Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study

Association between sleep-disordered breathing, obstructive sleep apnea, and cancer incidence: a systematic review and meta-analysis

“…Estimates were reported as risk ratios (RRs) with 95% confidence intervals (CIs). Of the five included studies [16,17,[24][25][26], three studies [16,17,26] performed multivariate Cox proportional-hazards regression and reported adjusted hazard ratios of the association between SDB/OSA and incident cancer. On the other hand, the remaining two included studies [24,25] performed multivariate logistic regression analysis and reported adjusted odds ratios of the association between SDB/OSA and incident cancer.…”

Putative Links Between Sleep Apnea and Cancer

“…52 In another clinic-based prospective study in Taiwan, OSA cases (n 5 846) exhibited a 2.1-higher hazard of breast cancer incidence over 5 years compared with non-OSA control subjects (n 5 4,230). 53 Two other studies, however, found no associations between OSA and cancer incidence. 54,55 In a populationbased retrospective cohort (n 5 8,783) in Copenhagen, Denmark, history of snoring and daytime sleepiness were not associated with cancer incidence 54 ; inferences from this study are limited by the lack of objective measures of OSA.…”

“…Two studies from Taiwan used electronic health records to assess the association between OSA and incidence of site-specifi c cancers. 52,53 In one of these studies, based on . 90,000 claim records and a 10-year follow-up, an AHI Ն 5/h of total sleep time was associated with a statistically signifi cant, yet modest, increase in the risk of CNS cancers (HR 5 1.5).…”

Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer

“…Among 23,055 OSA patients, the risk of central nervous system (CNS) malignancy was 1.5 times that of age-and gender-matched non-apneic controls over a 2-year period, with the greatest risk seen in subjects with both OSA and insomnia (HR 2.20) (116). A five year follow up of 846 women with OSA found a two-fold risk of breast cancer when compared to age-matched controls in a cohort derived from a subset of the same database (117).…”