Sleep apnea in patients with chronic heart failure

Steiner, S; Schwartzkopff, B; Strauer, B. E.; Schultze‐Werninghaus, G.; Duchna, H.-W

doi:10.1055/s-2005-863079

Dtsch med Wochenschr

2005

DOI: 10.1055/s-2005-863079

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Sleep apnea in patients with chronic heart failure

S Steiner¹,

B Schwartzkopff²,

B. E. Strauer³

et al.

Abstract: Während der letzten 50 Jahre konnte die Prognose der Patienten mit Herzinsuffizienz sowohl durch neue medikamentöse Therapiekonzepte (17) als auch durch interventionelle und chirurgische Revaskularisationsverfahren bei koronarer Herzkrankheit (KHK) sowie in neuerer Zeit durch spezielle antibradykarde und antitachykarde Schrittmachersysteme gebessert werden. Dennoch ist die Letalität der Herzinsuffizienz hoch (25), so dass die Weiterentwicklung neuer Therapieoptionen wünschenswert ist.Bei der Herzinsuffizienz h… Show more

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Cited by 3 publications

References 7 publications

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CPAP-Therapie als additive/adjuvante Herzinsuffizienztherapie?

Schannwell

Strauer

2005

Internist

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Chronic heart failure with its age-dependent prevalence and incidence is one of the most frequent diseases. Due to high mortality and morbidity there is the necessity of early diagnosis and therapeutic measures being as causal as possible. The medical graded therapy is based on the combination of ACE-inhibitors/AT1-blockers, beta-blockers, diuretics and digitalis. Cardiac resynchronization therapy represents a novel option of treatment for only 25% of patients. Nevertheless the prognosis of patients with chronic heart failure with conventional medical therapy is remaining poor. Additional improvement in the treatment of patient with chronic heart failure remains a priority medical task. The results of this case report argues for CPAP as further adjunctive treatment option in patients with chronic heart failure.

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CPAP-Therapie als additive/adjuvante Herzinsuffizienztherapie?

Schannwell

Strauer

2005

Internist

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Einfluss der CPAP- (continuous positive airway pressure) Therapie auf die kardiale Funktion und Struktur nach 5 Jahren bei Patienten mit koprävalenter, behandelter arterieller Hypertonie und obstruktivem Schlafapnoe-Syndrom (OSAS)

Wehde¹,

Walther²,

Lindstaedt³

et al. 2012

Pneumologie

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Left Ventricular Response to Continuous Positive Airway Pressure: Role of Left Ventricular Geometry

Steiner

Schannwell²,

Strauer³

2008

Respiration

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Background: Continuous positive airway pressure (CPAP) may be a useful adjunct in patients with congestive heart failure. Objectives: To evaluate the relationship between left ventricular geometry and hemodynamic response to CPAP. Methods: Right heart catheter studies were performed in 26 patients before, during and after application of CPAP (8 cm H₂O) over 15 min. Response to therapy was defined as an increase in stroke volume using CPAP. Results: Cardiac output decreased from 6.9 ± 1.9 to 6.2 ± 1.4 liters/min (p = 0.01) with a slight increase after cessation of CPAP (not significant). There was no significant change in stroke volume (92 ± 34 vs. 90 ± 31 ml, p = 0.584) or pulmonary capillary wedge pressure (14.7 ± 7.0 vs. 14.2 ± 6.5 mm Hg, p = 0.26). There was a correlation between hemodynamic effects of CPAP therapy and left ventricular end-diastolic volume (r = 0.515, p = 0.01), mass-volume ratio (r = –0.41, p = 0.04) and pulmonary capillary wedge pressure (r = 0.654, p = 0.001) at baseline. Half the patients (n = 13) were categorized as responders with an average increase in stroke volume of 11.5 ± 2.1%. Responders showed significantly higher left ventricular end-diastolic volume, pulmonary capillary wedge pressure and lower mass-volume ratio. Conclusion: Patients with high pulmonary capillary wedge pressure, elevated end-diastolic volumes and a low left ventricular mass-volume ratio might profit from CPAP therapy.

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Sleep apnea in patients with chronic heart failure

Cited by 3 publications

References 7 publications

CPAP-Therapie als additive/adjuvante Herzinsuffizienztherapie?

CPAP-Therapie als additive/adjuvante Herzinsuffizienztherapie?

Einfluss der CPAP- (continuous positive airway pressure) Therapie auf die kardiale Funktion und Struktur nach 5 Jahren bei Patienten mit koprävalenter, behandelter arterieller Hypertonie und obstruktivem Schlafapnoe-Syndrom (OSAS)

Left Ventricular Response to Continuous Positive Airway Pressure: Role of Left Ventricular Geometry

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