Sleep apnea and diet-induced obesity—the female advantage on the spotlight

Badran, Mohammad; Joseph, Vincent

doi:10.1093/sleep/zsad174

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that an increase in BMI is associated with a variety of diseases. At a systemic level, higher BMI is linked to a greater risk of type 2 diabetes, cardiovascular diseases, and sleep apnea ( 7 , 8 ). Locally, when focusing on the eyes, higher BMI is also significantly associated with age-related cataracts, age-related macular degeneration, and diabetic retinopathy ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the causal relationship between body mass index and keratoconus: a Mendelian randomization study

Wang,

Liu,

et al. 2024

Front. Med.

View full text Add to dashboard Cite

BackgroundDespite reports suggesting a link between obesity and keratoconus, the causal relationship is not fully understood.MethodsWe used genome-wide association study (GWAS) data from public databases for a two-sample Mendelian randomization analysis to investigate the causal link between body mass index (BMI) and keratoconus. The primary method was inverse variance weighted (IVW), complemented by different analytical techniques and sensitivity analyses to ensure result robustness. A meta-analysis was also performed to bolster the findings’ reliability.ResultsOur study identified a significant causal relationship between BMI and keratoconus. Out of 20 Mendelian randomization (MR) analyses conducted, 9 showed heterogeneity or pleiotropy. Among the 11 analyses that met all three MR assumptions, 4 demonstrated a significant causal difference between BMI and keratoconus, while the remaining 7 showed a positive trend but were not statistically significant. Meta-analysis confirmed a significant causal relationship between BMI and keratoconus.ConclusionThere is a significant causal relationship between BMI and keratoconus, suggesting that obesity may be a risk factor for keratoconus.

show abstract