrier individuals and 36 age‐ and sex‐matched controls. The study consisted of 2 weeks of actigraphy at home, 2 nights of polysomnography and multiple sleep latency tests in the laboratory, and body composition assessment using dual energy x‐ray absorptiometry scanning with energy expenditure measured over 10 days at home by doubly labeled water and for 36 hours in the laboratory by indirect calorimetry along with detailed cognitive and clinical assessments. We performed a principal component analyses across all measures within each studied domain.ResultsCompared to controls, premanifest gene carriers had more disrupted sleep, which was best characterized by a fragmented sleep profile. These abnormalities, as well as a theta power (4–7Hz) decrease in rapid eye movement sleep, were associated with disease burden score. Objectively measured sleep problems coincided with the development of cognitive, affective, and subtle motor deficits and were not associated with any metabolic alterations.InterpretationThe results show that among the earliest abnormalities in premanifest HD is sleep disturbances. This raises questions as to where the pathology in HD begins and also whether it could drive some of the early features and even possibly the pathology. Ann Neurol 2015;78:630–648

show abstract

“…It is possible that in the immediate aftermath of learning, this connection is active while undertaking the task using visuo-spatial imagery, but not successfully tuned to performance (as the 30min group is at chance level). In the 24hr group, the connection has been modified by consolidation processes during SWS such that more SWS has strengthened the connection through reactivation (Born and Wilhelm 2012), while insufficient SWS has failed to counteract the effects of synaptic homeostasis driven by pre-task activation from the first session (Tononi and Cirelli 2014), and the connection strength is now related to subsequent performance. This intriguing hypothesis fits with our data and the iOtA theory , but further evidence is certainly needed to confirm this.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Cross-modal transfer of statistical information benefits from sleep

Durrant

Cairney

Lewis

2016

Cortex

View full text Add to dashboard Cite

Extracting regularities from a sequence of events is essential for understanding our environment. However, there is no consensus regarding the extent to which such regularities can be generalised beyond the modality of learning. One reason for this could be the variation in consolidation intervals used in different paradigms, also including an opportunity to sleep. Using a novel statistical learning paradigm in which structured information is acquired in the auditory domain and tested in the visual domain over either 30min or 24hr consolidation intervals, we show that cross-modal transfer can occur, but this transfer is only seen in the 24hr group. Importantly, the extent of cross-modal transfer is predicted by the amount of SWS obtained. Additionally, cross-modal transfer is associated with the same pattern of decreasing MTL and increasing striatal involvement which has previously been observed to occur across 24 hours in unimodal statistical learning. We also observed enhanced functional connectivity after 24 hours in a network of areas which have been implicated in cross-modal integration including the precuneus and the middle occipital gyrus. Finally, functional connectivity between the striatum and the precuneus was also enhanced, and this strengthening was predicted by SWS. These results demonstrate that statistical learning can generalise to some extent beyond the modality of acquisition, and together with our previously published unimodal results, support the notion that statistical learning is both domain-general and domain-specific.

show abstract

Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration

Cited by 1,803 publications

References 245 publications

Sleep restriction can attenuate prioritization benefits on declarative memory consolidation

Sleep restriction can attenuate prioritization benefits on declarative memory consolidation

Sleep deficits but no metabolic deficits in premanifest Huntington's disease

Cross-modal transfer of statistical information benefits from sleep

Contact Info

Product

Resources

About