Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women.

Driver, Helen S.; Dijk, Derk‐Jan; Werth, Esther; Biedermann, K; Borbély, Alexander A.

doi:10.1210/jcem.81.2.8636295

Cited by 153 publications

(156 citation statements)

References 21 publications

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“…48.8 years old) with and without insomnia reports that both groups of women experience increased awakenings and arousal during sleep and decreased SWS during the luteal versus the follicular phase. Moreover, in both groups, the sleep spindles in the luteal phase compared with the the follicular phase exhibit marked increases in number, duration and higher EEG spectral frequency (14-17 Hz) [86], which is in agreement with earlier reports in younger women [87,88]. Nevertheless, earlier PSG studies report stability of sleep across the menstrual cycle [89,90].…”

Section: (C) Sex Steroids Influence Sleepsupporting

confidence: 91%

Sex differences in sleep: impact of biological sex and sex steroids

Mong

Cusmano

2016

Phil. Trans. R. Soc. B

408

300

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One contribution of 16 to a theme issue 'Multifaceted origins of sex differences in the brain'. Men and women sleep differently. While much is known about the mechanisms that drive sleep, the reason for these sex differences in sleep behaviour is unknown and understudied. Historically, women and female animals are underrepresented in studies of sleep and its disorders. Nevertheless, there is a growing recognition of sex disparities in sleep and rhythm disorders. Women typically report poorer quality and more disrupted sleep across various stages of life. Findings from clinical and basic research studies strongly implicate a role for sex steroids in sleep modulation. Understanding how neuroendocrine mediators and sex differences influence sleep is central to advancing our understanding of sleep-related disorders. The investigation into sex differences and sex steroid modulation of sleep is in its infancy. Identifying the mechanisms underlying sex and gender differences in sleep will provide valuable insights leading to tailored therapeutics that benefit each sex. The goal of this review is to discuss our current understanding of how biological sex and sex steroids influence sleep behaviour from both the clinical and pre-clinical perspective.

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Section: (C) Sex Steroids Influence Sleepsupporting

confidence: 91%

Sex differences in sleep: impact of biological sex and sex steroids

Mong

Cusmano

2016

Phil. Trans. R. Soc. B

408

300

View full text Add to dashboard Cite

show abstract

“…It is unclear whether these sex differences in spindle activity relate to meaningful functional differences or whether they are simply an artifact from differences in skull thickness that amplifies the detection of spindles in women (cite check Dijk et al, 1988). In addition, it has been shown that spindle activity increases during luteal phase compare to follicular phase (Baker at., 2007;Baker et al, 2012, Driver et al, 1996Ishizuka et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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Memory formation can be influenced by sleep and sex hormones in both men and women, and by the menstrual cycle in women. Though many studies have shown that sleep benefits the consolidation of memories, it is not clear whether this effect differs between men and women in general or according to menstrual phase in women. The present study investigated the effect of sex and menstrual cycle on memory consolidation of face-name associations (FNA) following a daytime nap. Recognition memory was tested using a face-name paired associates task with a polysomnographic nap between morning and evening testing. Seventeen healthy women (age: 20.75 (1.98) years) were studied at two time points of their menstrual cycles, defined from self-report and separated by 2 weeks (perimenses: -5 days to + 6 days from the start of menses, and non-perimenses: outside of the perimenses phase) and compared with eighteen healthy men (age: 22.01 (2.91) years). Regardless of menstrual phase, women had better pre-nap performance than men. Further, menstrual phase affected post-nap memory consolidation, with women showing greater forgetting in their perimenses phase compared with their nonperimenses phase, and men. Interestingly, post-nap performance correlated with electrophysiological events during sleep (slow oscillations, spindles, and temporal coupling between the two), however, these correlations differed according to menstrual phase and sex.Men's performance improvement was associated with the temporal coupling of spindles and slow oscillations (i.e., spindle/SO coincidence) as well as spindles. Women, however, showed an association with slow oscillations during non-perimenses, whereas when they were in their perimenses phase of their cycle, women appeared to show an association only with sleep spindle events for consolidation. These findings add to the growing literature demonstrating sex and menstrual phase effects on memory formation during sleep. THE EFFECT OF SEX AND MENSTRUAL CYCLE ON MEMORY 3

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“…These studies, however, did not take gender-differences into account. The reason for the gender-specific changes in the high-frequency spindles in the course of depression is not known, but it might be due to the influence of sex steroids as this frequency range is also mainly affected by the menstrual cycle (Driver et al, 1996) and by sex steroids like progesterone (Friess et al, 1997). As alterations in the concentration of sex steroids are observed during depression (Baischer et al, 1995;Toren et al, 1996), an interaction between endocrine chances and sleep-EEG changes in the course of depression seems likely.…”

Section: Discussionmentioning

confidence: 99%

State Markers of Depression in Sleep EEG: Dependency on Drug and Gender in Patients Treated with Tianeptine or Paroxetine

Murck

Nickel

Künzel

et al. 2003

Neuropsychopharmacol

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Tianeptine enhances while paroxetine inhibits serotonin reuptake into neurons; however, both show an antidepressive action. A subgroup of 38 depressed patients from a drug trial comparing the efficacy of tianeptine with that of paroxetine was studied with regard to their effects on sleep regulation, especially in relation to treatment response. We recorded sleep EEGs at day 7 and day 42 after the start of treatment with either compound, which allows measurement of changes due to the antidepressive medication in relation to the duration of treatment. Spectral analysis of the non-REM sleep EEG revealed a strong decline in the higher sigma frequency range (14-16 Hz) in male treatment responders independent of medication, whereas nonresponders did not show marked changes in this frequency range independent of gender. The patients receiving paroxetine showed less REM sleep and more intermittent wakefulness compared to the patients receiving tianeptine. REM density after 1 week of treatment was a predictor of treatment response in the whole sample. Psychopathological features with regard to the score in single items of the HAMD revealed predictive markers for response, some of which were opposite in the gender groups, especially those related to somatic anxiety. Changes in REM density were inversely correlated to the changes in HAMD in the paroxetine, but not the tianeptine, group. Our data suggest the importance of taking gender into account in the study of the biological effects of drugs. The study further points to the importance of the higher sigma frequency range in the sleep EEG of non-REM sleep and REM density as a marker of treatment response.

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Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women.

Cited by 153 publications

References 21 publications

Sex differences in sleep: impact of biological sex and sex steroids

Sex differences in sleep: impact of biological sex and sex steroids

The effect of sex and menstrual phase on memory formation during a nap

State Markers of Depression in Sleep EEG: Dependency on Drug and Gender in Patients Treated with Tianeptine or Paroxetine

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